Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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F125644-25mg | 25mg | In stock | $124.90 | |
F125644-100mg | 100mg | In stock | $362.90 | |
F125644-250mg | 250mg | In stock | $725.90 | |
F125644-1g | 1g | In stock | $2,322.90 |
Estrogen receptor antagonist
Synonyms | Faslodex(ICI 182,780) | FULVESTRANT [MI] | ICI 182,789 | Q27274130 | CAS-129453-61-8 | NCGC00164789-02 | NCGC00164789-04 | BI167222 | AS-13024 | CS-1267 | FULVESTRANT (EP MONOGRAPH) | FULVESTRANT [EMA EPAR] | ICI-182780 | P19940 | SCHEMBL8209 | (7R,8R,9S, |
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Specifications & Purity | Moligand™, ≥99% |
Biochemical and Physiological Mechanisms | ICI 182,780 is a high affinity estrogen receptor antagonist (IC50 = 0.29 nM), devoid of any partial agonism in vitro and ICI 182,780 is also a high affinity agonist at the membrane estrogen receptor, GPR30.Estrogen receptor antagonist with no partial agon |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | AGONIST, ANTAGONIST |
Mechanism of action | Estrogen receptor antagonist |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
ALogP | 9.2 |
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Pubchem Sid | 488187370 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488187370 |
IUPAC Name | (7R,8R,9S,13S,14S,17S)-13-methyl-7-[9-(4,4,5,5,5-pentafluoropentylsulfinyl)nonyl]-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol |
INCHI | InChI=1S/C32H47F5O3S/c1-30-17-15-26-25-12-11-24(38)21-23(25)20-22(29(26)27(30)13-14-28(30)39)10-7-5-3-2-4-6-8-18-41(40)19-9-16-31(33,34)32(35,36)37/h11-12,21-22,26-29,38-39H,2-10,13-20H2,1H3/t22-,26-,27+,28+,29-,30+,41?/m1/s1 |
InChi Key | VWUXBMIQPBEWFH-WCCTWKNTSA-N |
Canonical SMILES | CC12CCC3C(C1CCC2O)C(CC4=C3C=CC(=C4)O)CCCCCCCCCS(=O)CCCC(C(F)(F)F)(F)F |
Isomeric SMILES | C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)[C@@H](CC4=C3C=CC(=C4)O)CCCCCCCCCS(=O)CCCC(C(F)(F)F)(F)F |
WGK Germany | 3 |
RTECS | KG7623000 |
PubChem CID | 104741 |
Molecular Weight | 606.77 |
PubChem CID | 104741 |
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DrugBank Ligand | DB00947 |
CAS Registry No. | 129453-61-8 |
Wikipedia | Fulvestrant |
ChEMBL Ligand | CHEMBL1358 |
BindingDB Ligand | 50169743 |
ChEBI | CHEBI:31638 |
NURSA Ligand | 10.1621/WZYNUBUNGT |
DrugCentral Ligand | 1255 |
GPCRdb Ligand | fulvestrant |
PubChem SID | 488187370 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
G2221124 | Certificate of Analysis | May 22, 2024 | F125644 |
L2305224 | Certificate of Analysis | Nov 24, 2023 | F125644 |
L2305220 | Certificate of Analysis | Nov 24, 2023 | F125644 |
G2315646 | Certificate of Analysis | Jul 07, 2023 | F125644 |
G2315635 | Certificate of Analysis | Jul 07, 2023 | F125644 |
G2315633 | Certificate of Analysis | Jul 07, 2023 | F125644 |
G2315632 | Certificate of Analysis | Jul 07, 2023 | F125644 |
G2315629 | Certificate of Analysis | Jul 07, 2023 | F125644 |
G1714045 | Certificate of Analysis | Feb 07, 2023 | F125644 |
B23091184 | Certificate of Analysis | Jan 04, 2023 | F125644 |
B2309978 | Certificate of Analysis | Jan 04, 2023 | F125644 |
B2309974 | Certificate of Analysis | Jan 04, 2023 | F125644 |
B2309959 | Certificate of Analysis | Jan 04, 2023 | F125644 |
B2309833 | Certificate of Analysis | Jan 04, 2023 | F125644 |
B23091015 | Certificate of Analysis | Jan 04, 2023 | F125644 |
G2221213 | Certificate of Analysis | Jun 02, 2022 | F125644 |
G2221212 | Certificate of Analysis | Jun 02, 2022 | F125644 |
Solubility | ≥30.35 mg/mL in DMSO; insoluble in H2O; ≥58.9 mg/mL in EtOH |
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Melt Point(°C) | 104 - 112 °C |
Pictogram(s) | GHS08, GHS09, GHS07 |
