Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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G423611-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $79.90 |
Potent selective\xa0acetylcholinesterase inhibitor.
Synonyms | galanthamine | Galantamine | 357-70-0 | (-)-Galanthamine | Lycoremin | Lycoremine | Jilkon | Galantamina | Galanthaminum | Galantamin | (-)-Galantamine | Galantaminum | Razadyne | Galantaminum [INN-Latin] | Galantamina [INN-Spanish] | (+/-)-Galantamine | Razadyne ER | Bodamine | NSC 100058 | |
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Specifications & Purity | Moligand™, 10mM in DMSO |
Biochemical and Physiological Mechanisms | Galanthamine is a selective acetylcholinesterase inhibitor that blocks the breakdown of acetylcholine, allowing receptors to be activated for longer periods of time.Potent selective acetylcholinesterase inhibitor (IC 50 =\xa0410 nM). Greater than 50-fold |
Storage Temp | Store at -80°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Product Description | Galanthamine is a long-acting, centrally active acetylcholinesterase(AChE) inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. |
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IUPAC Name | (1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetracyclo[8.6.1.01,12.06,17]heptadeca-6(17),7,9,15-tetraen-14-ol |
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INCHI | InChI=1S/C17H21NO3/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17/h3-6,12,14,19H,7-10H2,1-2H3/t12-,14-,17-/m0/s1 |
InChi Key | ASUTZQLVASHGKV-JDFRZJQESA-N |
Canonical SMILES | CN1CCC23C=CC(CC2OC4=C(C=CC(=C34)C1)OC)O |
Isomeric SMILES | CN1CC[C@@]23C=C[C@@H](C[C@@H]2OC4=C(C=CC(=C34)C1)OC)O |
PubChem CID | 9651 |
Molecular Weight | 287.35 |
Enter Lot Number to search for COA:
Pictogram(s) | GHS06, GHS08, GHS09, GHS07 |
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Signal | Danger |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H301:Toxic if swallowed H331:Toxic if inhaled H373:Causes damage to organs through prolonged or repeated exposure H317:May cause an allergic skin reaction H400:Very toxic to aquatic life H410:Very toxic to aquatic life with long lasting effects H301+H331:Toxic if swallowed or if inhaled |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P391:Collect spillage. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P316:Get emergency medical help immediately. P319:Get medical help if you feel unwell. |
1. Haobin Shi, Yuhong Zheng, Mengyao Wu, Li Fu. (2019) Graphene Ink Modified Glassy Carbon Electrode as electrochemical sensor for Galantamine Determination. International Journal of Electrochemical Science, 14 (1546). [PMID:] |
2. Jia Song, Jiaying Yu, Kai Sun, Zhixin Chen, Xiaoxiao Xing, Yumeng Yang, Chunyu Sun, Zhifei Wang. (2023) Preparation of a Highly Selective “Off-On” Rhodamine-Based Fluorescent Probe for the Specific Determination of Carboxylesterase 2 and Cell Imaging. ANALYTICAL LETTERS, 56 (15): (2457-2472). [PMID:] |
3. Zhixu Chen, Jincai Wang, Jiaming Yuan, Zhen Wang, Zhengchao Tu, Jacques Crommen, Wenhui Luo, Jialiang Guo, Tingting Zhang, Zhengjin Jiang. (2023) Rapid screening of neuraminidase inhibitors using an at-line nanofractionation platform involving parallel oseltamivir-sensitive/resistant neuraminidase bioassays. JOURNAL OF CHROMATOGRAPHY A, 1687 (463693). [PMID:36516530] |
1. Haobin Shi, Yuhong Zheng, Mengyao Wu, Li Fu. (2019) Graphene Ink Modified Glassy Carbon Electrode as electrochemical sensor for Galantamine Determination. International Journal of Electrochemical Science, 14 (1546). [PMID:] |
2. Jia Song, Jiaying Yu, Kai Sun, Zhixin Chen, Xiaoxiao Xing, Yumeng Yang, Chunyu Sun, Zhifei Wang. (2023) Preparation of a Highly Selective “Off-On” Rhodamine-Based Fluorescent Probe for the Specific Determination of Carboxylesterase 2 and Cell Imaging. ANALYTICAL LETTERS, 56 (15): (2457-2472). [PMID:] |
3. Zhixu Chen, Jincai Wang, Jiaming Yuan, Zhen Wang, Zhengchao Tu, Jacques Crommen, Wenhui Luo, Jialiang Guo, Tingting Zhang, Zhengjin Jiang. (2023) Rapid screening of neuraminidase inhibitors using an at-line nanofractionation platform involving parallel oseltamivir-sensitive/resistant neuraminidase bioassays. JOURNAL OF CHROMATOGRAPHY A, 1687 (463693). [PMID:36516530] |