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Galangin - 98%, high purity , CAS No.548-83-4, Antagonist of A 1 receptor;Antagonist of A 2A receptor;Antagonist of A 3 receptor;Channel blocker of TRPC5

Moligand™
≥98%

CAS#: 548-83-4
Formula: C₁₅H₁₀O₅
Molecular Weight: 270.24
Beilstein Registry Number: 272179
EC Number: 208-960-4
MDL number: MFCD00006833
PubChem CID: 5281616

Item Number

G100561

Grouped product items
SKU	Size	Availability	Price
G100561-25mg	25mg	In stock	$42.90
G100561-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$119.90
G100561-250mg	250mg	In stock	$239.90

TRPC5 inhibitor; also induces autophagy

View related series

A1 receptor Antagonist A2A receptor Antagonist A3 receptor Antagonist TRPC5 Channel blocker

Basic Description

Synonyms	Galangin\|548-83-4\|Norizalpinin\|3,5,7-Trihydroxyflavone\|3,5,7-Trihydroxy-2-phenyl-4H-chromen-4-one\|3,5,7-triOH-Flavone\|4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-phenyl-\|3,5,7-Trihydroxy-2-phenyl-4-benzopyrone\|3,5,7-trihydroxy-2-phenylchromen-4-one\|FLAVONE,
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	TRPC5 inhibitor. Inhibits Ca2+entry into TRPC5 expressing cells. Inhibits LPS-induced expression of TNFα, IL-6, IL-1β, COX2 and iNOS,in vitro. Attenuates microglial activation, loss of dopaminergic neurons and motor dysfunction in a LPS-induced rat model
Shipped In	Normal
Grade	Moligand™
Action Type	ANTAGONIST, CHANNEL BLOCKER
Mechanism of action	Antagonist of A 1 receptor;Antagonist of A 2A receptor;Antagonist of A 3 receptor;Channel blocker of TRPC5

Names and Identifiers

IUPAC Name	3,5,7-trihydroxy-2-phenylchromen-4-one
INCHI	InChI=1S/C15H10O5/c16-9-6-10(17)12-11(7-9)20-15(14(19)13(12)18)8-4-2-1-3-5-8/h1-7,16-17,19H
InChi Key	VCCRNZQBSJXYJD-UHFFFAOYSA-N
Canonical SMILES	C1=CC=C(C=C1)C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O
Isomeric SMILES	C1=CC=C(C=C1)C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O
WGK Germany	3
RTECS	LK9275500
PubChem CID	5281616
Molecular Weight	270.24
Beilstein	272179

Database links

PubChem CID	5281616
ChEBI	CHEBI:5262
CAS Registry No.	548-83-4
Wikipedia	Galangin
ChEMBL Ligand	CHEMBL309490
BindingDB Ligand	50049391
RCSB PDB Ligand	KMC, KMC
GPCRdb Ligand	galangin

Certificates

Certificate of Analysis(COA)

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To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

11 results found

Lot Number	Certificate Type	Date	Item
G2431225	Certificate of Analysis	Aug 08, 2024	G100561
G2431226	Certificate of Analysis	Aug 08, 2024	G100561
G2431227	Certificate of Analysis	Aug 08, 2024	G100561
G2431228	Certificate of Analysis	Aug 08, 2024	G100561
E2327432	Certificate of Analysis	Jun 05, 2023	G100561
E2327436	Certificate of Analysis	Jun 05, 2023	G100561
E2327438	Certificate of Analysis	Jun 05, 2023	G100561
G2401031	Certificate of Analysis	Jun 05, 2023	G100561
I2203223	Certificate of Analysis	Sep 13, 2022	G100561
I2203224	Certificate of Analysis	Sep 13, 2022	G100561
I2203225	Certificate of Analysis	Sep 13, 2022	G100561

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 27.02, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 13.51, Max Conc. mM: 50
Sensitivity	Light Sensitive,Air Sensitive
Melt Point(°C)	218-225℃

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
WGK Germany	3
RTECS	LK9275500
Merck Index	4339

