Determine the necessary mass, volume, or concentration for preparing a solution.
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Basic Description
| Synonyms | fumaric acid | 110-17-8 | trans-Butenedioic acid | Allomaleic acid | fumarate | Lichenic acid | Boletic acid | 2-Butenedioic acid | (2E)-but-2-enedioic acid | Tumaric acid | trans-1,2-Ethylenedicarboxylic acid | Allomalenic acid | But-2-enedioic acid | trans-2-Butenedioic acid | (E) |
|---|---|
| Specifications & Purity | ≥99.5% |
| Shipped In | Normal |
| Product Description | Fumaric acid can be prepared by fermentation by employing Rhizopus species.Recently, industrial-scale synthesis of fumaric acid from renewable feedstocks and lignocellulosic biomass has been proposed Fumaric acid has been used as a standard for the quantitative determination of phenolic compounds in nettle samples by HPLC. Fumaric acid may be used in the preparation of L-Lysine-fumaric acid crystals.It may also be employed for the industrial manufacture of synthetic resins and eco-friendly/biodegradable polymers |
Associated Targets(Human)
EGFR Tclin Epidermal growth factor receptor erbB1 (33727 Activities)
CA2 Tclin Carbonic anhydrase II (17698 Activities)
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ESR1 Tclin Estrogen receptor alpha (17718 Activities)
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NR3C1 Tclin Glucocorticoid receptor (14987 Activities)
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PGR Tclin Progesterone receptor (8562 Activities)
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ADRB2 Tclin Beta-2 adrenergic receptor (11824 Activities)
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CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)
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ADRB1 Tclin Beta-1 adrenergic receptor (6630 Activities)
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HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)
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ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)
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AR Tclin Androgen Receptor (11781 Activities)
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CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)
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DRD2 Tclin Dopamine D2 receptor (23596 Activities)
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GABRA1 Tclin GABA receptor alpha-1 subunit (399 Activities)
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TSHR Tclin Thyroid stimulating hormone receptor (29986 Activities)
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MAOA Tclin Monoamine oxidase A (11911 Activities)
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CNR1 Tclin Cannabinoid CB1 receptor (20913 Activities)
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DRD1 Tclin Dopamine D1 receptor (9720 Activities)
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ACHE Tclin Acetylcholinesterase (18204 Activities)
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PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)
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SLC6A2 Tclin Norepinephrine transporter (10102 Activities)
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HTR2A Tclin Serotonin 2a (5-HT2a) receptor (14758 Activities)
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HTR2C Tclin Serotonin 2c (5-HT2c) receptor (11471 Activities)
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ADORA1 Tclin Adenosine A1 receptor (17603 Activities)
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AGTR1 Tclin Type-1 angiotensin II receptor (5176 Activities)
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SLC6A4 Tclin Serotonin transporter (12625 Activities)
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ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)
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PTGS2 Tclin Cyclooxygenase-2 (13999 Activities)
