Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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G275450-5mg | 5mg | In stock | $64.90 | |
G275450-10mg | 10mg | In stock | $103.90 | |
G275450-25mg | 25mg | In stock | $234.90 | |
G275450-50mg | 50mg | In stock | $391.90 | |
G275450-100mg | 100mg | In stock | $705.90 | |
G275450-250mg | 250mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $1,587.90 | |
G275450-1g | 1g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $5,715.90 |
Selective GLI1 and 2 inhibitor
Synonyms | NSC 136476 | GANT61 | NCIStruc1_001747 | NCGC00014352-03 | GANT61(NSC 136476) | CHEBI:94276 | DTXSID50329591 | GANT 61(NSC 136476) | 2,2''-(2-(pyridin-4-yl)dihydropyrimidine-1,3(2H,4H)-diyl)bis(methylene)bis(N,N-dimethylaniline) | 2,2'-(2-(pyridin-4-yl)di |
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Specifications & Purity | ≥98% |
Biochemical and Physiological Mechanisms | GANT61 blocks hedgehog pathway signaling by inhibiting the transcripional activity of Gli1 (IC50 = 5 μM). GANT 61 led to a regression of 22Rv1 human prostate tumor cell xenografts in nude mice. |
Storage Temp | Store at -20°C,Desiccated |
Shipped In | Ice chest + Ice pads |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 2-[[3-[[2-(dimethylamino)phenyl]methyl]-2-pyridin-4-yl-1,3-diazinan-1-yl]methyl]-N,N-dimethylaniline |
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INCHI | InChI=1S/C27H35N5/c1-29(2)25-12-7-5-10-23(25)20-31-18-9-19-32(27(31)22-14-16-28-17-15-22)21-24-11-6-8-13-26(24)30(3)4/h5-8,10-17,27H,9,18-21H2,1-4H3 |
InChi Key | KVQOGDQTWWCZFX-UHFFFAOYSA-N |
Canonical SMILES | CN(C)C1=CC=CC=C1CN2CCCN(C2C3=CC=NC=C3)CC4=CC=CC=C4N(C)C |
Isomeric SMILES | CN(C)C1=CC=CC=C1CN2CCCN(C2C3=CC=NC=C3)CC4=CC=CC=C4N(C)C |
PubChem CID | 421610 |
Molecular Weight | 429.61 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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A2214479 | Certificate of Analysis | Jul 12, 2023 | G275450 |
A2214480 | Certificate of Analysis | Jul 12, 2023 | G275450 |
A2214472 | Certificate of Analysis | Oct 21, 2022 | G275450 |
A2214473 | Certificate of Analysis | Oct 21, 2022 | G275450 |
A2214474 | Certificate of Analysis | Oct 21, 2022 | G275450 |
A2214475 | Certificate of Analysis | Oct 21, 2022 | G275450 |
A2214476 | Certificate of Analysis | Oct 21, 2022 | G275450 |
Solubility | Soluble in DMSO to 50 mM and in ethanol to 100 mM |
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1. Dong H et al.. (2019) GLI1 activation by non-classical pathway integrin avß3/ERK1/2 maintains stem cell-like phenotype of multicellular aggregates in gastric cancer peritoneal metastasis.. Cell Death Dis, 10 (8): (574). [PMID:31366904] |
2. Zhang C et al.. (2016) Gli1 promotes colorectal cancer metastasis in a Foxm1-dependent manner by activating EMT and PI3K-AKT signaling.. Oncotarget, 7 (52): (86134-86147). [PMID:27863385] |
3. Zeng C et al.. (2020) Hedgehog signaling activation required for glypican-6-mediated regulation of invasion, migration, and epithelial-mesenchymal transition of gastric cancer cells.. Biosci Rep, 40 (6): [PMID:32478377] |
4. Qi H et al.. (2019) Inactivation of Nell-1 in Chondrocytes Significantly Impedes Appendicular Skeletogenesis.. J Bone Miner Res, 34 (3): (533-546). [PMID:30352124] |
5. Xu Y et al.. (2014) Inhibition of the Hedgehog pathway induces autophagy in pancreatic ductal adenocarcinoma cells.. Oncol Rep, 31 (2): (707-12). [PMID:24297612] |
6. Shao JB et al.. (2017) The mechanism of epithelial-mesenchymal transition induced by TGF-ß1 in neuroblastoma cells.. Int J Oncol, 50 (5): (1623-1633). [PMID:28393230] |