Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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G129827-1g | 1g | In stock | $58.90 | |
G129827-5g | 5g | In stock | $177.90 | |
G129827-10g | 10g | In stock | $320.90 | |
G129827-25g | 25g | In stock | $720.90 |
Fluoroquinolone antibiotic
Synonyms | HMS3259P06 | AM-1155 | Spectrum3_000999 | PD-135432 | CHEBI:5280 | RKL10068 | 1-cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid | AKOS016340697 | AM 1155 | CS-1841 | NC00702 | SCHEMBL22591 | Spectrum5_001468 | HM |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Gatifloxacin is a fluoroquinolone antibiotic, with potent activity against Gram-negative and Gram-positive bacteria. Gatifloxacin also inhibits bacterial topoismerase II (Topo II).Fluoroquinolone antibiotic. Inhibits bacterial DNA gyrase and type II topoi |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Topoisomerase IV inhibitor |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Gatifloxacin is an antibiotic of the fourth-generation fluoroquinolone family, and inhibits the bacterial enzymes DNA gyrase and topoisomerase IV. |
ALogP | -0.7 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 1-cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid |
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INCHI | InChI=1S/C19H22FN3O4/c1-10-8-22(6-5-21-10)16-14(20)7-12-15(18(16)27-2)23(11-3-4-11)9-13(17(12)24)19(25)26/h7,9-11,21H,3-6,8H2,1-2H3,(H,25,26) |
InChi Key | XUBOMFCQGDBHNK-UHFFFAOYSA-N |
Canonical SMILES | CC1CN(CCN1)C2=C(C=C3C(=C2OC)N(C=C(C3=O)C(=O)O)C4CC4)F |
Isomeric SMILES | CC1CN(CCN1)C2=C(C=C3C(=C2OC)N(C=C(C3=O)C(=O)O)C4CC4)F |
PubChem CID | 5379 |
Molecular Weight | 375.39 |
PubChem CID | 5379 |
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CAS Registry No. | 112811-59-3 |
Antibiotic DB | 940 |
DrugCentral Ligand | 1280 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
F2421263 | Certificate of Analysis | Jul 03, 2024 | G129827 |
F2421264 | Certificate of Analysis | Jul 03, 2024 | G129827 |
F2421265 | Certificate of Analysis | Jul 03, 2024 | G129827 |
B1922045 | Certificate of Analysis | Jun 14, 2024 | G129827 |
B2105038 | Certificate of Analysis | Dec 13, 2022 | G129827 |
K2301096 | Certificate of Analysis | Sep 21, 2022 | G129827 |
Solubility | Soluble in water at pH 2-5 (40-60 mg/ml), chloroform, methanol (Sparingly), DMSO (10 mM), and ethanol (<1 mg/mL). |
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Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H302:Harmful if swallowed H312:Harmful in contact with skin H332:Harmful if inhaled |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help. P317:Get emergency medical help. |
1. Jun Guo, Wei Gan, Ruixin Chen, Miao Zhang, Zhaoqi Sun. (2023) Au nanoparticle sensitized blue TiO2 nanorod arrays for efficient Gatifloxacin photodegradation. RSC Advances, 13 (40): (28299-28306). [PMID:37767117] [10.1039/D3RA05552C] |
2. Baisen Chen, Rongxia Tan, Yanhui Zhong, Yufei Hu, Gongke Li. (2024) A chemiluminescence method based on Ce-PA-Tb polymer for rapid determination of difloxacin in aquatic products. TALANTA, 267 (13): (125217). [PMID:37738744] [10.1016/j.talanta.2023.125217] |
