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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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G646624-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $80.90 | |
G646624-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $130.90 | |
G646624-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $280.90 | |
G646624-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $450.90 | |
G646624-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $720.90 |
Specifications & Purity | ≥99% |
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Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Product Description | GAT211 is a cannabinoid 1 receptor (CB1R) positive allosteric modulator (PAM). GAT211 activates cAMP and β-arrestin2 with EC 50 values of 260 nM and 650 nM, respectively. GAT211 inhibits GAT211 can be used for neuropathic and/or inflammatory pain research In Vitro GAT211 is stable in both human- and rat-liver microsomal incubations, with t 1/2 of 28.4 min and 8.67 min, repsectively. GAT211 limits dopamine D2 receptor-mediated extracellular regulated kinase (ERK) phosphorylation in Neuro2a cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo GAT211 potentiates the inhibition of electrically evoked vas deferens contraction in the same system (EC 50 =11 nM, E max =70). GAT211 (0.3 mg/kg, 1 mg/kg, 3 mg/kg; 5 mL/kg; ip; 2 doses with 5 min interval) dose-dependently reduced locomotor activity and the acoustic startle response.GAT211 is dissolved in a vehicle of ethanol, kolliphor, and saline at a ratio of 1:1:6 and injected at a volume of 5 mL/kg. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:CB1 |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Cannabinoid CB1 receptor agonist | AGONIST | ALA218 | Cannabinoid CB1 receptor | SINGLE PROTEIN | Homo sapiens | DailyMed: [1] | |
Cannabinoid CB1 receptor agonist | AGONIST | ALA218 | Cannabinoid CB1 receptor | SINGLE PROTEIN | Homo sapiens | ||
Cannabinoid CB1 receptor agonist | AGONIST | ALA218 | Cannabinoid CB1 receptor | SINGLE PROTEIN | Homo sapiens | ||
Cannabinoid CB1 receptor antagonist | ANTAGONIST | ALA218 | Cannabinoid CB1 receptor | SINGLE PROTEIN | Homo sapiens | PubMed: [1] | |
Cannabinoid CB1 receptor antagonist | ANTAGONIST | ALA218 | Cannabinoid CB1 receptor | SINGLE PROTEIN | Homo sapiens | Other: [1] | |
Cannabinoid CB1 receptor antagonist | ANTAGONIST | ALA218 | Cannabinoid CB1 receptor | SINGLE PROTEIN | Homo sapiens | ||
Cannabinoid CB1 receptor antagonist | ANTAGONIST | ALA218 | Cannabinoid CB1 receptor | SINGLE PROTEIN | Homo sapiens | PubMed: [1] | |
Cannabinoid CB1 receptor agonist | AGONIST | ALA218 | Cannabinoid CB1 receptor | SINGLE PROTEIN | Homo sapiens | ||
Cannabinoid CB1 receptor antagonist | ANTAGONIST | ALA218 | Cannabinoid CB1 receptor | SINGLE PROTEIN | Homo sapiens | PubMed: [1] | |
Cannabinoid CB1 receptor inverse agonist | INVERSE AGONIST | ALA218 | Cannabinoid CB1 receptor | SINGLE PROTEIN | Homo sapiens | PubMed: [1] |
IUPAC Name | 3-(2-nitro-1-phenylethyl)-2-phenyl-1H-indole |
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INCHI | InChI=1S/C22H18N2O2/c25-24(26)15-19(16-9-3-1-4-10-16)21-18-13-7-8-14-20(18)23-22(21)17-11-5-2-6-12-17/h1-14,19,23H,15H2 |
InChi Key | OHZDCJJHWPHZJD-UHFFFAOYSA-N |
Canonical SMILES | C1=CC=C(C=C1)C2=C(C3=CC=CC=C3N2)C(C[N+](=O)[O-])C4=CC=CC=C4 |
Isomeric SMILES | C1=CC=C(C=C1)C2=C(C3=CC=CC=C3N2)C(C[N+](=O)[O-])C4=CC=CC=C4 |
WGK Germany | 3 |
PubChem CID | 4402318 |
Molecular Weight | 342.39 |
Solubility | DMSO : 100 mg/mL (292.06 mM; Need ultrasonic) |
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WGK Germany | 3 |
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RIDADR | NONHforallmodesoftransport |