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Ganetespib (STA-9090) - ≥98%, high purity , Heat shock protein HSP90 inhibitor, CAS No.888216-25-9, Heat shock protein HSP90 inhibitor
Basic Description Synonyms EX-A250 | 3-(2,4-Dihydroxy-5-isopropylphenyl)-4-(1-methyl-1H-indol-5-yl)-1H-1,2,4-triazol-5(4H)-one | AS-35117 | CS-0697 | FT-0700397 | 3-(2,4-dihydroxy-5-propan-2-ylphenyl)-4-(1-methylindol-5-yl)-1H-1,2,4-triazol-5-one | HMS3654K12 | BCP22669 | CHEBI:177 Specifications & Purity ≥98% Biochemical and Physiological Mechanisms Ganetespib is a unique triazolone-containing Hsp90 inhibitor with an IC50 of 4 nM for OSA 8 cells. Ganetespib (STA-9090) is a synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Hsp90 inhibitor Ganet Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Action Type INHIBITOR Mechanism of action Heat shock protein HSP90 inhibitor Note Refer to SDS for further information Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. Product Description Ganetespib(STA-9090) is a unique triazolone-containing Hsp90 inhibitor with an IC50 of 4 nM in OSA 8 cells.
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 3-(2,4-dihydroxy-5-propan-2-ylphenyl)-4-(1-methylindol-5-yl)-1H-1,2,4-triazol-5-one INCHI InChI=1S/C20H20N4O3/c1-11(2)14-9-15(18(26)10-17(14)25)19-21-22-20(27)24(19)13-4-5-16-12(8-13)6-7-23(16)3/h4-11,25-26H,1-3H3,(H,22,27) InChi Key RVAQIUULWULRNW-UHFFFAOYSA-N Canonical SMILES CC(C)C1=C(C=C(C(=C1)C2=NNC(=O)N2C3=CC4=C(C=C3)N(C=C4)C)O)O Isomeric SMILES CC(C)C1=C(C=C(C(=C1)C2=NNC(=O)N2C3=CC4=C(C=C3)N(C=C4)C)O)O PubChem CID 135564985 Molecular Weight 364.4
Chemical and Physical Properties Solubility DMSO 40 mg/mL Water <1 mg/mL Ethanol 9 mg/mL
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P362+P364: Take off contaminated clothing and wash it before reuse.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P337+P317: If eye irritation persists: Get medical help.
P332+P317: If skin irritation occurs: Get medical help.
P319: Get medical help if you feel unwell.
Citations of This Product 1. Lingyun Ruan, Yuanyuan Cao, Caixia Ren, Huan Li, Xuesong Feng, Rongzhang Hao. (2023) Hyaluronic Acid-Functionalized Polydopamine Nanoparticles Augment Photothermal Therapy via Synergetic Tumor-Targeting and Heat Shock Protein Inhibition. ACS Applied Nano Materials, (15): [PMID:21211811 ] [10.1021/acsanm.3c04655 ]
References 1. Lingyun Ruan, Yuanyuan Cao, Caixia Ren, Huan Li, Xuesong Feng, Rongzhang Hao. (2023) Hyaluronic Acid-Functionalized Polydopamine Nanoparticles Augment Photothermal Therapy via Synergetic Tumor-Targeting and Heat Shock Protein Inhibition. ACS Applied Nano Materials, (15): [PMID:21211811 ] [10.1021/acsanm.3c04655 ]
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