3. Guangli Li, Xuan Wan, Yonghui Xia, Du Tuo, Xiaoman Qi, Tianyu Wang, Mohammad Mehmandoust, Nevin Erk, Quanguo He, Qing Li. (2023) Lamellar α-Zirconium Phosphate Nanoparticles Supported on N-Doped Graphene Nanosheets as Electrocatalysts for the Detection of Levofloxacin. ACS Applied Nano Materials, 6 (18): (17040–17052). [PMID:11485546] [10.1021/acsanm.3c03162] |
4. L. Wang, D. Wang, Y. Tao, J. Wang, M. Tian, Q. Liu, Y. Yang, Y. Zou, F. Ke, X. Guo, X. Li, D. Gao. (2023) Phenylboronic acid functionalized high-crystallinity fluorescent covalent organic framework act as a sensing platform with dual performance for rifamycin antibiotics and water and adsorbent for rifamycin antibiotics. Materials Today Chemistry, 32 (101647). [PMID:] [10.1016/j.mtchem.2023.101647] |
5. Yuanqian Xiong, Dong Zhang, Cuizhu Ye, Yu Wang, Xiangrui Deng, Danwen Deng, Chunhong Xiong, Jinsheng Zhang, Qianhui Gu, Ganhui Huang. (2023) Ultra-sensitive detection of ciprofloxacin hydrochloride in milk by molecularly imprinted electrochemical sensor based on S-CoFe-MOFs/AuNPs. JOURNAL OF FOOD COMPOSITION AND ANALYSIS, 122 (105439). [PMID:] [10.1016/j.jfca.2023.105439] |
6. Zhenyu Lu, Gongke Li, Yufei Hu. (2022) A Tb3+ functionalized triazine-porous organic framework as a ratiometric fluorescent sensor for determination of ciprofloxacin in aquatic products. NEW JOURNAL OF CHEMISTRY, 46 (40): (19153-19160). [PMID:] [10.1039/D2NJ03657F] |
7. Jin'ai Chen, Yuting Jin, Taotao Ren, Shuo Wang, Xianghong Wang, Fuyuan Zhang, Yiwei Tang. (2022) A novel terbium (III) and aptamer-based probe for label-free detection of three fluoroquinolones in honey and water samples. FOOD CHEMISTRY, 386 (132751). [PMID:35334319] [10.1016/j.foodchem.2022.132751] |
8. Zhiwen Li, Jiyue Zhang, Qiyao Sun, Wenwen Shi, Tingxian Tao, Yingqiang Fu. (2022) Moxifloxacin detection based on fluorescence resonance energy transfer from carbon quantum dots to moxifloxacin using a ratiometric fluorescence probe. NEW JOURNAL OF CHEMISTRY, 46 (9): (4226-4232). [PMID:] [10.1039/D1NJ05961K] |
9. Xiaojun Dai, Yanfei Wu, Zhuanhong Jia, Chunmiao Bo. (2021) Preparation of water-compatible magnetic imprinted nanospheres using heptakis (β-cyclodextrin-ionic liquid) as functional monomer for selective recognition of fluoroquinolones in water samples. MICROCHEMICAL JOURNAL, 171 (106793). [PMID:] [10.1016/j.microc.2021.106793] |
10. Qi Xue, Cong Wang, Yao Lin, Ting-Fu Jiang, Zhihua Lv. (2021) Determination of fluoroquinolones illegally added in traditional prostate medicines by ultrasonic-assisted dispersive liquid liquid micro-extraction based on deep eutectic solvent combined with quantitative 19F nuclear magnetic resonance method. MICROCHEMICAL JOURNAL, 170 (106725). [PMID:] [10.1016/j.microc.2021.106725] |
11. Xie Yizhen, Li Qiuyi, Qin Lulu, Zhou Xiaobin, Fan Yinming. (2021) Multi-templates surface molecularly imprinted polymer for simultaneous and rapid determination of sulfonamides and quinolones in water: effect of carbon-carbon double bond. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 28 (39): (54950-54959). [PMID:34120285] [10.1007/s11356-021-14794-6] |
