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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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G276337-100μg | 100μg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $516.90 | |
G276337-500μg | 500μg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $2,040.90 |
Selective STAT3 signaling inhibitor
Synonyms | (4S,5aR,7aR,7bS)-7b-Hydroxy-4-methyl-5,5a,6,7,7a,7b-hexahydroindeno[1,7-bc]furan-2(4H)-one |
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Specifications & Purity | ≥95% |
Biochemical and Physiological Mechanisms | Selective STAT3 signaling inhibitor (IC 50 = 0.25-0.5 μM, IL-6-mediated JAK/STAT signaling). Selectively blocks binding of activated STAT3 dimers to their DNA binding sites without affecting phosphorylation of the STAT3 transcription factor. Induces apopt |
Storage Temp | Store at -20°C,Desiccated |
Shipped In | Ice chest + Ice pads |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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IUPAC Name | (4R,7R,9S,11S)-11-hydroxy-9-methyl-3-oxatricyclo[5.3.1.04,11]undec-1(10)-en-2-one |
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INCHI | InChI=1S/C11H14O3/c1-6-4-7-2-3-9-11(7,13)8(5-6)10(12)14-9/h5-7,9,13H,2-4H2,1H3/t6-,7+,9+,11-/m0/s1 |
InChi Key | SOIISBQQYAGDKM-QJSROADHSA-N |
Canonical SMILES | CC1CC2CCC3C2(C(=C1)C(=O)O3)O |
Isomeric SMILES | C[C@H]1C[C@H]2CC[C@@H]3[C@]2(C(=C1)C(=O)O3)O |
PubChem CID | 11310070 |
Molecular Weight | 194.23 |
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Solubility | Soluble in ethanol and in DMSO |
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