Garcinol - ≥95%, high purity , CAS No.78824-30-3, Inhibitor of E1A binding protein p300;Inhibitor of lysine acetyltransferase 2B

Item Number
G275583
Grouped product items
SKUSizeAvailabilityPrice Qty
G275583-1mg
1mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$53.90
G275583-5mg
5mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$184.90
G275583-25mg
25mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$649.90

Potent HAT p300 and PCAF inhibitor. Pleiotropic agent.

Basic Description

SynonymsGarcinol | CHEBI:5276 | MFCD03700761 | CS-0028887 | (1R,5R,7R)-3-(3,4-Dihydroxybenzyol)-4-hydroxy-8,8-dimethyl-1,7-bis(3-methyl-2-buten-1-yl)-5-[(2S)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]bicyclo[3.3.1]non-3-ene-2,9-dione | MS-30635 | C09929 | (1S,3Z,
Specifications & PurityMoligand™, ≥95%
Biochemical and Physiological MechanismsPotent histone acetyltransferase p300 and PCAF inhibitor (IC 50 values are 7 and 5 μM for p300 and PCAF respectively). Pleiotropic agent. Strongly inhibits chromatin transcription and induces apoptosis. Inhibits histone acetylation in vivo .
Storage TempStore at -20°C,Desiccated
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of E1A binding protein p300;Inhibitor of lysine acetyltransferase 2B
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

Associated Targets(Human)

EP300 Tchem Histone acetyltransferase p300 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KAT2B Tchem Histone acetyltransferase KAT2B (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name (1S,3Z,5R,7R)-3-[(3,4-dihydroxyphenyl)-hydroxymethylidene]-6,6-dimethyl-5,7-bis(3-methylbut-2-enyl)-1-[(2S)-5-methyl-2-prop-1-en-2-ylhex-4-enyl]bicyclo[3.3.1]nonane-2,4,9-trione
INCHI InChI=1S/C38H50O6/c1-22(2)11-13-27(25(7)8)20-37-21-28(15-12-23(3)4)36(9,10)38(35(37)44,18-17-24(5)6)34(43)31(33(37)42)32(41)26-14-16-29(39)30(40)19-26/h11-12,14,16-17,19,27-28,39-41H,7,13,15,18,20-21H2,1-6,8-10H3/b32-31-/t27-,28+,37+,38-/m0/s1
InChi Key DTTONLKLWRTCAB-BZSUNBQASA-N
Canonical SMILES CC(=CCC1CC2(C(=O)C(=C(C3=CC(=C(C=C3)O)O)O)C(=O)C(C2=O)(C1(C)C)CC=C(C)C)CC(CC=C(C)C)C(=C)C)C
Isomeric SMILES CC(=CC[C@@H]1C[C@@]2(C(=O)/C(=C(\C3=CC(=C(C=C3)O)O)/O)/C(=O)[C@@](C2=O)(C1(C)C)CC=C(C)C)C[C@H](CC=C(C)C)C(=C)C)C
PubChem CID 5281560
Molecular Weight 602.8

Certificates

Certificate of Analysis(COA)

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12 results found

Lot NumberCertificate TypeDateItem
G2410324Certificate of AnalysisJun 28, 2024 G275583
G2410325Certificate of AnalysisJun 28, 2024 G275583
G2410326Certificate of AnalysisJun 28, 2024 G275583
G2410365Certificate of AnalysisJun 28, 2024 G275583
G2410366Certificate of AnalysisJun 28, 2024 G275583
G2410367Certificate of AnalysisJun 28, 2024 G275583
E23101156Certificate of AnalysisFeb 21, 2024 G275583
E23101157Certificate of AnalysisFeb 21, 2024 G275583
G2214500Certificate of AnalysisApr 18, 2023 G275583
G2214501Certificate of AnalysisApr 18, 2023 G275583
G2214507Certificate of AnalysisApr 18, 2023 G275583
E23101150Certificate of AnalysisNov 23, 2022 G275583

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Chemical and Physical Properties

SolubilitySoluble in DMSO to 25 mM and in ethanol to 25 mM
SensitivityMoisture sensitive

Related Documents

References

1. Dahlin JL, Nelson KM, Strasser JM, Barsyte-Lovejoy D, Szewczyk MM, Organ S, Cuellar M, Singh G, Shrimp JH, Nguyen N et al..  (2017)  Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors..  Nat Commun,  (1): (1527).  [PMID:29142305]
2. Gehring KB et al..  (2016)  Involvement of phosphorylated Apis mellifera CREB in gating a honeybee's behavioral response to an external stimulus..  Learn Mem,  23  (5): (195-207).  [PMID:27084927]

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