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G-1 - ≥98%(HPLC), high purity , CAS No.881639-98-1
Potent and selective GPER agonist
Basic Description Synonyms 1-[4-(6-Bromo-2H-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]ethan-1-one | 1-[(3aR,4S,9bS)-4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]-ethanone | CHEBI:123624 | GPR30 inhibitor G1 | HMS Specifications & Purity ≥98%(HPLC) Biochemical and Physiological Mechanisms Potent and selective GPER agonist (Ki= 11 nM, EC50= 2 nM); displays no activity at ERαand ERβat concentrations up to 10μM. Increases cytosolic Ca2+and inhibits migration of SKBr3 cells and MCF-7 cells in response to chemoattractants (IC50values are 0.7 an Storage Temp Store at -20°C,Argon charged Shipped In Ice chest + Ice pads Product Description Product description：
G-1 is a nonsteroidal, high-affinity and selective agonist of GPR30 with a Ki of 11 nM.
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 1-[4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]ethanone INCHI InChI=1S/C21H18BrNO3/c1-11(24)12-5-6-18-15(7-12)13-3-2-4-14(13)21(23-18)16-8-19-20(9-17(16)22)26-10-25-19/h2-3,5-9,13-14,21,23H,4,10H2,1H3 InChi Key VHSVKVWHYFBIFJ-UHFFFAOYSA-N Canonical SMILES CC(=O)C1=CC2=C(C=C1)NC(C3C2C=CC3)C4=CC5=C(C=C4Br)OCO5 Isomeric SMILES CC(=O)C1=CC2=C(C=C1)NC(C3C2C=CC3)C4=CC5=C(C=C4Br)OCO5 PubChem CID 3136849 Molecular Weight 412.28
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 41.23, Max Conc. mM: 100
Safety and Hazards(GHS) Pictogram(s) GHS09 , GHS07 Signal Warning Hazard Statements H302: Harmful if swallowed
H400: Very toxic to aquatic life
Precautionary Statements P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P391: Collect spillage.
P330: Rinse mouth.
P301+P317: IF SWALLOWED: Get medical help.
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