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Galeterone - ≥98%, high purity , Cytochrome P450 17A1 inhibitor, CAS No.851983-85-2, Cytochrome P450 17A1 inhibitor

Moligand™
≥98%

CAS#: 851983-85-2
Formula: C₂₆H₃₂N₂O
Molecular Weight: 388.56
PubChem CID: 11188409

Item Number

T127853

Grouped product items
SKU	Size	Availability	Price
T127853-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$64.90
T127853-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$292.90
T127853-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$489.90

CYP17 inhibitor; also androgen receptor antagonist

View related series

Androgen receptor Antagonist CYP17A1 Inhibitor

Basic Description

Synonyms	Galeterone\|851983-85-2\|TOK-001\|VN/124-1\|Galaterone\|TOK 001\|VN/124\|Galeterone [USAN]\|TOK-001(Galeterone)\|Tok-001 (galeterone)\|VN 124\|VN-124-1\|WA33E149SW\|(3S,8R,9S,10R,13S,14S)-17-(benzimidazol-1-yl)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclo
Specifications & Purity	≥98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ANTAGONIST, INHIBITOR
Mechanism of action	Cytochrome P450 17A1 inhibitor
Product Description	TOK-001 (VN/124-1; Galeterone) is a multifunctional antiandrogen and CYP17 inhibitor(IC50=47 nM) in castration resistant prostate cancer (CRPC). An antagonist to LNCaP AR

Associated Targets

CYP21A2 Tchem Steroid 21-hydroxylase 3 Activities

Discover Target: CYP21A2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP17A1 Tclin Steroid 17-alpha-hydroxylase/17,20 lyase 7 Activities

Discover Target: CYP17A1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AR Tclin Androgen receptor 1 Activities

Discover Target: AR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(3S,8R,9S,10R,13S,14S)-17-(benzimidazol-1-yl)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-3-ol
INCHI	InChI=1S/C26H32N2O/c1-25-13-11-18(29)15-17(25)7-8-19-20-9-10-24(26(20,2)14-12-21(19)25)28-16-27-22-5-3-4-6-23(22)28/h3-7,10,16,18-21,29H,8-9,11-15H2,1-2H3/t18-,19-,20-,21-,25-,26-/m0/s1
InChi Key	PAFKTGFSEFKSQG-PAASFTFBSA-N
Canonical SMILES	CC12CCC(CC1=CCC3C2CCC4(C3CC=C4N5C=NC6=CC=CC=C65)C)O
Isomeric SMILES	C[C@]12CC[C@@H](CC1=CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC=C4N5C=NC6=CC=CC=C65)C)O
PubChem CID	11188409
Molecular Weight	388.56

PubChem CID

ChEMBL Ligand

CAS Registry No.

Wikipedia

RCSB PDB Ligand

Certificates

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1 results found

Lot Number	Certificate Type	Date	Item
E1717029	Certificate of Analysis	Jan 12, 2023	T127853

Safety and Hazards(GHS)

Pictogram(s)	GHS08
Signal	Warning
Hazard Statements	H361:Suspected of damaging fertility or the unborn child H371:May cause damage to organs H361fd:Suspected of damaging fertility; Suspected of damaging the unborn child
Precautionary Statements	P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P270:Do not eat, drink or smoke when using this product. P203:Obtain, read and follow all safety instructions before use. P318:if exposed or concerned, get medical advice. P308+P316:IF exposed or concerned: Get emergency medical help immediately.

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