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GAT211 - 99%, high purity , CAS No.102704-40-5

  • ≥99%
Item Number
G646624
Grouped product items
SKUSizeAvailabilityPrice Qty
G646624-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$80.90
G646624-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$130.90
G646624-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$280.90
G646624-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$450.90
G646624-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$720.90

Basic Description

Specifications & Purity≥99%
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
Product Description

GAT211 is a cannabinoid 1 receptor (CB1R) positive allosteric modulator (PAM). GAT211 activates cAMP and β-arrestin2 with EC 50 values of 260 nM and 650 nM, respectively. GAT211 inhibits GAT211 can be used for neuropathic and/or inflammatory pain research

In Vitro

GAT211 is stable in both human- and rat-liver microsomal incubations, with t 1/2 of 28.4 min and 8.67 min, repsectively. GAT211 limits dopamine D2 receptor-mediated extracellular regulated kinase (ERK) phosphorylation in Neuro2a cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

GAT211 potentiates the inhibition of electrically evoked vas deferens contraction in the same system (EC 50 =11 nM, E max =70). GAT211 (0.3 mg/kg, 1 mg/kg, 3 mg/kg; 5 mL/kg; ip; 2 doses with 5 min interval) dose-dependently reduced locomotor activity and the acoustic startle response.GAT211 is dissolved in a vehicle of ethanol, kolliphor, and saline at a ratio of 1:1:6 and injected at a volume of 5 mL/kg. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:CB1

Associated Targets(Human)

CNR1 Tclin Cannabinoid receptor 1 (3 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CNR1 Tclin Cannabinoid CB1 receptor (20913 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences
Cannabinoid CB1 receptor agonistAGONISTALA218Cannabinoid CB1 receptorSINGLE PROTEINHomo sapiens

DailyMed: [1]


Cannabinoid CB1 receptor agonistAGONISTALA218Cannabinoid CB1 receptorSINGLE PROTEINHomo sapiens

DailyMed: [1]


PubMed: [1]


Cannabinoid CB1 receptor agonistAGONISTALA218Cannabinoid CB1 receptorSINGLE PROTEINHomo sapiens

PubMed: [1] , [2]


Cannabinoid CB1 receptor antagonistANTAGONISTALA218Cannabinoid CB1 receptorSINGLE PROTEINHomo sapiens

PubMed: [1]


Cannabinoid CB1 receptor antagonistANTAGONISTALA218Cannabinoid CB1 receptorSINGLE PROTEINHomo sapiens

Other: [1]


Cannabinoid CB1 receptor antagonistANTAGONISTALA218Cannabinoid CB1 receptorSINGLE PROTEINHomo sapiens

PubMed: [1] , [2]


Wikipedia: [1]


Cannabinoid CB1 receptor antagonistANTAGONISTALA218Cannabinoid CB1 receptorSINGLE PROTEINHomo sapiens

PubMed: [1]


Cannabinoid CB1 receptor agonistAGONISTALA218Cannabinoid CB1 receptorSINGLE PROTEINHomo sapiens

PubMed: [1]


Wikipedia: [1]


Cannabinoid CB1 receptor antagonistANTAGONISTALA218Cannabinoid CB1 receptorSINGLE PROTEINHomo sapiens

PubMed: [1]


Cannabinoid CB1 receptor inverse agonistINVERSE AGONISTALA218Cannabinoid CB1 receptorSINGLE PROTEINHomo sapiens

PubMed: [1]


Names and Identifiers

IUPAC Name 3-(2-nitro-1-phenylethyl)-2-phenyl-1H-indole
INCHI InChI=1S/C22H18N2O2/c25-24(26)15-19(16-9-3-1-4-10-16)21-18-13-7-8-14-20(18)23-22(21)17-11-5-2-6-12-17/h1-14,19,23H,15H2
InChi Key OHZDCJJHWPHZJD-UHFFFAOYSA-N
Canonical SMILES C1=CC=C(C=C1)C2=C(C3=CC=CC=C3N2)C(C[N+](=O)[O-])C4=CC=CC=C4
Isomeric SMILES C1=CC=C(C=C1)C2=C(C3=CC=CC=C3N2)C(C[N+](=O)[O-])C4=CC=CC=C4
WGK Germany 3
PubChem CID 4402318
Molecular Weight 342.39

Certificates

C of A & Other Certificates

Chemical and Physical Properties

SolubilityDMSO : 100 mg/mL (292.06 mM; Need ultrasonic)

Safety and Hazards(GHS)

WGK Germany 3
RIDADR NONHforallmodesoftransport

Related Documents

Solution Calculators