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Gastric Inhibitory Polypeptide human - ≥95% (HPLC), high purity , CAS No.100040-31-1, Agonist of GIP receptor

Moligand™
≥95%(HPLC)

CAS#: 100040-31-1
Formula: C₂₂₆H₃₃₈N₆₀O₆₆S
Molecular Weight: 4983.53
MDL number: MFCD00081634
PubChem CID: 131954558

Item Number

G118955

Grouped product items
SKU	Size	Availability	Price
G118955-0.5mg	0.5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,244.90
G118955-1mg	1mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$2,240.90
G118955-2.5mg	2.5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$5,040.90
G118955-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$18,144.90

Potent insulinotropic gut hormone; GIP agonist

View related series

GIP receptor Agonist

Basic Description

Synonyms	Glucose-dependent Insulinotropic Peptide
Specifications & Purity	≥95% (HPLC)
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of GIP receptor
Product Description	Amino Acid Sequence Tyr-Ala-Glu-Gly-Thr-Phe-Ile-Ser-Asp-Tyr-Ser-Ile-Ala-Met-Asp-Lys-Ile-His-Gln-Gln-Asp-Phe-Val-Asn-Trp-Leu-Leu-Ala-Gln-Lys-Gly-Lys-Lys-Asn-Asp-Trp-Lys-His-Asn-Ile-Thr-Glnw Gastric Inhibitory Peptide (GIP), human is thought to act as an inhibitor of gastric functions.

Names and Identifiers

IUPAC Name	5-amino-2-[[2-[[2-[[4-amino-2-[[2-[[6-amino-2-[[2-[[2-[[4-amino-2-[[6-amino-2-[[6-amino-2-[[2-[[6-amino-2-[[5-amino-2-[2-[[2-[[2-[[2-[[4-amino-2-[[2-[[2-[[2-[[5-amino-2-[[5-amino-2-[[2-[[2-[[6-amino-2-[[2-[[2-[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[2-[[2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoylamino]-4-carboxybutanoyl]amino]acetyl]amino]-3-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]-3-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]-3-methylpentanoyl]amino]propanoylamino]-4-methylsulfanylbutanoyl]amino]-3-carboxypropanoyl]amino]hexanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-3-carboxypropanoyl]amino]-3-phenylpropanoyl]amino]-3-methylbutanoyl]amino]-4-oxobutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]propanoylamino]-5-oxopentanoyl]amino]hexanoyl]amino]acetyl]amino]hexanoyl]amino]hexanoyl]amino]-4-oxobutanoyl]amino]-3-carboxypropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]hexanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-4-oxobutanoyl]amino]-3-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-5-oxopentanoic acid
INCHI	InChI=1S/C226H338N60O66S/c1-21-113(11)181(285-218(343)165(107-288)278-203(328)150(88-125-60-64-131(292)65-61-125)264-212(337)163(99-179(310)311)274-217(342)164(106-287)279-222(347)183(115(13)23-3)283-215(340)152(87-123-47-29-26-30-48-123)275-224(349)185(120(18)289)280-174(301)105-245-192(317)142(70-75-175(302)303)252-187(312)117(15)248-190(315)134(232)85-124-58-62-130(291)63-59-124)220(345)250-119(17)189(314)254-146(76-82-353-20)199(324)272-160(96-176(304)305)210(335)258-141(57-39-44-81-231)200(325)282-182(114(12)22-2)221(346)276-156(92-129-103-241-109-247-129)206(331)260-144(67-72-167(234)294)197(322)259-145(68-73-168(235)295)198(323)271-161(97-177(306)307)211(336)265-151(86-122-45-27-25-28-46-122)214(339)281-180(112(9)10)219(344)277-158(94-171(238)298)209(334)266-154(90-127-101-243-136-52-34-32-50-133(127)136)205(330)263-149(84-111(7)8)202(327)262-148(83-110(5)6)201(326)249-118(16)188(313)253-143(66-71-166(233)293)196(321)255-137(53-35-40-77-227)191(316)244-104-173(300)251-138(54-36-41-78-228)193(318)256-139(55-37-42-79-229)195(320)269-157(93-170(237)297)208(333)273-162(98-178(308)309)213(338)267-153(89-126-100-242-135-51-33-31-49-132(126)135)204(329)257-140(56-38-43-80-230)194(319)268-155(91-128-102-240-108-246-128)207(332)270-159(95-172(239)299)216(341)284-184(116(14)24-4)223(348)286-186(121(19)290)225(350)261-147(226(351)352)69-74-169(236)296/h25-34,45-52,58-65,100-103,108-121,134,137-165,180-186,242-243,287-292H,21-24,35-44,53-57,66-99,104-107,227-232H2,1-20H3,(H2,233,293)(H2,234,294)(H2,235,295)(H2,236,296)(H2,237,297)(H2,238,298)(H2,239,299)(H,240,246)(H,241,247)(H,244,316)(H,245,317)(H,248,315)(H,249,326)(H,250,345)(H,251,300)(H,252,312)(H,253,313)(H,254,314)(H,255,321)(H,256,318)(H,257,329)(H,258,335)(H,259,322)(H,260,331)(H,261,350)(H,262,327)(H,263,330)(H,264,337)(H,265,336)(H,266,334)(H,267,338)(H,268,319)(H,269,320)(H,270,332)(H,271,323)(H,272,324)(H,273,333)(H,274,342)(H,275,349)(H,276,346)(H,277,344)(H,278,328)(H,279,347)(H,280,301)(H,281,339)(H,282,325)(H,283,340)(H,284,341)(H,285,343)(H,286,348)(H,302,303)(H,304,305)(H,306,307)(H,308,309)(H,310,311)(H,351,352)
InChi Key	MGXWVYUBJRZYPE-UHFFFAOYSA-N
Canonical SMILES	CCC(C)C(C(=O)NC(CC1=CNC=N1)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)N)C(=O)NC(CC(=O)O)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(C(C)C)C(=O)NC(CC(=O)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(CCC(=O)N)C(=O)NC(CCCCN)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CC(=O)N)C(=O)NC(CC(=O)O)C(=O)NC(CC5=CNC6=CC=CC=C65)C(=O)NC(CCCCN)C(=O)NC(CC7=CNC=N7)C(=O)NC(CC(=O)N)C(=O)NC(C(C)CC)C(=O)NC(C(C)O)C(=O)NC(CCC(=O)N)C(=O)O)NC(=O)C(CCCCN)NC(=O)C(CC(=O)O)NC(=O)C(CCSC)NC(=O)C(C)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(CC8=CC=C(C=C8)O)NC(=O)C(CC(=O)O)NC(=O)C(CO)NC(=O)C(C(C)CC)NC(=O)C(CC9=CC=CC=C9)NC(=O)C(C(C)O)NC(=O)CNC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C(CC1=CC=C(C=C1)O)N
PubChem CID	131954558
Molecular Weight	4983.53