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HRH1 Tclin Histamine H1 receptor (7573 Activities)
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OPRM1 Tclin Mu opioid receptor (19785 Activities)
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DRD3 Tclin Dopamine D3 receptor (14368 Activities)
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PPARG Tclin Peroxisome proliferator-activated receptor gamma (15191 Activities)
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AVPR1A Tclin Vasopressin V1a receptor (5412 Activities)
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OPRD1 Tclin Delta opioid receptor (15096 Activities)
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HTR3A Tclin Serotonin 3a (5-HT3a) receptor (3366 Activities)
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SLC6A3 Tclin Dopamine transporter (10535 Activities)
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PDE3A Tclin Phosphodiesterase 3A (3309 Activities)
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SLC29A1 Tclin Equilibrative nucleoside transporter 1 (1711 Activities)
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ERBB2 Tclin Receptor protein-tyrosine kinase erbB-2 (7851 Activities)
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ADRA2B Tclin Alpha-2b adrenergic receptor (4412 Activities)
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ADRA2C Tclin Alpha-2c adrenergic receptor (4876 Activities)
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CHRM3 Tclin Muscarinic acetylcholine receptor M3 (7750 Activities)
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HTR2B Tclin Serotonin 2b (5-HT2b) receptor (10323 Activities)
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EDNRA Tclin Endothelin receptor ET-A (5008 Activities)
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ADORA2A Tclin Adenosine A2a receptor (16305 Activities)
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ADORA3 Tchem Adenosine A3 receptor (15931 Activities)
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CA1 Tclin Carbonic anhydrase I (13240 Activities)
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HRH3 Tclin Histamine H3 receptor (10389 Activities)
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CHRNA4 Tclin Neuronal acetylcholine receptor protein alpha-4 subunit (1265 Activities)
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EGLN2 Tclin Hypoxia-inducible factor prolyl hydroxylase 1 (404 Activities)
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Associated Targets(non-human)
Papain (844 Activities)
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Cckar Cholecystokinin A receptor (90 Activities)
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Pde4d Phosphodiesterase 4D (4 Activities)
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Hcar2 Hydroxycarboxylic acid receptor 2 (55 Activities)
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BALB/3T3 (534 Activities)
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Slc22a20 Solute carrier family 22 member 20 (86 Activities)
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Slc22a6 Solute carrier family 22 member 6 (141 Activities)
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GAPDH Glyceraldehyde-3-phosphate dehydrogenase (59 Activities)
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Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)
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A085R Prolyl 4-hydroxylase (72 Activities)
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Names and Identifiers
| IUPAC Name | (E)-but-2-enedioic acid |
|---|---|
| INCHI | InChI=1S/C4H4O4/c5-3(6)1-2-4(7)8/h1-2H,(H,5,6)(H,7,8)/b2-1+ |
| InChi Key | VZCYOOQTPOCHFL-OWOJBTEDSA-N |
| Canonical SMILES | C(=CC(=O)O)C(=O)O |
| Isomeric SMILES | C(=C/C(=O)O)\C(=O)O |
| WGK Germany | 1 |
| RTECS | LS9625000 |
| PubChem CID | 444972 |
| Molecular Weight | 116.07 |