12. Fan Zhang, Xiangsheng Han, Chuanlong Guo, Hui Yang, Jun Wang, Xiaochen Wu. (2021) Fibrous aramid hydrogel supported antibacterial agents for accelerating bacterial-infected wound healing. Materials Science & Engineering C-Materials for Biological Applications, 121 (111833). [PMID:33579471] [10.1016/j.msec.2020.111833] |
13. Wei Wang, Pengyin Deng, Xiqing Liu, Yuqin Ma, Yongsheng Yan. (2021) A CsPbBr3 quantum dots/ultra-thin BN fluorescence sensor for stability and highly sensitive detection of tetracycline. MICROCHEMICAL JOURNAL, 162 (105876). [PMID:] [10.1016/j.microc.2020.105876] |
14. Kaili Yu, Mei-E. Yue, Jie Xu, Ting-Fu Jiang. (2020) Determination of fluoroquinolones in milk, honey and water samples by salting out-assisted dispersive liquid-liquid microextraction based on deep eutectic solvent combined with MECC. FOOD CHEMISTRY, 332 (127371). [PMID:32622188] [10.1016/j.foodchem.2020.127371] |
15. Guigang Li, Lingjuan Xu, Menglin Jiang, Xianggen Wu. (2020) Eye drops and eye gels of levofloxacin: comparison of ocular absorption characterizations and therapeutic effects in the treatment of bacterial keratitis in rabbits. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, [PMID:32233932] [10.1080/03639045.2020.1750626] |
16. Rong Shen, Yichang Yu, Rong Lan, Ran Yu, Ze Yuan, Zhining Xia. (2019) The cardiovascular toxicity induced by high doses of gatifloxacin and ciprofloxacin in zebrafish. ENVIRONMENTAL POLLUTION, 254 (112861). [PMID:31454568] [10.1016/j.envpol.2019.07.029] |
17. Zhenping Liu, Mingliang Jin, Han Lu, Jiyuan Yao, Xin Wang, Guofu Zhou, Lingling Shui. (2019) Molecularly imprinted polymer decorated 3D-framework of functionalized multi-walled carbon nanotubes for ultrasensitive electrochemical sensing of Norfloxacin in pharmaceutical formulations and rat plasma. SENSORS AND ACTUATORS B-CHEMICAL, 288 (363). [PMID:] [10.1016/j.snb.2019.02.097] |
18. Huikai Shao, Haibo Zhou, Tingting Zhang, Xianglong Zhao, Zhengjin Jiang, Qiqin Wang. (2019) Preparation of molecularly imprinted hybrid monoliths for the selective detection of fluoroquinolones in infant formula powders. JOURNAL OF CHROMATOGRAPHY A, 1588 (33). [PMID:30587346] [10.1016/j.chroma.2018.12.038] |
19. Chang Liu, Diandian Deng, Di Xu, Kang Wu, Hong Yang, Kang Zhao, Jianguo Li, Anping Deng. (2019) Development of a monoclonal antibody based-ELISA for the detection of chloramphenicol in shrimp, feed and milk samples and validation by LC-MS/MS coupled with immunoaffinity clean-up. Analytical Methods, 11 (4): (507-516). [PMID:] [10.1039/C8AY02284D] |
20. Suyu Ren, Jing Tao, Feng Tan, Ying Cui, Xiaona Li, Jingwen Chen, Xin He, Yi Wang. (2018) Diffusive gradients in thin films based on MOF-derived porous carbon binding gel for in-situ measurement of antibiotics in waters. SCIENCE OF THE TOTAL ENVIRONMENT, 645 (482). [PMID:30029123] [10.1016/j.scitotenv.2018.07.013] |
21. Wang Nan, Wang Yan-Fei, Omer Ahmed M., Ouyang Xiao-kun. (2017) Fabrication of novel surface-imprinted magnetic graphene oxide-grafted cellulose nanocrystals for selective extraction and fast adsorption of fluoroquinolones from water. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 409 (28): (6643-6653). [PMID:28940000] [10.1007/s00216-017-0619-9] |
