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Gabapentin - 98%, high purity , Voltage-gated calcium channel modulator, CAS No.60142-96-3, Voltage-gated calcium channel modulator

  • Moligand™
  • ≥98%
Item Number
G122413
Grouped product items
SKUSizeAvailabilityPrice Qty
G122413-5g
5g
In stock
$57.90
G122413-25g
25g
In stock
$175.90
G122413-100g
100g
In stock
$632.90
G122413-500g
500g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$2,847.90

α2δ Ligand

View related series
Kv7.3 Activator Kv7.5 Activator

Basic Description

Synonymsgabapentin|60142-96-3|Neurontin|Gabapentine|1-(Aminomethyl)cyclohexaneacetic acid|Aclonium|Gabapetin|Gabapentinum|2-[1-(aminomethyl)cyclohexyl]acetic acid|Gabapentino|Fanatrex|Gralise|Serada|Cyclohexaneacetic acid, 1-(aminomethyl)-|gabapentina|Vultin|Goe-
Specifications & Purity98%
Shipped InNormal
GradeMoligand™
Action TypeACTIVATOR, MODULATOR
Mechanism of actionVoltage-gated calcium channel modulator

Product Properties

ALogP-1.1

Associated Targets

KCNQ5 Tclin Potassium voltage-gated channel subfamily KQT member 5 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KCNQ3 Tclin Potassium voltage-gated channel subfamily KQT member 3 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 2-[1-(aminomethyl)cyclohexyl]acetic acid
INCHI InChI=1S/C9H17NO2/c10-7-9(6-8(11)12)4-2-1-3-5-9/h1-7,10H2,(H,11,12)
InChi Key UGJMXCAKCUNAIE-UHFFFAOYSA-N
Canonical SMILES C1CCC(CC1)(CC(=O)O)CN
Isomeric SMILES C1CCC(CC1)(CC(=O)O)CN
WGK Germany 3
RTECS GU6496000
PubChem CID 3446
Molecular Weight 171.24
Beilstein 2359739
Reaxy-Rn 2359739

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

13 results found

Lot NumberCertificate TypeDateItem
K2030189Certificate of AnalysisSep 10, 2024 G122413
K2030188Certificate of AnalysisSep 10, 2024 G122413
K2030187Certificate of AnalysisSep 10, 2024 G122413
A2408301Certificate of AnalysisNov 22, 2023 G122413
A2408302Certificate of AnalysisNov 22, 2023 G122413
A2408303Certificate of AnalysisNov 22, 2023 G122413
B2215034Certificate of AnalysisDec 08, 2021 G122413
B2215055Certificate of AnalysisDec 08, 2021 G122413
B2215056Certificate of AnalysisDec 08, 2021 G122413
B2215057Certificate of AnalysisDec 08, 2021 G122413
G2318126Certificate of AnalysisDec 08, 2021 G122413
G2318129Certificate of AnalysisDec 08, 2021 G122413
G2318170Certificate of AnalysisDec 08, 2021 G122413

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Chemical and Physical Properties

Melt Point(°C)166°C

Safety and Hazards(GHS)

Pictogram(s) GHS08,   GHS07
Signal Danger
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

H360:May damage fertility or the unborn child

H361:Suspected of damaging fertility or the unborn child

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P203:Obtain, read and follow all safety instructions before use.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P318:if exposed or concerned, get medical advice.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

WGK Germany 3
RTECS GU6496000
Reaxy-Rn 2359739
Merck Index 4319

Related Documents

References

1. Dooley DJ, Mieske CA, Borosky SA.  (2000)  Inhibition of K(+)-evoked glutamate release from rat neocortical and hippocampal slices by gabapentin..  Neurosci Lett,  280  (2): (107-10).  [PMID:10686389]
2. Dooley DJ, Donovan CM, Pugsley TA.  (2000)  Stimulus-dependent modulation of [(3)H]norepinephrine release from rat neocortical slices by gabapentin and pregabalin..  J Pharmacol Exp Ther,  295  (3): (1086-93).  [PMID:11082444]
3. Maneuf YP, Hughes J, McKnight AT.  (2001)  Gabapentin inhibits the substance P-facilitated K(+)-evoked release of [(3)H]glutamate from rat caudial trigeminal nucleus slices..  Pain,  93  (2): (191-6).  [PMID:11427331]
4. Hendrich J, Van Minh AT, Heblich F, Nieto-Rostro M, Watschinger K, Striessnig J, Wratten J, Davies A, Dolphin AC.  (2008)  Pharmacological disruption of calcium channel trafficking by the alpha2delta ligand gabapentin..  Proc Natl Acad Sci USA,  105  (9): (3628-33).  [PMID:18299583]
5. Mortell KH, Anderson DJ, Lynch 3rd JJ, Nelson SL, Sarris K, McDonald H, Sabet R, Baker S, Honore P, Lee CH et al..  (2006)  Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels..  Bioorg Med Chem Lett,  16  (5): (1138-41).  [PMID:16380257]
6. Meleine M, Boudieu L, Gelot A, Muller E, Lashermes A, Matricon J, Silberberg C, Theodorou V, Eschalier A, Ardid D et al..  (2016)  Comparative effects of α2δ-1 ligands in mouse models of colonic hypersensitivity..  World J Gastroenterol,  22  (31): (7111-23).  [PMID:27610021]
7. Anfuso CD, Olivieri M, Fidilio A, Lupo G, Rusciano D, Pezzino S, Gagliano C, Drago F, Bucolo C.  (2017)  Gabapentin Attenuates Ocular Inflammation: In vitro and In vivo Studies..  Front Pharmacol,  (3): (173).  [PMID:28420991]
8. Gee NS, Brown JP, Dissanayake VU, Offord J, Thurlow R, Woodruff GN.  (1996)  The novel anticonvulsant drug, gabapentin (Neurontin), binds to the alpha2delta subunit of a calcium channel..  J Biol Chem,  271  (10): (5768-76).  [PMID:8621444]
9. Brown JP, Dissanayake VU, Briggs AR, Milic MR, Gee NS.  (1998)  Isolation of the [3H]gabapentin-binding protein/alpha 2 delta Ca2+ channel subunit from porcine brain: development of a radioligand binding assay for alpha 2 delta subunits using [3H]leucine..  Anal Biochem,  255  (2): (236-43).  [PMID:9451509]
10. Andresen L et al..  (2014)  Gabapentin attenuates hyperexcitability in the freeze-lesion model of developmental cortical malformation..  Neurobiol Dis,  71  (305-16).  [PMID:25158291]

Solution Calculators