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Signal | Danger |
Hazard Statements | H319:Causes serious eye irritation H373:Causes damage to organs through prolonged or repeated exposure H413:May cause long lasting harmful effects to aquatic life H302:Harmful if swallowed H400:Very toxic to aquatic life H410:Very toxic to aquatic life with long lasting effects H360:May damage fertility or the unborn child H362:May cause harm to breast-fed children |
Precautionary Statements | P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P270:Do not eat, drink or smoke when using this product. P391:Collect spillage. P330:Rinse mouth. P263:Avoid contact during pregnancy/while nursing. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P337+P317:If eye irritation persists: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
RTECS | KG7623000 |
Starting at $249.90
Starting at $121.90
1. Hong Liu, Yang Huang, Jing Yang, Xuejiao Xu, Qiaomei Dai, Yuwei Zhang, Li Zhao, Mengdi Zhang, Jing Zhang, Tonghui Liu, Lili Zhong. (2023) Involvement of estrogen receptor activation in kaempferol-3-O-glucoside's protection against aging-related cognition impairment and microglial inflammation. EXPERIMENTAL CELL RESEARCH, (113849). [PMID:37926343] |
2. Xiu Yanghui, Su Yu, Gao Lihua, Yuan Hui, Xu Sennan, Liu Ying, Qiu Yan, Liu Zhen, Li Yuhang. (2023) Corylin accelerated wound healing through SIRT1 and PI3K/AKT signaling: a candidate remedy for chronic non-healing wounds. Frontiers in Pharmacology, 14 [PMID:37266148] |
1. Schennink A et al.. (2013) A novel first exon directs hormone-sensitive transcription of the pig prolactin receptor.. J Mol Endocrinol, 51 (1-13). [PMID:23576686] |
2. Bao C et al.. (2022) A novel oncogenic enhancer of estrogen receptor-positive breast cancer.. Mol Ther Nucleic Acids, 29 (836-851). [PMID:36159594] |
3. Xu X et al.. (2019) 17ß-Estradiol nongenomically induces vascular endothelial H2S release by promoting phosphorylation of cystathionine ?-lyase.. J Biol Chem, 294 (43): (15577-15592). [PMID:31439665] |
4. Xiao L et al.. (2014) Induction of the CLOCK gene by E2-ERa signaling promotes the proliferation of breast cancer cells.. PLoS One, 9 (5): (e95878). [PMID:24789043] |
5. Keil KP et al.. (2017) In vivo and in vitro sex differences in the dendritic morphology of developing murine hippocampal and cortical neurons.. Sci Rep, 7 (8486). [PMID:28814778] |
6. Xiao L et al.. (2019) Profile of melatonin and its receptors and synthesizing enzymes in cumulus-oocyte complexes of the developing sheep antral follicle-a potential estradiol-mediated mechanism.. Reprod Biol Endocrinol, 17 (1). [PMID:30606208] |
7. Traboulsi T et al.. (2019) Role of SUMOylation in differential ERa transcriptional repression by tamoxifen and fulvestrant in breast cancer cells.. Oncogene, 38 (7): (1019-1037). [PMID:30190545] |
8. Wang Z et al.. (2018) The in vitro estrogenic activity of the crude drugs found in Japanese herbal medicines prescribed for menopausal syndrome was enhanced by combining them.. BMC Complement Altern Med, 18 (107). [PMID:29566679] |
9. Hong Liu, Yang Huang, Jing Yang, Xuejiao Xu, Qiaomei Dai, Yuwei Zhang, Li Zhao, Mengdi Zhang, Jing Zhang, Tonghui Liu, Lili Zhong. (2023) Involvement of estrogen receptor activation in kaempferol-3-O-glucoside's protection against aging-related cognition impairment and microglial inflammation. EXPERIMENTAL CELL RESEARCH, (113849). [PMID:37926343] |
10. Xiu Yanghui, Su Yu, Gao Lihua, Yuan Hui, Xu Sennan, Liu Ying, Qiu Yan, Liu Zhen, Li Yuhang. (2023) Corylin accelerated wound healing through SIRT1 and PI3K/AKT signaling: a candidate remedy for chronic non-healing wounds. Frontiers in Pharmacology, 14 [PMID:37266148] |