| Beilstein | 605763 |
Certificates
Certificate of Analysis(COA)
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 E2414176 | Certificate of Analysis | May 24, 2024 | F110742 |
| F2205125 | Certificate of Analysis | Mar 18, 2024 | F110742 |
| F2205133 | Certificate of Analysis | Mar 18, 2024 | F110742 |
| L2116352 | Certificate of Analysis | Sep 20, 2023 | F110742 |
| L2116355 | Certificate of Analysis | Sep 20, 2023 | F110742 |
| D2122250 | Certificate of Analysis | Jan 17, 2023 | F110742 |
| D2122251 | Certificate of Analysis | Jan 17, 2023 | F110742 |
| A2310136 | Certificate of Analysis | Dec 13, 2022 | F110742 |
| A2310137 | Certificate of Analysis | Dec 13, 2022 | F110742 |
| A2310138 | Certificate of Analysis | Dec 13, 2022 | F110742 |
| A2310174 | Certificate of Analysis | Dec 13, 2022 | F110742 |
| H2014118 | Certificate of Analysis | Jun 14, 2022 | F110742 |
| F2205131 | Certificate of Analysis | Mar 15, 2022 | F110742 |
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Chemical and Physical Properties
| Solubility | Soluble in water, ethanol and concentrated sulfuric acid. Slightly soluble in ethyl ether and acetone. Insoluble in chloroform, olive oil, carbon tetrachloride, xylene, molten camphor, liquid ammonia and benzene；Solubility in Methanol almost transparency |
|---|---|
| Sensitivity | Moisture sensitive. |
| Flash Point(°F) | 523°F |
| Flash Point(°C) | 273 °C |
| Melt Point(°C) | 287°C |
Safety and Hazards(GHS)
| Pictogram(s) | GHS07 |
|---|---|
| Signal | Warning |
| Hazard Statements | H319:Causes serious eye irritation |
| Precautionary Statements | P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. |
| WGK Germany | 1 |
| RTECS | LS9625000 |
| Merck Index | 4287 |
Related Documents
FAQs and Articles
FAQ
Metabolic signaling pathway
Categories: Technical articles
Citations of This Product
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| 2. Yuan Guo, Yuping Duan, Xiaoji Liu, Hao Zhang, Tingkang Yuan, Ningxuan Wen, Chengwei Li, Huifang Pan, Zeng Fan, Lujun Pan. (2023) Boosting Conductive Loss and Magnetic Coupling Based on “Size Modulation Engineering” toward Lower-Frequency Microwave Absorption. Small, (31): (2308809). [PMID:38041445] |
| 3. Hang Yin, Xiao Bai, Ziyin Yang. (2023) Activating Ni nanoparticles into Ni single atoms by N doping for high-performance electrochemical sensing of glucose. CHEMICAL ENGINEERING JOURNAL, 478 (147510). [PMID:11564868] |
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| 6. Jiadong Zhu, Jianbo Hu, Hao Xiao, Lifeng Yang, Mingshan Yang, Shucheng Wang, Jianjun Zhang, Huabin Xing. (2024) Aluminum-based metal organic frameworks for greenhouse gases CF4 and C2F6 capture with excellent capacity and selectivity. SEPARATION AND PURIFICATION TECHNOLOGY, 331 (125614). [PMID:12861482] |
| 7. Xia-Lin Dai, Bo-Wen Pang, Wen-Ting Lv, Jian-Feng Zhen, Lu Gao, Cai-Wen Li, Jing Xiong, Tong-Bu Lu, Jia-Mei Chen. (2023) Improving the physicochemical and pharmacokinetic properties of olaparib through cocrystallization strategy. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 647 (26): (123497). [PMID:37827390] |
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| 39. Nan Li, Changping Jian, Yaping Song, Li Wang, Ata Ur Rehman, Yanghe Fu, Fumin Zhang, De-Li Chen, Weidong Zhu. (2023) Scalable synthesis of MIL-88A(Fe) for efficient aerobic oxidation of cyclohexene to 2-cyclohexene-1-ol. Molecular Catalysis, 535 (112899). [PMID:] |
| 40. Meng Dong, Ran Xin, Zhi-Yuan Li, Yu-Lian Li, Xu-Hui Huang, Xiu-Ping Dong, Bei-Wei Zhu, Lei Qin. (2023) Simultaneously quantification of organic acids metabolites by HPLC mass spectrometry to reveal the postharvest quality change in cherry tomato. JOURNAL OF FOOD COMPOSITION AND ANALYSIS, 117 (105105). [PMID:] |
| 41. Zhiyong Li, Kairui Shi, Liyong Zhai, Zhenzhen Wang, Huiyong Wang, Yang Zhao, Jianji Wang. (2023) Constructing multiple sites of metal-organic frameworks for efficient adsorption and selective separation of CO2. SEPARATION AND PURIFICATION TECHNOLOGY, 307 (122725). [PMID:] |
