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GAT100 , CAS No.G610517, Allosteric modulator of CB 1 receptor

Item Number
G610517
Grouped product items
SKUSizeAvailabilityPrice Qty
G610517-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,334.90
G610517-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,420.90

Basic Description

Synonyms5-(cyanosulfanyl)-3-ethyl-N-{2-[4-(piperidin-1-yl)phenyl]ethyl}-1H-indole-2-carboxamide
Specifications & PurityMoligand™
GradeMoligand™
Action TypeALLOSTERIC MODULATOR
Mechanism of actionAllosteric modulator of CB 1 receptor

Associated Targets(Human)

CNR1 Tclin Cannabinoid receptor 1 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 3-Ethyl-5-isothiocyanato-N-[4-(piperidin-1-yl)phenethyl]-1H-indole-2-carboxamide
INCHI InChI=1S/C25H28N4OS/c1-2-21-22-16-20(31-17-26)10-11-23(22)28-24(21)25(30)27-13-12-18-6-8-19(9-7-18)29-14-4-3-5-15-29/h6-11,16,28H,2-5,12-15H2,1H3,(H,27,30)
InChi Key OZEQTGDZTPJNAR-UHFFFAOYSA-N
Canonical SMILES N#CSc1ccc2c(c1)c(CC)c([nH]2)C(=O)NCCc1ccc(cc1)N1CCCCC1
Isomeric SMILES CCC1=C(NC2=C1C=C(C=C2)SC#N)C(=O)NCCC3=CC=C(C=C3)N4CCCCC4
PubChem CID 117923261

Certificates

C of A & Other Certificates

Related Documents

References

1. Kulkarni PM, Kulkarni AR, Korde A, Tichkule RB, Laprairie RB, Denovan-Wright EM, Zhou H, Janero DR, Zvonok N, Makriyannis A et al..  (2016)  Novel Electrophilic and Photoaffinity Covalent Probes for Mapping the Cannabinoid 1 Receptor Allosteric Site(s)..  J Med Chem,  59  (1): (44-60).  [PMID:26529344] [10.1021/op500134e]
2. Laprairie RB, Kulkarni AR, Kulkarni PM, Hurst DP, Lynch D, Reggio PH, Janero DR, Pertwee RG, Stevenson LA, Kelly ME et al..  (2016)  Mapping Cannabinoid 1 Receptor Allosteric Site(s): Critical Molecular Determinant and Signaling Profile of GAT100, a Novel, Potent, and Irreversibly Binding Probe..  ACS Chem Neurosci,  (6): (776-98).  [PMID:27046127] [10.1021/op500134e]

Solution Calculators