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Lot Number	Certificate Type	Date	Item
C1922039	Certificate of Analysis	Jan 19, 2023	G118955

References

1. A J Moody,L Thim,I Valverde. (1984-07-09) The isolation and sequencing of human gastric inhibitory peptide (GIP).. FEBS letters, 172 ((2)): (142-148). [PMID:6745415]
2. Valeriya Lyssenko,Lena Eliasson,Olga Kotova,Kasper Pilgaard,Nils Wierup,Albert Salehi,Anna Wendt,Anna Jonsson,Yang Z De Marinis,Lisa M Berglund,Jalal Taneera,Alexander Balhuizen,Ola Hansson,Peter Osmark,Pontus Dunér,Charlotte Brøns,Alena Stancáková,Johanna Kuusisto,Marco Bugliani,Richa Saxena,Emma Ahlqvist,Timothy J Kieffer,Tiinamaija Tuomi,Bo Isomaa,Olle Melander,Emily Sonestedt,Marju Orho-Melander,Peter Nilsson,Sara Bonetti,Riccardo Bonadonna,Roberto Miccoli,Stefano Delprato,Piero Marchetti,Sten Madsbad,Pernille Poulsen,Allan Vaag,Markku Laakso,Maria F Gomez,Leif Groop. (2011-08-04) Pleiotropic effects of GIP on islet function involve osteopontin.. Diabetes, 60 ((9)): (2424-2433). [PMID:21810601]
3. Nigel Irwin,Jacqueline M E Francis,Peter R Flatt. (2011-08-20) Insulin modulates glucose-dependent insulinotropic polypeptide (GIP) secretion from enteroendocrine K cells in rats.. Biological chemistry, 392 ((10)): (909-918). [PMID:21851286]
4. Priya Sumithran,Luke A Prendergast,Elizabeth Delbridge,Katrina Purcell,Arthur Shulkes,Adamandia Kriketos,Joseph Proietto. (2011-10-28) Long-term persistence of hormonal adaptations to weight loss.. The New England journal of medicine, 365 ((17)): (1597-1604). [PMID:22029981]
5. Jennifer D Könitzer,Shreya Pramanick,Qi Pan,Robert Augustin,Sebastian Bandholtz,William Harriman,Shelley Izquierdo. (2017-01-06) Generation of a highly diverse panel of antagonistic chicken monoclonal antibodies against the GIP receptor.. mAbs, 9 ((3)): (536-549). [PMID:28055305]
6. H Yajima,N Fujii,K Akaji,M Sakurai,M Nomizu,K Mizuta,M Aono,M Moriga,K Inoue,R Hosotani. (1985-08-01) Synthesis of a 42 residue peptide corresponding to the entire amino acid sequence of human GIP.. Chemical & pharmaceutical bulletin, 33 ((8)): (3578-3581). [PMID:3910280]
7. Sabrina Paratore,Maria Teresa Ciotti,Magali Basille,David Vaudry,Antonietta Gentile,Rosalba Parenti,Pietro Calissano,Sebastiano Cavallaro. (2011-09-17) Gastric inhibitory polypeptide and its receptor are expressed in the central nervous system and support neuronal survival.. Central nervous system agents in medicinal chemistry, 11 ((3)): (210-222). [PMID:21919873]

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Gastric Inhibitory Polypeptide human - ≥95% (HPLC), high purity , CAS No.100040-31-1, Agonist of GIP receptor

Basic Description

Associated Targets

GIPR Tchem Gastric inhibitory polypeptide receptor 0 Activities