Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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F129560-1g | 1g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $64.90 | |
F129560-5g | 5g | In stock | $195.90 | |
F129560-25g | 25g | In stock | $882.90 | |
F129560-100g | 100g | In stock | $3,175.90 |
Inhibitor of the Na + /2Cl - /K + cotransporter. Also GABA A antagonist.
Synonyms | Diuzol | Furomen | Lasix | Radisemide | Salix | Urosemide | Furosan | Furose | Aldalix | Endural | Diural | Diurin | Lowpston | Seguril | Edemid | Uresix | Aluzine | Desdemin | Furodrix | Moilarorin | Urian | Frusemide | Frusenex | Furosemix | Novosemide |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Furosemide is a loop diuretic inhibitor of NKCC (Na+/2Cl-/K+) cotransporter. Furosemide acts as a non-competitive antagonist at GABAA receptors with ~ 100-fold greater selectivity for α6-containing receptors than α1-containing receptors.Inhibitor of the N |
Storage Temp | Protected from light,Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | AGONIST, ALLOSTERIC MODULATOR, INHIBITOR |
Mechanism of action | Sodium-(potassium)-chloride cotransporter 2 inhibitor |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Furosemide is a diuretic drug, which finds a variety of therapeutic applications such as hepatic cirrhosis, cardiac insufficiency and arterial hypertension. Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Furosemide is classified under the group of loop diuretics. It is used for the prevention of hypertension linked to renal and cardiac insufficiency. |
ALogP | 2 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 4-chloro-2-(furan-2-ylmethylamino)-5-sulfamoylbenzoic acid |
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INCHI | InChI=1S/C12H11ClN2O5S/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h1-5,15H,6H2,(H,16,17)(H2,14,18,19) |
InChi Key | ZZUFCTLCJUWOSV-UHFFFAOYSA-N |
Canonical SMILES | C1=COC(=C1)CNC2=CC(=C(C=C2C(=O)O)S(=O)(=O)N)Cl |
Isomeric SMILES | C1=COC(=C1)CNC2=CC(=C(C=C2C(=O)O)S(=O)(=O)N)Cl |
WGK Germany | 3 |
RTECS | CB2625000 |
PubChem CID | 3440 |
Molecular Weight | 330.74 |
DrugBank Ligand | DB00695 |
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Wikipedia | Furosemide |
ChEBI | CHEBI:47426 |
CAS Registry No. | 54-31-9 |
PubChem CID | 3440 |
ChEMBL Ligand | CHEMBL35 |
RCSB PDB Ligand | FUN |
PEP | furosemide |
DrugCentral Ligand | 1258 |
GPCRdb Ligand | furosemide |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
H2205062 | Certificate of Analysis | May 13, 2024 | F129560 |
H2205063 | Certificate of Analysis | May 13, 2024 | F129560 |
H2205064 | Certificate of Analysis | May 13, 2024 | F129560 |
K2421337 | Certificate of Analysis | Apr 03, 2024 | F129560 |
K2421424 | Certificate of Analysis | Apr 03, 2024 | F129560 |
D2422230 | Certificate of Analysis | Mar 25, 2024 | F129560 |
D2422231 | Certificate of Analysis | Mar 25, 2024 | F129560 |
D2422232 | Certificate of Analysis | Mar 25, 2024 | F129560 |
D2422233 | Certificate of Analysis | Mar 25, 2024 | F129560 |
E2129157 | Certificate of Analysis | Mar 13, 2023 | F129560 |
E2129159 | Certificate of Analysis | Mar 13, 2023 | F129560 |
B1525035 | Certificate of Analysis | Aug 12, 2022 | F129560 |
A2418068 | Certificate of Analysis | Jul 21, 2022 | F129560 |
H2205065 | Certificate of Analysis | Jul 21, 2022 | F129560 |
J2307036 | Certificate of Analysis | Jul 21, 2022 | F129560 |
E2129158 | Certificate of Analysis | Jun 03, 2021 | F129560 |
Solubility | Soluble in DMSO (66 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), methanol (50 mg/ml), and DMF. |
