High-affinity, blood-brain-barrier permeable, non-toxic, tertiary amide\xa0RAGE (Receptor for Advanced Glycation End products) receptor antagonist (K i = 25 nM). Blocks Aβ binding to the V domain of RAGE.
Storage Temp
Protected from light,Store at -20°C,Desiccated
Shipped In
Ice chest + Ice pads
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Shipped at 4°C. Store at -20°C long term. Store In the Dark. Store under desiccating conditions.
Associated Targets(Human)
AGERTchemAdvanced glycosylation end product-specific receptor (3 Activities)
1.Zeng F et al.. (2021) Receptor for advanced glycation end products up-regulation in cerebral endothelial cells mediates cerebrovascular-related amyloid ß accumulation after Porphyromonas gingivalis infection.. J Neurochem, 158 (3):(724-736). [PMID:32441775]
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A2211861