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Gambogenic acid - 98%, high purity , CAS No.173932-75-7

≥98%

CAS#: 173932-75-7
Formula: C₃₈H₄₆O₈
Molecular Weight: 630.77
PubChem CID: 10794070

Item Number

G414318

Grouped product items
SKU	Size	Availability	Price
G414318-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$125.90
G414318-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$265.90
G414318-10mg	10mg	In stock	$451.90
G414318-25mg	25mg	In stock	$1,017.90

FGFR Inhibitors

Basic Description

Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Gambogenic Acid, identified from Gamboge, is an inhibitor of the FGFR signaling pathway in erlotinib-resistant non-small-cell lung cancer (NSCLC) and exhibits anti-tumor effects. Gambogenic acid acts is also an effective inhibitor of EZH2 that specificall
Storage Temp	Protected from light,Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	Information Gambogenic acid is an active ingredient in gamboge, with anticancer activity. Gambogenic acid acts as an effective inhibitor of EZH2, specifically and covalently binds to Cys668 within the EZH2-SET domain, and induces EZH2 ubiquitination. Targets FGFR ; EZH2

ALogP

7.717

HBD Count

Rotatable Bond

Associated Targets

PTPN1 Tchem Tyrosine-protein phosphatase non-receptor type 1 0 Activities

Discover Target: PTPN1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TXN2 Tbio Thioredoxin, mitochondrial 0 Activities

Discover Target: TXN2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TXN Tchem Thioredoxin 0 Activities

Discover Target: TXN

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(Z)-4-[(1S,2S,13S,15R)-7-[(2E)-3,7-dimethylocta-2,6-dienyl]-6,8-dihydroxy-17,17-dimethyl-5-(3-methylbut-2-enyl)-10,14-dioxo-3,16-dioxapentacyclo[11.4.1.02,11.02,15.04,9]octadeca-4,6,8,11-tetraen-15-yl]-2-methylbut-2-enoic acid
INCHI	InChI=1S/C38H46O8/c1-20(2)10-9-11-22(5)13-15-25-30(39)26(14-12-21(3)4)33-29(31(25)40)32(41)27-18-24-19-28-36(7,8)46-37(34(24)42,38(27,28)45-33)17-16-23(6)35(43)44/h10,12-13,16,18,24,28,39-40H,9,11,14-15,17,19H2,1-8H3,(H,43,44)/b22-13+,23-16-/t24-,28+,37+,38-/m1/s1
InChi Key	RCWNBHCZYXWDOV-VSFMGBBVSA-N
Canonical SMILES	CC(=CCCC(=CCC1=C(C(=C2C(=C1O)C(=O)C3=CC4CC5C3(O2)C(C4=O)(OC5(C)C)CC=C(C)C(=O)O)CC=C(C)C)O)C)C
Isomeric SMILES	CC(=CCC/C(=C/CC1=C(C(=C2C(=C1O)C(=O)C3=C[C@@H]4C[C@@H]5[C@@]3(O2)[C@](C4=O)(OC5(C)C)C/C=C(/C)\C(=O)O)CC=C(C)C)O)/C)C
PubChem CID	10794070
Molecular Weight	630.77

Certificates

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3 results found

Lot Number	Certificate Type	Date	Item
G2216351	Certificate of Analysis	Jun 04, 2022	G414318
G2216391	Certificate of Analysis	Jun 04, 2022	G414318
G2216401	Certificate of Analysis	Jun 04, 2022	G414318

Solubility

Solubility (25°C) In vitro DMSO: 100 mg/mL (158.53 mM);

Sensitivity

light sensitive

DMSO(mg / mL) Max Solubility

DMSO(mM) Max Solubility

15.8537135992394

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