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FzM1 , CAS No.1680196-54-6, Allosteric modulator of FZD 4

Item Number

F610431

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SKU	Size	Availability	Price	Qty
F610431-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
F610431-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,001.90

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Basic Description

FZD4 Tchem Frizzled-4 (1 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IUPAC Name	1-(3-hydroxy-5-thiophen-2-ylphenyl)-3-naphthalen-2-ylurea
INCHI	InChI=1S/C21H16N2O2S/c24-19-12-16(20-6-3-9-26-20)11-18(13-19)23-21(25)22-17-8-7-14-4-1-2-5-15(14)10-17/h1-13,24H,(H2,22,23,25)
InChi Key	OBTSACXGWYGCPK-UHFFFAOYSA-N
Canonical SMILES	C1=CC=C2C=C(C=CC2=C1)NC(=O)NC3=CC(=CC(=C3)C4=CC=CS4)O
Isomeric SMILES	C1=CC=C2C=C(C=CC2=C1)NC(=O)NC3=CC(=CC(=C3)C4=CC=CS4)O
PubChem CID	90478321
Molecular Weight	360.43

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RIDADR	NONHforallmodesoftransport

1. Generoso SF, Giustiniano M, La Regina G, Bottone S, Passacantilli S, Di Maro S, Cassese H, Bruno A, Mallardo M, Dentice M et al.. (2015) Pharmacological folding chaperones act as allosteric ligands of Frizzled4.. Nat Chem Biol, 11 (4): (280-6). [PMID:25751279] [10.1021/op500134e]
2. Riccio G, Bottone S, La Regina G, Badolati N, Passacantilli S, Rossi GB, Accardo A, Dentice M, Silvestri R, Novellino E et al.. (2018) A Negative Allosteric Modulator of WNT Receptor Frizzled 4 Switches into an Allosteric Agonist.. Biochemistry, 57 (5): (839-851). [PMID:29293331] [10.1021/op500134e]

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