| 42. Xue-Wei Wei, Cong Chen, Tian-Yu Wu, Li-Hai Cai, Hai-Mu Ye. (2022) Promoting Co-Crystallization in Poly(butylene succinate) and Poly(butylene fumarate) Blends via End-Group Functionalization. MOLECULES, 27 (20): (7086). [PMID:36296685] |
| 43. Huihua Luo, Lianqing Yu, Kehui Xue, Haifeng Zhu, Yaping Zhang. (2022) Ultrathin ZIS nanosheets encapsulated in metal–organic-framework-derived CNCo-Fe3O4 as an efficient functional photocatalyst for hydrogen evolution. Journal of Materials Chemistry A, 10 (42): (22453-22467). [PMID:] |
| 44. Xi Bao, Shiyao Zhang, Xueting Zhang, Yongli Jiang, Zhijia Liu, Xiaosong Hu, Junjie Yi. (2022) Effects of pasteurization technologies and storage conditions on the flavor changes in acidified chili pepper. Current Research in Food Science, 5 (1295). [PMID:36065197] |
| 45. Panpan Liu, Jiafei Lyu, Peng Bai. (2022) Base-functionalized metal−organic frameworks for highly efficient removal of organic acid pollutants from water. MICROPOROUS AND MESOPOROUS MATERIALS, 343 (112164). [PMID:] |
| 46. Qiuju Fu, Dandan Liu, Weijing Niu, Shuo Zhang, Ruihua Chen, Yujia Wang, Pengze Zhao, Huimin Jiang, Yanchao Zhao, Lingzhi Yang, Liting Yan, Haiyan Wang, Xuebo Zhao. (2022) Defect-engineered MOF-808 with highly exposed Zr sites as highly efficient catalysts for catalytic transfer hydrogenation of furfural. FUEL, 327 (125085). [PMID:] |
| 47. Tao Huang, Rongrong Zheng, Haiyang Chang, Di Ma, Haijun Niu. (2022) Green fruit organic primary battery: Positive citric acid, negative sodium tert-pentoxide. JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 920 (116582). [PMID:] |
| 48. Qiuwan Shen, Zicheng Shao, Zhongwen Cai, Min Yan, Guogang Yang, Shian Li. (2022) Enhancement of hydrogen production performance of novel perovskite LaNi0.4Al0.6O3-δ supported on MOF A520-derived λ-Al2O3. INTERNATIONAL JOURNAL OF ENERGY RESEARCH, 46 (11): (15709-15721). [PMID:] |
| 49. Xueqi Shi, Meng Yang, Aqiang Chu, Fengyi Zhang, Jing Fang, Ning Xu, Yanjun Jiang, Hao Li. (2022) Separation of α-ketoglutaric acid by salting-out extraction coupled with solar-driven distillation. AICHE JOURNAL, 68 (10): (e17814). [PMID:] |
| 50. Shaoheng Yang, Heng Fang, Hai Li, Fangning Shen, Xudong Chen, Yang Hu, Zhuohong Yang. (2022) Synthesis of tung oil-based vinyl ester resin and its application for anti-corrosion coatings. PROGRESS IN ORGANIC COATINGS, 170 (106967). [PMID:] |
| 51. Meng-Yao Wu, Fan-Zhi Bu, Yu Yu, Yue-Ming Yu, Zhi-Yong Wu, Cui-Wei Yan, Yan-Tuan Li. (2022) The comparison researches of cis/trans-butenedioic acids in regulating solid crystalline forms and improving pharmaceutical properties of antifungal drug econazole. JOURNAL OF MOLECULAR STRUCTURE, 1263 (133183). [PMID:] |
| 52. Wei Xue-Wei, Zhao Xin-Xin, Li Yi, Meng Xiao-Yu, Zhou Qiong, Ye Hai-Mu. (2022) Distinctive Polymorphism-like Isodimorphism in Poly(propylene succinate-ran-propylene fumarate). CHINESE JOURNAL OF POLYMER SCIENCE, 40 (6): (602-610). [PMID:] |
| 53. Chunyuan Wu, Haikuan Dong, Gaoshen Su, Huan Yang, Xiaorong Yu. (2022) The effect of the structure of functional monomers on the resistance of copolymers to Fe2+ and S2-. JOURNAL OF PETROLEUM SCIENCE AND ENGINEERING, 212 (110309). [PMID:] |
| 54. Zhiyuan Zhao, Jinna Zhang, Jie Yao, Shijie You. (2022) Electrochemical removal of 4-chlorophenol in water using a porous Magnéli-phase (Ti4O7) electrode. ENVIRONMENTAL RESEARCH, 210 (113004). [PMID:35218709] |
| 55. Wenbo Xie, Hao Li, Yao Sun, Wen Li, Fengmei Yi, Lu Xia, Fuhou Lei. (2022) Separating and purifying of Panax notoginseng saponins using a rosin-based polymer-bonded with silica as a high-performance liquid chromatography stationary phase. MICROCHEMICAL JOURNAL, 176 (107234). [PMID:] |
| 56. Li Lu, Qianqian Xu, Yeke Chen, Yujie Zhou, Tingshun Jiang, Qian Zhao. (2022) Preparation of metal sulfide electrode materials derived based on metal organic framework and application of supercapacitors. Journal of Energy Storage, 49 (104073). [PMID:] |
