Galantamine Hydrobromide - 10mM in Water, high purity , CAS No.1953-04-4

  • 10mM in Water
Item Number
G422386
Grouped product items
SKUSizeAvailabilityPrice Qty
G422386-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$69.90

Alkaloid acetylcholinesterase inhibitor

Basic Description

SynonymsGalanthamine hydrobromide | Galantamine hydrobromide | 1953-04-4 | Reminyl | Nivalin | Nivaline | Lycoremine hydrobromide | Jilkon hydrobromide | Razadyne | Tamilin | Galanthamine (hydrobromide) | MJ4PTD2VVW | Nivaline (pharmaceutical) | Jilcon hydrobromide | (-)-Galantamine Hydrobr
Specifications & Purity10mM in Water
Biochemical and Physiological MechanismsGalanthamine hydrobromide is a long-acting, centrally active acetylcholinesterase inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. Galanthamine hydrobromide prevents β-amyloid-induced apoptosis in SH-SY5Y and
Storage TempProtected from light,Store at -80°C
Shipped InIce chest + Ice pads

Associated Targets(Human)

ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BCHE Tclin Butyrylcholinesterase (7174 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Homo sapiens (32628 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SH-SY5Y (11521 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GMNN Tbio Geminin (128009 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
IDH1 Tclin Isocitrate dehydrogenase [NADP] cytoplasmic (40980 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Pseudomonas aeruginosa (123386 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Klebsiella pneumoniae (43867 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Acinetobacter baumannii (41033 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Escherichia coli (133304 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cryptococcus neoformans (21258 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Candida albicans (78123 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BCHE Cholinesterase (8742 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Blood (6 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name (1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetracyclo[8.6.1.01,12.06,17]heptadeca-6(17),7,9,15-tetraen-14-ol;hydrobromide
INCHI InChI=1S/C17H21NO3.BrH/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17;/h3-6,12,14,19H,7-10H2,1-2H3;1H/t12-,14-,17-;/m0./s1
InChi Key QORVDGQLPPAFRS-XPSHAMGMSA-N
Canonical SMILES CN1CCC23C=CC(CC2OC4=C(C=CC(=C34)C1)OC)O.Br
Isomeric SMILES CN1CC[C@@]23C=C[C@@H](C[C@@H]2OC4=C(C=CC(=C34)C1)OC)O.Br
WGK Germany 3
RTECS DF8075000
PubChem CID 121587
Molecular Weight 368.27
Beilstein 27(3/4)2184
Reaxy-Rn 3787265

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SensitivityLight Sensitive,Hygroscopic,Heat Sensitive
Specific Rotation[α]-95 ° (C=1.4, H2O)
Melt Point(°C)256°C

Safety and Hazards(GHS)

Pictogram(s) GHS06
Signal Danger
Hazard Statements

H301:Toxic if swallowed

Precautionary Statements

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P270:Do not eat, drink or smoke when using this product.

P330:Rinse mouth.

P301+P316:IF SWALLOWED: Get emergency medical help immediately.

WGK Germany 3
RTECS DF8075000
Reaxy-Rn 3787265
Merck Index 4340

Related Documents

Citations of This Product

1. Yijing Liao, Xi Mai, Xiaqing Wu, Xing Hu, Xiaoqiao Luo, Guowen Zhang.  (2022)  Exploring the Inhibition of Quercetin on Acetylcholinesterase by Multispectroscopic and In Silico Approaches and Evaluation of Its Neuroprotective Effects on PC12 Cells.  MOLECULES,  27  (22): (7971).  [PMID:36432070] [10.3390/molecules27227971]
2. Yijing Liao, Xing Hu, Junhui Pan, Guowen Zhang.  (2022)  Inhibitory Mechanism of Baicalein on Acetylcholinesterase: Inhibitory Interaction, Conformational Change, and Computational Simulation.  Foods,  11  (2): (168).  [PMID:35053900] [10.3390/foods11020168]
3. Pei-Pei WANG, Guo-Wei ZHAO, Wen XIA, En-Ji HAN, Lan XIANG.  (2014)  A new flavonol C-glycoside and a rare bioactive lignanamide from Piper wallichii Miq. Hand.-Mazz.  Chinese Journal of Natural Medicines,  12  (377).  [PMID:24856762] [10.1016/S1875-5364(14)60047-9]
4. Ping Chen, Pei-Pei Wang, Ze-Zhao Jiao, Lan Xiang.  (2014)  Sesquiterpenoids from the Fruits of Alpinia oxyphylla and Their Anti-Acetylcholinesterase Activity.  HELVETICA CHIMICA ACTA,  97  (3): (388-397).  [PMID:] [10.1002/hlca.201300234]

References

1. Yijing Liao, Xi Mai, Xiaqing Wu, Xing Hu, Xiaoqiao Luo, Guowen Zhang.  (2022)  Exploring the Inhibition of Quercetin on Acetylcholinesterase by Multispectroscopic and In Silico Approaches and Evaluation of Its Neuroprotective Effects on PC12 Cells.  MOLECULES,  27  (22): (7971).  [PMID:36432070] [10.3390/molecules27227971]
2. Yijing Liao, Xing Hu, Junhui Pan, Guowen Zhang.  (2022)  Inhibitory Mechanism of Baicalein on Acetylcholinesterase: Inhibitory Interaction, Conformational Change, and Computational Simulation.  Foods,  11  (2): (168).  [PMID:35053900] [10.3390/foods11020168]
3. Pei-Pei WANG, Guo-Wei ZHAO, Wen XIA, En-Ji HAN, Lan XIANG.  (2014)  A new flavonol C-glycoside and a rare bioactive lignanamide from Piper wallichii Miq. Hand.-Mazz.  Chinese Journal of Natural Medicines,  12  (377).  [PMID:24856762] [10.1016/S1875-5364(14)60047-9]
4. Ping Chen, Pei-Pei Wang, Ze-Zhao Jiao, Lan Xiang.  (2014)  Sesquiterpenoids from the Fruits of Alpinia oxyphylla and Their Anti-Acetylcholinesterase Activity.  HELVETICA CHIMICA ACTA,  97  (3): (388-397).  [PMID:] [10.1002/hlca.201300234]

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