Grouped product items

SKU

Size

Availability

Price

Qty

G330521-5mg

5mg

Available within 4-8 weeks(?)

$74.90

G330521-25mg

25mg

Available within 4-8 weeks(?)

$285.90

G330521-50mg

50mg

Available within 4-8 weeks(?)

$513.90

G330521-100mg

100mg

Available within 4-8 weeks(?)

$923.90

Basic Description

Synonyms	DB06160 \| DTXSID30173135 \| J-012614 \| NCGC00015524-01 \| Garenfloxacin \| Garenoxacin [INN:BAN] \| EX-A3040 \| GARENOXACIN [WHO-DD] \| NCGC00181770-01 \| HY-17460 \| BCPP000224 \| Methylcholanthrene;3-MC \| BMS-284756 \| Garenoxacin \| garenoxacino \| 194804-75-6 pou
Specifications & Purity	Moligand™, ≥98%
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Product Description	Garenoxacin is an inhibitor of topoisomerase (Topo) II and acts as a des-F(6)-quinoline actibacterial agent.

Product Properties

pKa	pKa: 6.44 (Predicted), pKa: 8.76 (Predicted)

Associated Targets(Human)

HDAC6 Tclin Histone deacetylase 6 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GLS Tchem Glutaminase kidney isoform, mitochondrial (0 Activities)

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GLS Tchem Glutaminase kidney isoform, mitochondrial (16997 Activities)

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Associated Targets(non-human)

gyrA DNA gyrase subunit A (187 Activities)

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Hdac6 Histone deacetylase 6 (222 Activities)

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Streptococcus sanguinis (314 Activities)

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Streptococcus pneumoniae (31063 Activities)

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Enterococcus (1748 Activities)

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Fusobacterium sp. (55 Activities)

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Streptococcus viridans (303 Activities)

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Chlamydia pneumoniae (241 Activities)

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Helicobacter pylori (3113 Activities)

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Pseudomonas aeruginosa (123386 Activities)

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Burkholderia cepacia (649 Activities)

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Legionella pneumophila (143 Activities)

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Enterobacter cloacae (7976 Activities)

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Klebsiella (302 Activities)

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Klebsiella pneumoniae (43867 Activities)

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Proteus vulgaris (5823 Activities)

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Providencia rettgeri (925 Activities)

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Salmonella typhimurium (15756 Activities)

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Shigella flexneri (1836 Activities)

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Bacteroides fragilis (1445 Activities)

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Bacteroides thetaiotaomicron (562 Activities)

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Parabacteroides distasonis (282 Activities)

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Fusobacterium necrophorum (183 Activities)

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Peptoniphilus asaccharolyticus (368 Activities)

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Peptostreptococcus anaerobius (347 Activities)

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Staphylococcus aureus (210822 Activities)

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Staphylococcus epidermidis (22802 Activities)

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Staphylococcus haemolyticus (1695 Activities)

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Acinetobacter sp. (243 Activities)

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Moraxella catarrhalis (3334 Activities)

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Neisseria gonorrhoeae (1461 Activities)

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Neisseria meningitidis (411 Activities)

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Citrobacter koseri (193 Activities)

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Citrobacter freundii (1864 Activities)

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Klebsiella aerogenes (4963 Activities)

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Escherichia coli (133304 Activities)

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Klebsiella oxytoca (929 Activities)

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Morganella morganii (1291 Activities)

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Proteus mirabilis (3894 Activities)

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Salmonella enteritidis (727 Activities)

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Salmonella typhi (4293 Activities)

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Serratia marcescens (3237 Activities)

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Shigella dysenteriae (933 Activities)

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Shigella sonnei (625 Activities)

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Haemophilus influenzae (8812 Activities)

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Fusobacterium nucleatum (386 Activities)

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Finegoldia magna (323 Activities)

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Staphylococcus warneri (476 Activities)

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Streptococcus salivarius (87 Activities)

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Streptococcus agalactiae (1777 Activities)

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Names and Identifiers

IUPAC Name	1-cyclopropyl-8-(difluoromethoxy)-7-[(1R)-1-methyl-2,3-dihydro-1H-isoindol-5-yl]-4-oxoquinoline-3-carboxylic acid
INCHI	InChI=1S/C23H20F2N2O4/c1-11-15-5-2-12(8-13(15)9-26-11)16-6-7-17-19(21(16)31-23(24)25)27(14-3-4-14)10-18(20(17)28)22(29)30/h2,5-8,10-11,14,23,26H,3-4,9H2,1H3,(H,29,30)/t11-/m1/s1
InChi Key	NJDRXTDGYFKORP-LLVKDONJSA-N
Canonical SMILES	CC1C2=C(CN1)C=C(C=C2)C3=C(C4=C(C=C3)C(=O)C(=CN4C5CC5)C(=O)O)OC(F)F
Isomeric SMILES	C[C@@H]1C2=C(CN1)C=C(C=C2)C3=C(C4=C(C=C3)C(=O)C(=CN4C5CC5)C(=O)O)OC(F)F
PubChem CID	124093
Molecular Weight	426.41

Database links

Antibiotic DB	2031
PubChem CID	124093
ChEMBL Ligand	CHEMBL215303
ChEBI	CHEBI:131716
DrugBank Ligand	DB06160
DrugCentral Ligand	4053
CAS Registry No.	194804-75-6

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot Number	Certificate Type	Date	Item
H2206843	Certificate of Analysis	Jun 17, 2022	G330521
H2206844	Certificate of Analysis	Jun 17, 2022	G330521
H2206845	Certificate of Analysis	Jun 17, 2022	G330521
H2206883	Certificate of Analysis	Jun 17, 2022	G330521

Chemical and Physical Properties

Solubility	DMF (Slightly, Heated), DMSO (Slightly, Heated), Methanol (Slightly, Heated)
Sensitivity	Hygroscopic
Refractive Index	n20D1.63 (Predicted)
Boil Point(°C)	~581.5° C at 760 mmHg (Predicted)
Melt Point(°C)	326.68° C (Predicted)

References

1. Takahata M, Mitsuyama J, Yamashiro Y, Yonezawa M, Araki H, Todo Y, Minami S, Watanabe Y, Narita H. (1999) In vitro and in vivo antimicrobial activities of T-3811ME, a novel des-F(6)-quinolone.. Antimicrob Agents Chemother, 43 (5): (1077-84). [PMID:10223917]
2. Fung-Tomc JC, Minassian B, Kolek B, Huczko E, Aleksunes L, Stickle T, Washo T, Gradelski E, Valera L, Bonner DP. (2000) Antibacterial spectrum of a novel des-fluoro(6) quinolone, BMS-284756.. Antimicrob Agents Chemother, 44 (12): (3351-6). [PMID:11083639]
3. Frechette R. (2001) T-3811. Toyama/Bristol-Myers Squibb.. Curr Opin Investig Drugs, 2 (12): (1706-11). [PMID:11892932]

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Garenoxacin - ≥98%, high purity , CAS No.194804-75-6

Basic Description

Product Properties

Associated Targets(Human)

Associated Targets(non-human)

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Related Documents

References

Solution Calculators

Molarity Calculator

Dilution Calculator

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SKU	Size	Availability	Price
G330521-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$74.90
G330521-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$285.90
G330521-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$513.90
G330521-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$923.90