G150 - 10mM in DMSO, high purity , CAS No.2369751-30-2

Item Number

G422778

Grouped product items
SKU	Size	Availability	Price	Qty
G422778-1ml	1ml	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$241.90

cGAS Inhibitors

Basic Description

Specifications & Purity	10mM in DMSO
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Product Description	Information G150 G150 is a potent and highly selective human cyclic GMP-AMP synthase (cGAS) inhibitor with IC50 of 10.2 nM. Targets h-cGAS (Cell-free assay) 10.2 nM In vitro The most potent h-cGAS-specific derivative with 2-amino pyridine (G150) shows inhibitory activity in THP1 cells and primary human macrophages while a complete absence of off-target effect on a diverse range of sensors. G150 also shows no substantial cellular toxicity. Cell Research(from reference) Cell lines：THP1 cells, primary macrophage cells Concentrations：10 μM and 5 μM Incubation Time：1 h

ALogP

2.353

HBD Count

Rotatable Bond

Associated Targets(Human)

CGAS Tchem Cyclic GMP-AMP synthase (1 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

THP-1 (11052 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CGAS Tchem Cyclic GMP-AMP synthase (693 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	1-[9-(6-aminopyridin-3-yl)-6,7-dichloro-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl]-2-hydroxyethanone
INCHI	InChI=1S/C18H16Cl2N4O2/c19-12-5-10(9-1-2-14(21)22-6-9)16-11-7-24(15(26)8-25)4-3-13(11)23-18(16)17(12)20/h1-2,5-6,23,25H,3-4,7-8H2,(H2,21,22)
InChi Key	VVUOUIPXYFIWLE-UHFFFAOYSA-N
Canonical SMILES	C1CN(CC2=C1NC3=C2C(=CC(=C3Cl)Cl)C4=CN=C(C=C4)N)C(=O)CO
Isomeric SMILES	C1CN(CC2=C1NC3=C2C(=CC(=C3Cl)Cl)C4=CN=C(C=C4)N)C(=O)CO
PubChem CID	138393372
Molecular Weight	391.25

DMSO(mg / mL) Max Solubility

DMSO(mM) Max Solubility

199.361022364217

Water(mg / mL) Max Solubility

＜1

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Basic Description