Basic Description

Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	G6PDi-1 is an effective inhibitor of glucose-6-phosphate dehydrogenase (G6PD). G6PDi-1 depletes NADPH and decreases inflammatory cytokine production.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	Information G6PDi-1 G6PDi-1 is an effective inhibitor of glucose-6-phosphate dehydrogenase (G6PD) . G6PDi-1 depletes NADPH and decreases inflammatory cytokine production. Targets G6PD ; NADPH In vitro G6PDi-1 effectively inhibits G6PD. Across a range of cultured cells, G6PDi-1 depletes NADPH most strongly in lymphocytes. In T cells but not macrophages, G6PDi-1 markedly decreases inflammatory cytokine production. In neutrophils, it suppresses respiratory burst. Cell Research(from reference) Cell lines：HepG2 cells, HCT116 cells, T cells Concentrations：25 μM, 50 μM, 75 μM, 100 μM Incubation Time：2 h, 4 h, 6 h

Associated Targets(Human)

G6PD Tchem Glucose-6-phosphate 1-dehydrogenase (778 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

IUPAC Name	4-[(5-oxo-6,7,8,9-tetrahydrocyclohepta[d]pyrimidin-2-yl)amino]thiophene-2-carbonitrile
INCHI	InChI=1S/C14H12N4OS/c15-6-10-5-9(8-20-10)17-14-16-7-11-12(18-14)3-1-2-4-13(11)19/h5,7-8H,1-4H2,(H,16,17,18)
InChi Key	USWCHVCZOGGQQA-UHFFFAOYSA-N
Canonical SMILES	C1CCC(=O)C2=CN=C(N=C2C1)NC3=CSC(=C3)C#N
Isomeric SMILES	C1CCC(=O)C2=CN=C(N=C2C1)NC3=CSC(=C3)C#N
PubChem CID	145998284
Molecular Weight	284.34

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3 results found

Lot Number	Certificate Type	Date	Item
G2229306	Certificate of Analysis	Jun 06, 2022	G414430
G2229307	Certificate of Analysis	Jun 06, 2022	G414430
G2229325	Certificate of Analysis	Jun 06, 2022	G414430

Solubility	Solubility (25°C) In vitro DMSO: 57 mg/mL (200.46 mM); Water: Insoluble; Ethanol: Insoluble;

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

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SKU	Size	Availability	Price
G414430-5mg	5mg	In stock	$98.90
G414430-25mg	25mg	In stock	$345.90
G414430-100mg	100mg	In stock	$890.90