The store will not work correctly when cookies are disabled.
JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.
Galeterone - ≥98%, high purity , Cytochrome P450 17A1 inhibitor, CAS No.851983-85-2, Cytochrome P450 17A1 inhibitor
CYP17 inhibitor; also androgen receptor antagonist
Basic Description Synonyms GTPL8638 | (3beta)-17-(1h-benzimidazol-1-yl)androsta-5,16-dien-3-ol | (3S,8R,9S,10R,13S,14S)-17-(benzimidazol-1-yl)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-3-ol | TOK 001 | AS-56204 | Galeterone, >=98% (HPLC) | Galeter Specifications & Purity Moligand™, ≥98% Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type ANTAGONIST, INHIBITOR Mechanism of action Cytochrome P450 17A1 inhibitor Product Description TOK-001 (VN/124-1; Galeterone) is a multifunctional antiandrogen and CYP17 inhibitor(IC50=47 nM) in castration resistant prostate cancer (CRPC).
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name (3S,8R,9S,10R,13S,14S)-17-(benzimidazol-1-yl)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-3-ol INCHI InChI=1S/C26H32N2O/c1-25-13-11-18(29)15-17(25)7-8-19-20-9-10-24(26(20,2)14-12-21(19)25)28-16-27-22-5-3-4-6-23(22)28/h3-7,10,16,18-21,29H,8-9,11-15H2,1-2H3/t18-,19-,20-,21-,25-,26-/m0/s1 InChi Key PAFKTGFSEFKSQG-PAASFTFBSA-N Canonical SMILES CC12CCC(CC1=CCC3C2CCC4(C3CC=C4N5C=NC6=CC=CC=C65)C)O Isomeric SMILES C[C@]12CC[C@@H](CC1=CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC=C4N5C=NC6=CC=CC=C65)C)O PubChem CID 11188409 Molecular Weight 388.56
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 19.43, Max Conc. mM: 50; Solvent:ethanol, Max Conc. mg/mL: 19.43, Max Conc. mM: 50
Safety and Hazards(GHS) Pictogram(s) GHS08 Signal Warning Hazard Statements H361: Suspected of damaging fertility or the unborn child
H371: May cause damage to organs
H361fd: Suspected of damaging fertility; Suspected of damaging the unborn child
Precautionary Statements P280: Wear protective gloves/protective clothing/eye protection/face protection.
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P270: Do not eat, drink or smoke when using this product.
P203: Obtain, read and follow all safety instructions before use.
P318: if exposed or concerned, get medical advice.
P308+P316: IF exposed or concerned: Get emergency medical help immediately.
Solution Calculators Molarity Calculator Determine the necessary mass, volume, or concentration for preparing a solution.
Dilution Calculator Determine the dilution needed to prepare a stock solution.
Reconstitution Calculator
E1717029