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G1T38 - 2mM in DMSO, high purity , CAS No.1628256-23-4, Inhibitor of cyclin dependent kinase 4;Inhibitor of cyclin dependent kinase 6

Item Number
G421989
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SKUSizeAvailabilityPrice Qty
G421989-1ml
1ml
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$241.90

CDK9 Selective Inhibitors

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Compound libraries (12338)

Basic Description

SynonymsLerociclib | 1628256-23-4 | G1T38 | G1T38 free base | G1T-38 | Lerociclib [USAN] | WBH8AY6ENB | Lerociclib (USAN) | 4-[[5-(4-propan-2-ylpiperazin-1-yl)pyridin-2-yl]amino]spiro[1,3,5,11-tetrazatricyclo[7.4.0.02,7]trideca-2,4,6,8-tetraene-13,1'-cyclohexane]-10-one | 2'-((5-(
Specifications & PurityMoligand™, 2mM in DMSO
Biochemical and Physiological MechanismsG1T38 (Lerociclib) is a novel, potent, selective, and orally bioavailable CDK4/6 inhibitor with IC50 values of 0.001 μM, 0.002 μM and 0.028 μM for CDK4, CDK6 and CDK9 respectively.
Storage TempStore at -80°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of cyclin dependent kinase 4;Inhibitor of cyclin dependent kinase 6
Product Description

Information

G1T38 (Lerociclib) is a novel, potent, selective, and orally bioavailableCDK4/6inhibitor with IC50 values of 0.001 μM, 0.002 μM and 0.028 μM for CDK4, CDK6 and CDK9 respectively.

Targets

CDK4 (Cell-free assay); CDK6 (Cell-free assay); CDK9 (Cell-free assay) 1 nM; 2 nM; 28 nM

In vitro

G1T38 is highly potent and selective for CDK4/cyclin D1 and CDK6/cyclin D3 over CDK1, CDK2, CDK5 and CDK7 and their respective binding partners. G1T38 decreases RB1 (RB) phosphorylation, causes a precise G1 arrest, and inhibits cell proliferation in a variety of CDK4/6-dependent tumorigenic cell lines including breast, melanoma, leukemia, and lymphoma cells with EC50 concentrations as low as 23 nM.

In vivo

G1T38 treatment leads to equivalent or improved tumor efficacy compared to the first-in-class CDK4/6 inhibitor, palbociclib, in an ER+ breast cancer xenograft model. Furthermore, G1T38 accumulates in mouse xenograft tumors but not plasma, resulting in less inhibition of mouse myeloid progenitors than after palbociclib treatment. In larger mammals, this difference in pharmacokinetics allows for 28 day continuous dosing of G1T38 in beagle dogs without producing severe neutropenia.

Cell Research(from reference)

Cell lines:WM2664 cells 

Concentrations:300 nM 

Incubation Time:1, 4, 8, 16, and 24 hours 

AI Insight

Product Properties

ALogP4.087
HBD Count2
Rotatable Bond4

Mechanisms of Action

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Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 4-[[5-(4-propan-2-ylpiperazin-1-yl)pyridin-2-yl]amino]spiro[1,3,5,11-tetrazatricyclo[7.4.0.02,7]trideca-2,4,6,8-tetraene-13,1'-cyclohexane]-10-one
INCHI InChI=1S/C26H34N8O/c1-18(2)32-10-12-33(13-11-32)20-6-7-22(27-16-20)30-25-28-15-19-14-21-24(35)29-17-26(8-4-3-5-9-26)34(21)23(19)31-25/h6-7,14-16,18H,3-5,8-13,17H2,1-2H3,(H,29,35)(H,27,28,30,31)
InChi Key YPJRHEKCFKOVRT-UHFFFAOYSA-N
Canonical SMILES CC(C)N1CCN(CC1)C2=CN=C(C=C2)NC3=NC=C4C=C5C(=O)NCC6(N5C4=N3)CCCCC6
Isomeric SMILES CC(C)N1CCN(CC1)C2=CN=C(C=C2)NC3=NC=C4C=C5C(=O)NCC6(N5C4=N3)CCCCC6
PubChem CID 86269224
Molecular Weight 474.6

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Chemical and Physical Properties

DMSO(mg / mL) Max Solubility2
DMSO(mM) Max Solubility4.21407501053519
Water(mg / mL) Max Solubility<1
Molecular Weight474.600 g/mol
XLogP33.400
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Exact Mass474.286 Da
Monoisotopic Mass474.286 Da
Topological Polar Surface Area91.200 Ų
Heavy Atom Count35
Formal Charge0
Complexity750.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1

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