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FTY720 (R)-Phosphate - ≥98%, high purity , CAS No.402616-23-3
an immunomodulator & inhibitor of lymphocyte emigration as well as a S1P agonist
Basic Description Synonyms Fingolimod phosphate | FTY720 phosphate | 402615-91-2 | 402616-23-3 | FTY720-phosphate | FTY720 (R)-Phosphate | rac FTY720 Phosphate | fingolimod-P | [2-amino-2-(hydroxymethyl)-4-(4-octylphenyl)butyl] dihydrogen phosphate | CHEMBL114606 | RAC FTY 720 PHOSPHATE | CHEBI:73420 | 2- Specifications & Purity ≥98% Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Product Description FTY720 (R)-Phosphate, FTY720 is a novel immune modulator that inhibits lymphocyte emigration from lymphoid organs, which prolongs allograft transplant survival in numerous models. Sphingosine kinases phosphorylate FTYS20 in vivo so that FTYS20 acts as a potent agonist at four of the five sphingosine-1-phosphate (S1P) receptors . FTY720 (R)-phosphate is one stereoisomer of FTY720-phosphate, but it is evidently not formed in vivo. FTY720 (S)-phosphate exhibits K|i|values of 2.1, 5.9, 23, and 2.2 nM for S1P1,3,4,5, respectively, while the R isomer binds with 5-130-fold lower affinity.
Product Properties pKa pKₐ: 1.73 (Predicted), pKₐ: 10.04 (Predicted)
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name [2-amino-2-(hydroxymethyl)-4-(4-octylphenyl)butyl] dihydrogen phosphate INCHI InChI=1S/C19H34NO5P/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-25-26(22,23)24/h9-12,21H,2-8,13-16,20H2,1H3,(H2,22,23,24) InChi Key LRFKWQGGENFBFO-UHFFFAOYSA-N Canonical SMILES CCCCCCCCC1=CC=C(C=C1)CCC(CO)(COP(=O)(O)O)N Isomeric SMILES CCCCCCCCC1=CC=C(C=C1)CCC(CO)(COP(=O)(O)O)N Alternate CAS 402616-23-3 PubChem CID 9908268 MeSH Entry Terms 2-amino-2-(2-(4-octylphenyl)ethyl)-1,3-propanediol monodihydrogen phosphate ester;FTY 720P;FTY-720P;FTY720 phosphate;FTY720-P;FTY720P Molecular Weight 387.5
Chemical and Physical Properties Solubility Soluble in chloroform (~0.5 mg/ml). Refractive Index n20D1.54 (Predicted) Boil Point(°C) ~584.2° C at 760 mmHg (Predicted) Melt Point(°C) 90.27° C (Predicted)
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