22. Zhao-Hong Hu, Yan–Fei Wang, Ahmed Mohamed Omer, Xiao–kun Ouyang. (2018) Fabrication of ofloxacin imprinted polymer on the surface of magnetic carboxylated cellulose nanocrystals for highly selective adsorption of fluoroquinolones from water. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 107 (453). [PMID:28890373] [10.1016/j.ijbiomac.2017.09.009] |
23. Yan-Fei Wang, Yang-Guang Wang, Xiao-Kun Ouyang, Li-Ye Yang. (2017) Surface-Imprinted Magnetic Carboxylated Cellulose Nanocrystals for the Highly Selective Extraction of Six Fluoroquinolones from Egg Samples. ACS Applied Materials & Interfaces, 9 (2): (1759–1769). [PMID:28005332] [10.1021/acsami.6b12206] |
24. Muhua Chen, Yuhui Zheng, Jinwei Gao, Qianming Wang. (2016) Novel europium (III)-gatifloxacin complex structure with dual functionality for pH sensing and metal recognition in aqueous environment. OPTICAL MATERIALS, 60 (1). [PMID:] [10.1016/j.optmat.2016.06.051] |
1. Jun Guo, Wei Gan, Ruixin Chen, Miao Zhang, Zhaoqi Sun. (2023) Au nanoparticle sensitized blue TiO2 nanorod arrays for efficient Gatifloxacin photodegradation. RSC Advances, 13 (40): (28299-28306). [PMID:37767117] [10.1039/D3RA05552C] |
2. Baisen Chen, Rongxia Tan, Yanhui Zhong, Yufei Hu, Gongke Li. (2024) A chemiluminescence method based on Ce-PA-Tb polymer for rapid determination of difloxacin in aquatic products. TALANTA, 267 (13): (125217). [PMID:37738744] [10.1016/j.talanta.2023.125217] |
3. Guangli Li, Xuan Wan, Yonghui Xia, Du Tuo, Xiaoman Qi, Tianyu Wang, Mohammad Mehmandoust, Nevin Erk, Quanguo He, Qing Li. (2023) Lamellar α-Zirconium Phosphate Nanoparticles Supported on N-Doped Graphene Nanosheets as Electrocatalysts for the Detection of Levofloxacin. ACS Applied Nano Materials, 6 (18): (17040–17052). [PMID:11485546] [10.1021/acsanm.3c03162] |
4. L. Wang, D. Wang, Y. Tao, J. Wang, M. Tian, Q. Liu, Y. Yang, Y. Zou, F. Ke, X. Guo, X. Li, D. Gao. (2023) Phenylboronic acid functionalized high-crystallinity fluorescent covalent organic framework act as a sensing platform with dual performance for rifamycin antibiotics and water and adsorbent for rifamycin antibiotics. Materials Today Chemistry, 32 (101647). [PMID:] [10.1016/j.mtchem.2023.101647] |
5. Yuanqian Xiong, Dong Zhang, Cuizhu Ye, Yu Wang, Xiangrui Deng, Danwen Deng, Chunhong Xiong, Jinsheng Zhang, Qianhui Gu, Ganhui Huang. (2023) Ultra-sensitive detection of ciprofloxacin hydrochloride in milk by molecularly imprinted electrochemical sensor based on S-CoFe-MOFs/AuNPs. JOURNAL OF FOOD COMPOSITION AND ANALYSIS, 122 (105439). [PMID:] [10.1016/j.jfca.2023.105439] |
6. Zhenyu Lu, Gongke Li, Yufei Hu. (2022) A Tb3+ functionalized triazine-porous organic framework as a ratiometric fluorescent sensor for determination of ciprofloxacin in aquatic products. NEW JOURNAL OF CHEMISTRY, 46 (40): (19153-19160). [PMID:] [10.1039/D2NJ03657F] |
7. Jin'ai Chen, Yuting Jin, Taotao Ren, Shuo Wang, Xianghong Wang, Fuyuan Zhang, Yiwei Tang. (2022) A novel terbium (III) and aptamer-based probe for label-free detection of three fluoroquinolones in honey and water samples. FOOD CHEMISTRY, 386 (132751). [PMID:35334319] [10.1016/j.foodchem.2022.132751] |
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