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G-15 - ≥99%(HPLC), high purity , CAS No.1161002-05-6, Antagonist of GPER

Moligand™

≥99%(HPLC)

CAS#: 1161002-05-6
Formula: C₁₉H₁₆BrNO₂
Molecular Weight: 370.24
PubChem CID: 7433743

Item Number

G286562

Grouped product items
SKU	Size	Availability	Price
G286562-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$92.90
G286562-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$151.90
G286562-50mg	50mg	In stock	$467.90
G286562-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$804.90
G286562-250mg	250mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,811.90

High affinity and selective GPER antagonist

View related series

Estrogen Receptor/ERR GPER Antagonist Vitamin D Related/Nuclear Receptor

Basic Description

Specifications & Purity	Moligand™, ≥99%(HPLC)
Biochemical and Physiological Mechanisms	High affinity and selective GPER receptor antagonist (Ki= 20 nM) that displays no affinity for ERαand ERβat concentrations up to 10μM. Inhibits agonist-induced calcium mobilizationin vitro(EC50of ~185 nM) and antagonizes the antidepressive and renoprotect
Storage Temp	Protected from light,Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of GPER

Associated Targets(Human)

GPER1 Tchem G-protein coupled estrogen receptor 1 (3 Activities)

Discover Target: GPER1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ESR1 Tclin Estrogen receptor alpha (17718 Activities)

Discover Target: ESR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ESR2 Tclin Estrogen receptor beta (9272 Activities)

Discover Target: ESR2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MCF7 (126967 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MDA-MB-231 (73002 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	(3aS,4R,9bR)-4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline
INCHI	InChI=1S/C19H16BrNO2/c20-15-9-18-17(22-10-23-18)8-14(15)19-13-6-3-5-11(13)12-4-1-2-7-16(12)21-19/h1-5,7-9,11,13,19,21H,6,10H2/t11-,13-,19+/m0/s1
InChi Key	YOLTZIVRJAPVPH-MJLGCCKJSA-N
Canonical SMILES	C1C=CC2C1C(NC3=CC=CC=C23)C4=CC5=C(C=C4Br)OCO5
Isomeric SMILES	C1C=C[C@@H]2[C@H]1[C@@H](NC3=CC=CC=C23)C4=CC5=C(C=C4Br)OCO5
PubChem CID	7433743
Molecular Weight	370.24

Certificates

Certificate of Analysis(COA)

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5 results found

Lot Number	Certificate Type	Date	Item
J2115164	Certificate of Analysis	Jul 15, 2024	G286562
J2115202	Certificate of Analysis	Jul 15, 2024	G286562
J2115206	Certificate of Analysis	Jul 15, 2024	G286562
J2115245	Certificate of Analysis	Jul 15, 2024	G286562
L2322030	Certificate of Analysis	Sep 01, 2021	G286562

Solubility

Solvent:DMSO, Max Conc. mg/mL: 18.51, Max Conc. mM: 50

Sensitivity

light sensitive

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G-15 - ≥99%(HPLC), high purity , CAS No.1161002-05-6, Antagonist of GPER

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Related Documents

Solution Calculators

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Dilution Calculator

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