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Gavestinel - ≥98%(HPLC), high purity , CAS No.153436-38-5

≥98%(HPLC)

CAS#: 153436-38-5
Formula: C₁₈H₁₁Cl₂N₂O₃Na
Molecular Weight: 397.19
PubChem CID: 16759177

Item Number

G288071

Grouped product items
SKU	Size	Availability	Price
G288071-5mg	5mg	In stock	$484.90
G288071-10mg	10mg	In stock	$873.90
G288071-25mg	25mg	In stock	$1,964.90
G288071-50mg	50mg	In stock	$3,535.90
G288071-100mg	100mg	In stock	$6,364.90

Potent and selective NMDA antagonist; acts at the glycine site

Basic Description

Synonyms	Gavestinel\|Gavestinel sodium\|153436-38-5\|GV 150526A\|GV-150526A\|gv150526a\|Gavestinel (sodium salt)\|80W7787JVB\|153436-38-5 (sodium)\|Sodium (E)-4,6-dichloro-3-(3-oxo-3-(phenylamino)prop-1-en-1-yl)-1H-indole-2-carboxylate\|1H-Indole-2-carboxylic acid, 4,6-dich
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	Highly potent and selective non-competitive antagonist acting at the strychnine-insensitive glycine binding site of the NMDA receptor-channel complex (Kd= 0.8 nM). Displays > 1000-fold selectivity over NMDA, AMPA and kainate binding sites. Orally bioavail
Storage Temp	Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads
Product Description	Product description Gavestinel (GV 150526) is a potent, selective, orally active and non-competitive antagonist of NMDA receptor. Gavestinel binds to the glycine site of the NMDA receptor, with a pKi of 8.5. Gavestinel can be used for the research of acute ischemic stroke.

Associated Targets

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Discover Target: CYP3A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HSD17B10 Tchem 3-hydroxyacyl-CoA dehydrogenase type-2 0 Activities

Discover Target: HSD17B10

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KMT2A Tchem Histone-lysine N-methyltransferase 2A 0 Activities

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TSHR Tclin Thyrotropin receptor 0 Activities

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HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD(+)] 0 Activities

Discover Target: HPGD

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ALOX12 Tchem Arachidonate 12-lipoxygenase, 12S-type 0 Activities

Discover Target: ALOX12

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ALOX15B Tchem Arachidonate 15-lipoxygenase B 0 Activities

Discover Target: ALOX15B

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ALOX15 Tchem Arachidonate 15-lipoxygenase 0 Activities

Discover Target: ALOX15

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ALB Tchem Serum albumin 0 Activities

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ALDH1A1 Tchem Retinal dehydrogenase 1 0 Activities

Discover Target: ALDH1A1

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MAPT Tclin Microtubule-associated protein tau 0 Activities

Discover Target: MAPT

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRIN3A Tclin Glutamate receptor ionotropic, NMDA 3A 0 Activities

Discover Target: GRIN3A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRIN1 Tclin Glutamate receptor ionotropic, NMDA 1 0 Activities

Discover Target: GRIN1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KDM4E Tchem Lysine-specific demethylase 4E 0 Activities

Discover Target: KDM4E

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	sodium;3-[(E)-3-anilino-3-oxoprop-1-enyl]-4,6-dichloro-1H-indole-2-carboxylate
INCHI	InChI=1S/C18H12Cl2N2O3.Na/c19-10-8-13(20)16-12(17(18(24)25)22-14(16)9-10)6-7-15(23)21-11-4-2-1-3-5-11;/h1-9,22H,(H,21,23)(H,24,25);/q;+1/p-1/b7-6+;
InChi Key	GRSDSTMFQHAESM-UHDJGPCESA-M
Canonical SMILES	C1=CC=C(C=C1)NC(=O)C=CC2=C(NC3=C2C(=CC(=C3)Cl)Cl)C(=O)[O-].[Na+]
Isomeric SMILES	C1=CC=C(C=C1)NC(=O)/C=C/C2=C(NC3=C2C(=CC(=C3)Cl)Cl)C(=O)[O-].[Na+]
PubChem CID	16759177
Molecular Weight	397.19

Certificates

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10 results found

Lot Number	Certificate Type	Date	Item
G2326460	Certificate of Analysis	Jul 01, 2023	G288071
G2326463	Certificate of Analysis	Jul 01, 2023	G288071
G2326464	Certificate of Analysis	Jul 01, 2023	G288071
G2326472	Certificate of Analysis	Jul 01, 2023	G288071
G2326630	Certificate of Analysis	Jul 01, 2023	G288071
G2326640	Certificate of Analysis	Jul 01, 2023	G288071
G2326650	Certificate of Analysis	Jul 01, 2023	G288071
G2326651	Certificate of Analysis	Jul 01, 2023	G288071
G2326777	Certificate of Analysis	Jul 01, 2023	G288071
G2326782	Certificate of Analysis	Jul 01, 2023	G288071

Solubility

Solvent:DMSO, Max Conc. mg/mL: 15.89, Max Conc. mM: 40

Sensitivity

Moisture sensitive

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