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GDC-0068 - ≥98%, high purity , Serine/threonine-protein kinase AKT inhibitor, CAS No.1001264-89-6, Serine/threonine-protein kinase AKT inhibitor

Moligand™
≥98%

CAS#: 1001264-89-6
Formula: C₂₄H₃₂ClN₅O₂
Molecular Weight: 458
PubChem CID: 24788740

Item Number

G127588

Grouped product items
SKU	Size	Availability	Price
G127588-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$68.90
G127588-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$98.90
G127588-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$222.90
G127588-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$286.90
G127588-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$444.90

Selective Akt1/2/3 inhibitor

View related series

AKT serine/threonine kinase 1 Inhibitor AKT serine/threonine kinase 2 Inhibitor AKT serine/threonine kinase 3 Inhibitor Protein kinase G (PKG) 1 Inhibitor

Basic Description

Synonyms	Ipatasertib\|1001264-89-6\|GDC-0068\|Ipatasertib (GDC-0068)\|RG7440\|(S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one\|RG-7440\|GDC0068\|GDC 0068\|524Y3IB4HQ\|CHEMBL217
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	GDC-0068 is a novel, highly selective oral ATP-competitive inhibitor designed to bind to the 3 isoforms of Akt. GDC-0068 is a highly selective pan-Akt inhibitor targeting Akt1, Akt2 and Akt3 with IC50 of 5 nM, 18 nM and 8 nM, respectively. GDC-0068 inhibi
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Serine/threonine-protein kinase AKT inhibitor
Note	Refer to SDS for further information Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	GDC-0068(RG 7440) is a highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5 nM/18 nM/8 nM, 620-fold selectivity over PKA.

Associated Targets

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PRKG1 Tchem cGMP-dependent protein kinase 1 1 Activities

Discover Target: PRKG1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AKT3 Tchem RAC-gamma serine/threonine-protein kinase 3 Activities

Discover Target: AKT3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AKT2 Tchem RAC-beta serine/threonine-protein kinase 3 Activities

Discover Target: AKT2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AKT1 Tchem RAC-alpha serine/threonine-protein kinase 3 Activities

Discover Target: AKT1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(2S)-2-(4-chlorophenyl)-1-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one
INCHI	InChI=1S/C24H32ClN5O2/c1-15(2)26-13-19(17-4-6-18(25)7-5-17)24(32)30-10-8-29(9-11-30)23-21-16(3)12-20(31)22(21)27-14-28-23/h4-7,14-16,19-20,26,31H,8-13H2,1-3H3/t16-,19-,20-/m1/s1
InChi Key	GRZXWCHAXNAUHY-NSISKUIASA-N
Canonical SMILES	CC1CC(C2=C1C(=NC=N2)N3CCN(CC3)C(=O)C(CNC(C)C)C4=CC=C(C=C4)Cl)O
Isomeric SMILES	C[C@@H]1C[C@H](C2=C1C(=NC=N2)N3CCN(CC3)C(=O)[C@H](CNC(C)C)C4=CC=C(C=C4)Cl)O
PubChem CID	24788740
Molecular Weight	458

PubChem CID

CAS Registry No.

ChEMBL Ligand

RCSB PDB Ligand

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5 results found

Lot Number	Certificate Type	Date	Item
I2207709	Certificate of Analysis	Jul 03, 2024	G127588
I2207711	Certificate of Analysis	Jul 03, 2024	G127588
I2207707	Certificate of Analysis	Jun 17, 2024	G127588
I2207708	Certificate of Analysis	Jun 17, 2024	G127588
I2207710	Certificate of Analysis	Jun 17, 2024	G127588

Solubility

DMSO 92 mg/mL Water <1 mg/mL Ethanol 92 mg/mL

Sensitivity

Moisture sensitive

References

1. Blake JF, Xu R, Bencsik JR, Xiao D, Kallan NC, Schlachter S, Mitchell IS, Spencer KL, Banka AL, Wallace EM et al.. (2012) Discovery and preclinical pharmacology of a selective ATP-competitive Akt inhibitor (GDC-0068) for the treatment of human tumors.. J Med Chem, 55 (18): (8110-27). [PMID:22934575]

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