Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
SKU | Size | Availability | Price | Qty |
---|---|---|---|---|
G275583-1mg | 1mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $53.90 | |
G275583-5mg | 5mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $184.90 | |
G275583-25mg | 25mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $649.90 |
Potent HAT p300 and PCAF inhibitor. Pleiotropic agent.
Synonyms | Garcinol | CHEBI:5276 | MFCD03700761 | CS-0028887 | (1R,5R,7R)-3-(3,4-Dihydroxybenzyol)-4-hydroxy-8,8-dimethyl-1,7-bis(3-methyl-2-buten-1-yl)-5-[(2S)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]bicyclo[3.3.1]non-3-ene-2,9-dione | MS-30635 | C09929 | (1S,3Z, |
---|---|
Specifications & Purity | Moligand™, ≥95% |
Biochemical and Physiological Mechanisms | Potent histone acetyltransferase p300 and PCAF inhibitor (IC 50 values are 7 and 5 μM for p300 and PCAF respectively). Pleiotropic agent. Strongly inhibits chromatin transcription and induces apoptosis. Inhibits histone acetylation in vivo . |
Storage Temp | Store at -20°C,Desiccated |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of E1A binding protein p300;Inhibitor of lysine acetyltransferase 2B |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
IUPAC Name | (1S,3Z,5R,7R)-3-[(3,4-dihydroxyphenyl)-hydroxymethylidene]-6,6-dimethyl-5,7-bis(3-methylbut-2-enyl)-1-[(2S)-5-methyl-2-prop-1-en-2-ylhex-4-enyl]bicyclo[3.3.1]nonane-2,4,9-trione |
---|---|
INCHI | InChI=1S/C38H50O6/c1-22(2)11-13-27(25(7)8)20-37-21-28(15-12-23(3)4)36(9,10)38(35(37)44,18-17-24(5)6)34(43)31(33(37)42)32(41)26-14-16-29(39)30(40)19-26/h11-12,14,16-17,19,27-28,39-41H,7,13,15,18,20-21H2,1-6,8-10H3/b32-31-/t27-,28+,37+,38-/m0/s1 |
InChi Key | DTTONLKLWRTCAB-BZSUNBQASA-N |
Canonical SMILES | CC(=CCC1CC2(C(=O)C(=C(C3=CC(=C(C=C3)O)O)O)C(=O)C(C2=O)(C1(C)C)CC=C(C)C)CC(CC=C(C)C)C(=C)C)C |
Isomeric SMILES | CC(=CC[C@@H]1C[C@@]2(C(=O)/C(=C(\C3=CC(=C(C=C3)O)O)/O)/C(=O)[C@@](C2=O)(C1(C)C)CC=C(C)C)C[C@H](CC=C(C)C)C(=C)C)C |
PubChem CID | 5281560 |
Molecular Weight | 602.8 |
PubChem CID | 174159 |
---|---|
CAS Registry No. | 78824-30-3 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
G2410324 | Certificate of Analysis | Jun 28, 2024 | G275583 |
G2410325 | Certificate of Analysis | Jun 28, 2024 | G275583 |
G2410326 | Certificate of Analysis | Jun 28, 2024 | G275583 |
G2410365 | Certificate of Analysis | Jun 28, 2024 | G275583 |
G2410366 | Certificate of Analysis | Jun 28, 2024 | G275583 |
G2410367 | Certificate of Analysis | Jun 28, 2024 | G275583 |
E23101156 | Certificate of Analysis | Feb 21, 2024 | G275583 |
E23101157 | Certificate of Analysis | Feb 21, 2024 | G275583 |
G2214500 | Certificate of Analysis | Apr 18, 2023 | G275583 |
G2214501 | Certificate of Analysis | Apr 18, 2023 | G275583 |
G2214507 | Certificate of Analysis | Apr 18, 2023 | G275583 |
E23101150 | Certificate of Analysis | Nov 23, 2022 | G275583 |
Solubility | Soluble in DMSO to 25 mM and in ethanol to 25 mM |
---|---|
Sensitivity | Moisture sensitive |
1. Dahlin JL, Nelson KM, Strasser JM, Barsyte-Lovejoy D, Szewczyk MM, Organ S, Cuellar M, Singh G, Shrimp JH, Nguyen N et al.. (2017) Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors.. Nat Commun, 8 (1): (1527). [PMID:29142305] |
2. Gehring KB et al.. (2016) Involvement of phosphorylated Apis mellifera CREB in gating a honeybee's behavioral response to an external stimulus.. Learn Mem, 23 (5): (195-207). [PMID:27084927] |