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FzM1.8 - 98%, high purity , CAS No.2204290-85-5, Allosteric modulator of FZD 4
Frizzled 4 allosteric agonist; exhibits biased siginaling; preserves stemness
Basic Description Specifications & Purity Moligand™, ≥98% Biochemical and Physiological Mechanisms FzM1.8 comes from FzM1 and is an allosteric agonist of FZD4 with a pEC50 of 6.4. FzM1.8 promotes TCF/LEF transcriptional activity in the absence of any WNT ligand, binds to FZD4, and activates WNT/ β- The catenin pathway. FzM1.8 binds to stable FZD4, incr Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type ALLOSTERIC MODULATOR Mechanism of action Allosteric modulator of FZD 4
Associated Targets(Human) Names and Identifiers IUPAC Name 3-hydroxy-5-(naphthalen-2-ylcarbamoylamino)benzoic acid INCHI InChI=1S/C18H14N2O4/c21-16-9-13(17(22)23)8-15(10-16)20-18(24)19-14-6-5-11-3-1-2-4-12(11)7-14/h1-10,21H,(H,22,23)(H2,19,20,24) InChi Key XGNNCRZDDAJBFU-UHFFFAOYSA-N Canonical SMILES C1=CC=C2C=C(C=CC2=C1)NC(=O)NC3=CC(=CC(=C3)C(=O)O)O PubChem CID 137553171 Molecular Weight 322.32
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 32.23, Max Conc. mM: 100
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F2302862