Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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G288842-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $23.90 | |
G288842-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $85.90 | |
G288842-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $129.90 | |
G288842-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $283.90 | |
G288842-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $482.90 | |
G288842-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $729.90 |
High affinity group I PAK inhibitor
Specifications & Purity | ≥98%(HPLC) |
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Biochemical and Physiological Mechanisms | High affinity group 1 PAK (pan-PAK1, 2 and 3) inhibitor (Ki= 3.7 nM; pMEK IC50= 69 nM). Of 235 kinases tested, other than PAK1, eight (PAK2, PAK3, KHS1, Lck, MST3, MST4, SIK2, and YSK1) were inhibited >70%. Exhibits low hERG channel activity (<50% inhibit |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
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IUPAC Name | 8-[(5-amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methylpyridin-2-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one |
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INCHI | InChI=1S/C25H25ClN6O3/c1-14-4-3-5-21(30-14)15-6-7-18(20(26)9-15)19-8-16-10-29-25(28-2)31-23(16)32(24(19)33)11-22-34-12-17(27)13-35-22/h3-10,17,22H,11-13,27H2,1-2H3,(H,28,29,31) |
InChi Key | ZBCMHWUFWQFPLV-UHFFFAOYSA-N |
Canonical SMILES | CC1=NC(=CC=C1)C2=CC(=C(C=C2)C3=CC4=CN=C(N=C4N(C3=O)CC5OCC(CO5)N)NC)Cl |
Isomeric SMILES | CC1=NC(=CC=C1)C2=CC(=C(C=C2)C3=CC4=CN=C(N=C4N(C3=O)CC5OCC(CO5)N)NC)Cl |
PubChem CID | 91664373 |
Molecular Weight | 492.96 |
Enter Lot Number to search for COA:
Solubility | Solvent:1eq. HCl, Max Conc. mg/mL: 49.3, Max Conc. mM: 100; Solvent:DMSO, Max Conc. mg/mL: 9.86, Max Conc. mM: 20 with gentle warming |
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Sensitivity | Moisture sensitive |