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Sensitivity | Light sensitive |
Pictogram(s) | GHS08 |
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Signal | Danger |
Hazard Statements | H360:May damage fertility or the unborn child |
Precautionary Statements | P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P203:Obtain, read and follow all safety instructions before use. P318:if exposed or concerned, get medical advice. |
WGK Germany | 3 |
RTECS | CB2625000 |
Starting at $15.90
Starting at $9.90
1. Guang-Rong Wu, Jia-Kun Xu, Li-Juan Sun, Ying-Fu Li, Shu-Qin Gao, Ying-Wu Lin. (2023) Application of engineered heme enzymes based on myoglobin with high peroxidase activity for efficient degradation of various emerging pollutants. Journal of Environmental Chemical Engineering, 11 (17): (111471). [PMID:9751059] [10.1016/j.jece.2023.111471] |
2. Haoyu Long, Yanhao Jiang, Yanjuan Liu, Yuefei Zhang, Wei Chen, Sheng Tang. (2023) Chromatographic separation performance of silica microspheres surface-modified with triazine-containing imine-linked covalent organic frameworks. TALANTA, 260 (124589). [PMID:37126925] [10.1016/j.talanta.2023.124589] |
3. Xueyan Gou, Fenglin Ran, Jinru Yang, Yanrong Ma, Xin’an Wu. (2022) Construction and Evaluation of a Novel Organic Anion Transporter 1/3 CRISPR/Cas9 Double-Knockout Rat Model. Pharmaceutics, 14 (11): (2307). [PMID:36365126] [10.3390/pharmaceutics14112307] |
4. Yuhua Zhang, Qiaojun Fang, Hongfeng Wang, Jieyu Qi, Shan Sun, Menghui Liao, Yunhao Wu, Yangnan Hu, Pei Jiang, Cheng Cheng, Xiaoyun Qian, Mingliang Tang, Wei Cao, Shang Xiang, Chen Zhang, Jianming Yang, Xia Gao, Zheng Ying, Renjie Chai. (2023) Increased mitophagy protects cochlear hair cells from aminoglycoside-induced damage. Autophagy, 19 (1): (75-91). [PMID:35471096] [10.1080/15548627.2022.2062872] |
5. Zhu Zaisheng, Xu Lingling, Liu Yujie, Wang Xiufang, Tian Yong. (2022) The synthesis of novel nanoparticles: transition from hollow to groove via self-template sacrifice strategy. JOURNAL OF POROUS MATERIALS, 29 (4): (1049-1059). [PMID:] [10.1007/s10934-022-01229-x] |
1. Guang-Rong Wu, Jia-Kun Xu, Li-Juan Sun, Ying-Fu Li, Shu-Qin Gao, Ying-Wu Lin. (2023) Application of engineered heme enzymes based on myoglobin with high peroxidase activity for efficient degradation of various emerging pollutants. Journal of Environmental Chemical Engineering, 11 (17): (111471). [PMID:9751059] [10.1016/j.jece.2023.111471] |
2. Haoyu Long, Yanhao Jiang, Yanjuan Liu, Yuefei Zhang, Wei Chen, Sheng Tang. (2023) Chromatographic separation performance of silica microspheres surface-modified with triazine-containing imine-linked covalent organic frameworks. TALANTA, 260 (124589). [PMID:37126925] [10.1016/j.talanta.2023.124589] |
3. Xueyan Gou, Fenglin Ran, Jinru Yang, Yanrong Ma, Xin’an Wu. (2022) Construction and Evaluation of a Novel Organic Anion Transporter 1/3 CRISPR/Cas9 Double-Knockout Rat Model. Pharmaceutics, 14 (11): (2307). [PMID:36365126] [10.3390/pharmaceutics14112307] |
4. Yuhua Zhang, Qiaojun Fang, Hongfeng Wang, Jieyu Qi, Shan Sun, Menghui Liao, Yunhao Wu, Yangnan Hu, Pei Jiang, Cheng Cheng, Xiaoyun Qian, Mingliang Tang, Wei Cao, Shang Xiang, Chen Zhang, Jianming Yang, Xia Gao, Zheng Ying, Renjie Chai. (2023) Increased mitophagy protects cochlear hair cells from aminoglycoside-induced damage. Autophagy, 19 (1): (75-91). [PMID:35471096] [10.1080/15548627.2022.2062872] |
5. Zhu Zaisheng, Xu Lingling, Liu Yujie, Wang Xiufang, Tian Yong. (2022) The synthesis of novel nanoparticles: transition from hollow to groove via self-template sacrifice strategy. JOURNAL OF POROUS MATERIALS, 29 (4): (1049-1059). [PMID:] [10.1007/s10934-022-01229-x] |