G140 - 98%, high purity , CAS No.2369751-07-3

Item Number

G647730

Grouped product items
SKU	Size	Availability	Price
G647730-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$90.90
G647730-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$270.90
G647730-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$420.90
G647730-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$840.90
G647730-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,350.90

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Basic Description

Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	G140 is a potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS) , with IC 50 s of 14.0u2009nM and 442u2009nM for h-cGAS and m-cGAS, respectively. G140 has anti-inflammatory activity.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	G140 is a potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS) , with IC 50 s of 14.0 nM and 442 nM for h-cGAS and m-cGAS, respectively. G140 has anti-inflammatory activity In Vitro G140 (0.1-100 μM; 4 h) inhibits h-cGAS in a dose-dependent manner with IC 50 s of 1.70 and 0.86?μM in human THP1 and primary macrophages, respectively. ?\nG140 (0.1-100 μM; 24 h) inhibits cells viability with a LD 50 of >100 μM in THP1 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 14.0 nM (h-cGAS), 442 nM (m-cGAS)

Associated Targets(Human)

THP-1 (11052 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CGAS Tchem Cyclic GMP-AMP synthase (693 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	1-[6,7-dichloro-9-(1-methylpyrazol-3-yl)-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl]-2-hydroxyethanone
INCHI	InChI=1S/C17H16Cl2N4O2/c1-22-4-2-13(21-22)9-6-11(18)16(19)17-15(9)10-7-23(14(25)8-24)5-3-12(10)20-17/h2,4,6,20,24H,3,5,7-8H2,1H3
InChi Key	NVPFAXHXXODQRO-UHFFFAOYSA-N
Canonical SMILES	CN1C=CC(=N1)C2=CC(=C(C3=C2C4=C(N3)CCN(C4)C(=O)CO)Cl)Cl
Isomeric SMILES	CN1C=CC(=N1)C2=CC(=C(C3=C2C4=C(N3)CCN(C4)C(=O)CO)Cl)Cl
PubChem CID	139388865
Molecular Weight	379.24

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Basic Description