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Galiellalactone - ≥95%, high purity , CAS No.133613-71-5

  • ≥95%
Item Number
G276337
Grouped product items
SKUSizeAvailabilityPrice Qty
G276337-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$516.90
G276337-500μg
500μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,040.90

Selective STAT3 signaling inhibitor

Basic Description

Synonyms(4S,5aR,7aR,7bS)-7b-Hydroxy-4-methyl-5,5a,6,7,7a,7b-hexahydroindeno[1,7-bc]furan-2(4H)-one
Specifications & Purity≥95%
Biochemical and Physiological MechanismsSelective STAT3 signaling inhibitor (IC 50 = 0.25-0.5 μM, IL-6-mediated JAK/STAT signaling). Selectively blocks binding of activated STAT3 dimers to their DNA binding sites without affecting phosphorylation of the STAT3 transcription factor. Induces apopt
Storage TempStore at -20°C,Desiccated
Shipped InIce chest + Ice pads
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

Associated Targets

STAT3 Tchem Signal transducer and activator of transcription 3 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

STAT1 Tchem Signal transducer and activator of transcription 1-alpha/beta 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

STAT5A Tchem Signal transducer and activator of transcription 5A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name (4R,7R,9S,11S)-11-hydroxy-9-methyl-3-oxatricyclo[5.3.1.04,11]undec-1(10)-en-2-one
INCHI InChI=1S/C11H14O3/c1-6-4-7-2-3-9-11(7,13)8(5-6)10(12)14-9/h5-7,9,13H,2-4H2,1H3/t6-,7+,9+,11-/m0/s1
InChi Key SOIISBQQYAGDKM-QJSROADHSA-N
Canonical SMILES CC1CC2CCC3C2(C(=C1)C(=O)O3)O
Isomeric SMILES C[C@H]1C[C@H]2CC[C@@H]3[C@]2(C(=C1)C(=O)O3)O
PubChem CID 11310070
Molecular Weight 194.23

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilitySoluble in ethanol and in DMSO

Related Documents

Solution Calculators