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FX 1 - ≥98%(HPLC), high purity , CAS No.1426138-42-2
Bcl-6 inhibitor; 10-fold more potent than endogenous Bcl-6 corepressors
Basic Description
| Synonyms | (5Z)-5-(5-Chloro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)-4-oxo-2-thioxo-3-thiazolidinepropanoic acid;FX1；(Z)-3-(5-(5-Chloro-2-oxoindolin-3-ylidene)-4-oxo-2-thioxothiazolidin-3-yl)propanoic acid, (5Z)-5-(5-Chloro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)-4-oxo-2 |
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| Specifications & Purity | ≥98%(HPLC) |
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| Biochemical and Physiological Mechanisms | Bcl-6 inhibitor (Kd= 3 μM); exhibits 10-fold greater potency than endogenous Bcl-6 corepressors. Disrupts formation of Bcl-6 repression complex. Induces regression of established tumors in mice bearing DLBCL xenograft. |
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| Storage Temp | Store at -20°C |
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| Shipped In | Ice chest + Ice pads |
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Associated Targets(Human)
Associated Targets(non-human)
Names and Identifiers
| IUPAC Name | 3-[5-(5-chloro-2-oxoindol-3-yl)-4-hydroxy-2-sulfanylidene-1,3-thiazol-3-yl]propanoic acid |
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| INCHI | InChI=1S/C14H9ClN2O4S2/c15-6-1-2-8-7(5-6)10(12(20)16-8)11-13(21)17(14(22)23-11)4-3-9(18)19/h1-2,5,21H,3-4H2,(H,18,19) |
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| InChi Key | JYBGCTWNOMSQJY-UHFFFAOYSA-N |
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| Canonical SMILES | C1=CC2=NC(=O)C(=C2C=C1Cl)C3=C(N(C(=S)S3)CCC(=O)O)O |
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| Isomeric SMILES | C1=CC2=NC(=O)C(=C2C=C1Cl)C3=C(N(C(=S)S3)CCC(=O)O)O |
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| PubChem CID | 135886621 |
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| Molecular Weight | 368.82 |
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Chemical and Physical Properties
| Solubility | Solvent:DMSO, Max Conc. mg/mL: 36.88, Max Conc. mM: 100 |
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Safety and Hazards(GHS)
| Pictogram(s) | GHS07 |
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| Signal | Warning |
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| Hazard Statements | H302:Harmful if swallowed |
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| Precautionary Statements | P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. |
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| RIDADR | NONHforallmodesoftransport |
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