furin inhibitor peptide, CAS No.rp174048, Inhibitor of furin; paired basic amino acid cleaving enzyme;Inhibitor of proprotein convertase subtilisin/kexin type 4;Inhibitor of proprotein convertase subtilisin/kexin type 5;Inhibitor of proprotein convertase subtilisin/kexin type 6;Inhibitor of propr

Features and benefits
    Item Number
    rp174048
    Grouped product items
    SKUSizeAvailabilityPrice Qty
    rp174048-500μg
    500μg
    Available within 8-12 weeks(?)
    Production requires sourcing of materials. We appreciate your patience and understanding.
    $1,334.90
    rp174048-1mg
    1mg
    Available within 8-12 weeks(?)
    Production requires sourcing of materials. We appreciate your patience and understanding.
    $2,334.90

    Basic Description

    Product Namefurin inhibitor peptide, CAS No.rp174048
    GradeMoligand™
    Specifications & PurityMoligand™
    Action TypeINHIBITOR
    Mechanism of actionInhibitor of furin; paired basic amino acid cleaving enzyme;Inhibitor of proprotein convertase subtilisin/kexin type 4;Inhibitor of proprotein convertase subtilisin/kexin type 5;Inhibitor of proprotein convertase subtilisin/kexin type 6;Inhibitor of propr

    Associated Targets(Human)

    FURIN Tchem Furin (0 Activities)
    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
    PCSK5 Tchem Proprotein convertase subtilisin/kexin type 5 (0 Activities)
    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
    PCSK6 Tchem Proprotein convertase subtilisin/kexin type 6 (0 Activities)
    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
    PCSK4 Tbio Proprotein convertase subtilisin/kexin type 4 (0 Activities)
    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
    PCSK7 Tchem Proprotein convertase subtilisin/kexin type 7 (0 Activities)
    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
    PCSK4 Tbio Subtilisin/kexin type 4 (6 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
    PCSK7 Tchem Subtilisin/kexin type 7 (37 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
    PCSK5 Tchem Subtilisin/kexin type 5 (16 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
    FURIN Tchem Furin (909 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Associated Targets(non-human)

    Mus musculus (284745 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
    RAW264.7 (28094 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
    Pcsk6 Proprotein convertase subtilisin/kexin type 6 (7 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Product Specifications

    CASrp174048

    Certificates

    Certificate of Analysis(COA)

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    Genetic information

    Reference
    • 1. Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration., The Journal of biological chemistry, Steegborn, C C and 7 more authors.
    • 2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences., Proceedings of the National Academy of Sciences of the United States of America, Strausberg, Robert L RL and 83 more authors.
    • 3. Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH)., Human genetics, Wang, Jian J and Hegele, Robert A RA.
    • 4. Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase., Biochemical and biophysical research communications, Lu, Y Y, O'Dowd, B F BF, Orrego, H H and Israel, Y Y.
    • 5. Single nucleotide polymorphism in CTH associated with variation in plasma homocysteine concentration., Clinical genetics, Wang, J J, Huff, A M AM, Spence, J D JD and Hegele, R A RA.
    • 6. Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1., The Journal of biological chemistry, Yang, Guangdong G, Cao, Kun K, Wu, Lingyun L and Wang, Rui R.
    • 7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)., Genome research, Gerhard, Daniela S DS and 115 more authors.
    • 8. Towards a proteome-scale map of the human protein-protein interaction network., Nature, Rual, Jean-François JF and 37 more authors.
    • 9. The DNA sequence and biological annotation of human chromosome 1., Nature, Gregory, S G SG and 178 more authors.
    • 10. Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer., International journal of cancer, Moore, Lee E LE and 14 more authors. more

    Related Documents

    References

    1. Shiryaev SA, Remacle AG, Ratnikov BI, Nelson NA, Savinov AY, Wei G, Bottini M, Rega MF, Parent A, Desjardins R et al..  (2007)  Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens..  J Biol Chem,  282  (29): (20847-53).  [PMID:17537721]

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