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FTase Inhibitor I - ≥98%, high purity , CAS No.149759-96-6
a potent, selective, peptidomimetic FTase inhibitor
Basic Description Synonyms B581 | B-581 | IDI1_033936 | BRD-K04877770-001-03-4 | SCHEMBL2723960 | STK368865 | HMS1361J08 | FTase Inhibitor I | KBio2_002754 | KBioGR_000186 | DTXSID30164381 | J-010695 | L-Methionine, N-(N-(2-((2-amino-3-mercaptopropyl)amino)-3-methylbutyl)-L-phenyla Specifications & Purity ≥98% Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Product Description FTase Inhibitor I is a potent, cell-permeable, selective, peptidomimetic inhibitor of Farnesyl Transferase (FTase). It is ~37-fold more active against Farnesyl Transferase (FTase) than against GGTase (geranylgeranyltransferase). Is also very resistant to proteolysis.
Product Properties pKa pKa: 3.04 (Predicted), pKa: 9.41 (Predicted)
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name (2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-amino-3-sulfanylpropyl]amino]-3-methylbutyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoic acid INCHI InChI=1S/C22H38N4O3S2/c1-15(2)20(24-12-17(23)14-30)13-25-19(11-16-7-5-4-6-8-16)21(27)26-18(22(28)29)9-10-31-3/h4-8,15,17-20,24-25,30H,9-14,23H2,1-3H3,(H,26,27)(H,28,29)/t17-,18+,19+,20-/m1/s1 InChi Key QISLMXIYRQCLIR-FUMNGEBKSA-N Canonical SMILES CC(C)C(CNC(CC1=CC=CC=C1)C(=O)NC(CCSC)C(=O)O)NCC(CS)N Isomeric SMILES CC(C)[C@@H](CN[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCSC)C(=O)O)NC[C@H](CS)N WGK Germany 3 PubChem CID 132887 Molecular Weight 470.69
Chemical and Physical Properties Solubility Soluble in DMSO (5 mg/ml), and water (1 mg/ml). Refractive Index n20D1.57 (Predicted) Boil Point(°C) 716.11° C at 760 mmHg (Predicted) Melt Point(°C) 334.02° C (Predicted)
Safety and Hazards(GHS) WGK Germany 3 RIDADR NONHforallmodesoftransport
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