References

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59. Jeong-Eun Huh,In-Tae Jung,Junyoung Choi,Yong-Hyeon Baek,Jae-Dong Lee,Dong-Suk Park,Do-Young Choi. (2012-09-19) The natural flavonoid galangin inhibits osteoclastic bone destruction and osteoclastogenesis by suppressing NF-κB in collagen-induced arthritis and bone marrow-derived macrophages.. European journal of pharmacology, 698 ((1-3)): (57-66). [PMID:22985747]
60. Chang Hwa Jung,Soo Jeong Jang,Jiyun Ahn,So Young Gwon,Tae-Il Jeon,Tae Wan Kim,Tae Youl Ha. (2012-11-07) Alpinia officinarum inhibits adipocyte differentiation and high-fat diet-induced obesity in mice through regulation of adipogenesis and lipogenesis.. Journal of medicinal food, 15 ((11)): (959-967). [PMID:23126661]
61. Shaojing Li,Chuanhong Wu,Li Zhu,Jian Gao,Jing Fang,Defeng Li,Meihong Fu,Rixin Liang,Lan Wang,Ming Cheng,Hongjun Yang. (2012-11-13) By improving regional cortical blood flow, attenuating mitochondrial dysfunction and sequential apoptosis galangin acts as a potential neuroprotective agent after acute ischemic stroke.. Molecules (Basel, Switzerland), 17 ((11)): (13403-13423). [PMID:23143152]
62. Wang-Jian Zha,Yan Qian,Yi Shen,Qiang Du,Fei-Fei Chen,Zhen-Zhen Wu,Xiao Li,Mao Huang. (2013-06-14) Galangin Abrogates Ovalbumin-Induced Airway Inflammation via Negative Regulation of NF-κB.. Evidence-based complementary and alternative medicine : eCAM, 2013 (767689-767689). [PMID:23762160]
63. Ye-Ri Kim,Min-A Kim,Hyun-Ju Cho,Se-Kyung Oh,In-Kyu Lee,Un-Kyung Kim,Kyu-Yup Lee. (2016-01-19) Galangin prevents aminoglycoside-induced ototoxicity by decreasing mitochondrial production of reactive oxygen species in mouse cochlear cultures.. Toxicology letters, 245 (78-85). [PMID:26778349]
64. Mattia Mori,Luca Tottone,Deborah Quaglio,Nadezda Zhdanovskaya,Cinzia Ingallina,Marisa Fusto,Francesca Ghirga,Giovanna Peruzzi,Maria Elisa Crestoni,Fabrizio Simeoni,Francesca Giulimondi,Claudio Talora,Bruno Botta,Isabella Screpanti,Rocco Palermo. (2017-05-21) Identification of a novel chalcone derivative that inhibits Notch signaling in T-cell acute lymphoblastic leukemia.. Scientific reports, 7 ((1)): (2213-2213). [PMID:28526832]
65. Yu-Ching Huang,Ming-Shiun Tsai,Pei-Chi Hsieh,Jheng-Hong Shih,Tsu-Shing Wang,Yi-Chun Wang,Ting-Hui Lin,Sue-Hong Wang. (2017-06-01) Galangin ameliorates cisplatin-induced nephrotoxicity by attenuating oxidative stress, inflammation and cell death in mice through inhibition of ERK and NF-kappaB signaling.. Toxicology and applied pharmacology, 329 (128-139). [PMID:28558962]
66. Anela Topcagic,Sanja Cavar Zeljkovic,Erna Karalija,Semira Galijasevic,Emin Sofic. (2017-06-08) Evaluation of phenolic profile, enzyme inhibitory and antimicrobial activities of Nigella sativa L. seed extracts.. Bosnian journal of basic medical sciences, 17 ((4)): (286-294). [PMID:28590231]
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68. Wen-Wei Zou,Su-Ping Xu. (2017-11-16) Galangin inhibits the cell progression and induces cell apoptosis through activating PTEN and Caspase-3 pathways in retinoblastoma.. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 97 (851-863). [PMID:29136761]
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