| 57. Zhenghui Huang, Peng Hu, Jia Liu, Fang Shen, Youquan Zhang, Kungang Chai, Yunpan Ying, Chengjun Kang, Zhaoqiang Zhang, Hongbing Ji. (2022) Enhancing CH4/N2 separation performance within aluminum-based Metal-Organic Frameworks: Influence of the pore structure and linker polarity. SEPARATION AND PURIFICATION TECHNOLOGY, 286 (120446). [PMID:] |
| 58. Huilan Sun, Ya Su, Fei Yuan, Zhaojin Li, Wen Li, Haitao Sun, Yazhao Li, Yan Zhang, Bo Wang. (2022) Fe2P nanoparticles-doped carbon nanofibers with enhanced electrons transfer capability as a self-supporting anode for potassium-ion battery. ELECTROCHIMICA ACTA, 404 (139759). [PMID:] |
| 59. Hang Liu, Hua Yin, Minghan Zhu, Zhi Dang. (2022) Degradation of organophosphorus flame retardants in heterogeneous photo-Fenton system driven by Fe(III)-based metal organic framework: Intermediates and their potential interference on bacterial metabolism. CHEMOSPHERE, 291 (133072). [PMID:34838833] |
| 60. Yi He, Jiayu Guo, Xiazhen Yang, Bing Guo, Hangyan Shen. (2021) Highly sensitive humidity-driven actuators based on metal–organic frameworks incorporating thermoplastic polyurethane with gradient polymer distribution. RSC Advances, 11 (60): (37744-37751). [PMID:35498101] |
| 61. Xiaogu Huang, Yabin Ma, Haoran Lai, Qi Jia, Liyan Zhu, Jun Liu, Bin Quan. (2022) Conductive substrates-based component tailoring via thermal conversion of metal organic framework for enhanced microwave absorption performances. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 608 (1323). [PMID:34742057] |
| 62. Xue-Wei Wei, Lu-Lu Yang, Yi Li, Xiaoyu Meng, Li-Hai Cai, Qiong Zhou, Hai-Mu Ye. (2021) Asymmetrical formation of isomorphism in the crystalline/crystalline blend of poly(butylene succinate) and poly(butylene fumarate). POLYMER, 235 (124282). [PMID:] |
| 63. Wenbo Liu, Jiabin Zhou, Dan Liu, Su Liu, Xianjie Liu. (2022) MIL-88/Go derived Fe2O3/rGO as a photo-Fenton catalyst: Free radical generation by multipath electron transfer. MATERIALS LETTERS, 307 (131076). [PMID:] |
| 64. Jiao Danhua, Cai Xiaodong, Song Qun, Zhou Ruiqun, Peng Xiao, Bao Dongmei. (2021) Biodegradable aliphatic poly(carbonate-co-ester)s containing biobased unsaturated double bonds: synthesis and structure-property relationships. POLYMER JOURNAL, 54 (1): (47-55). [PMID:] |
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| 51. Meng-Yao Wu, Fan-Zhi Bu, Yu Yu, Yue-Ming Yu, Zhi-Yong Wu, Cui-Wei Yan, Yan-Tuan Li. (2022) The comparison researches of cis/trans-butenedioic acids in regulating solid crystalline forms and improving pharmaceutical properties of antifungal drug econazole. JOURNAL OF MOLECULAR STRUCTURE, 1263 (133183). [PMID:] |
| 52. Wei Xue-Wei, Zhao Xin-Xin, Li Yi, Meng Xiao-Yu, Zhou Qiong, Ye Hai-Mu. (2022) Distinctive Polymorphism-like Isodimorphism in Poly(propylene succinate-ran-propylene fumarate). CHINESE JOURNAL OF POLYMER SCIENCE, 40 (6): (602-610). [PMID:] |
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| 59. Hang Liu, Hua Yin, Minghan Zhu, Zhi Dang. (2022) Degradation of organophosphorus flame retardants in heterogeneous photo-Fenton system driven by Fe(III)-based metal organic framework: Intermediates and their potential interference on bacterial metabolism. CHEMOSPHERE, 291 (133072). [PMID:34838833] |
| 60. Yi He, Jiayu Guo, Xiazhen Yang, Bing Guo, Hangyan Shen. (2021) Highly sensitive humidity-driven actuators based on metal–organic frameworks incorporating thermoplastic polyurethane with gradient polymer distribution. RSC Advances, 11 (60): (37744-37751). [PMID:35498101] |
| 61. Xiaogu Huang, Yabin Ma, Haoran Lai, Qi Jia, Liyan Zhu, Jun Liu, Bin Quan. (2022) Conductive substrates-based component tailoring via thermal conversion of metal organic framework for enhanced microwave absorption performances. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 608 (1323). [PMID:34742057] |
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