Skip to the beginning of the images gallery

GDC-0152 - 98%, high purity , CAS No.873652-48-3, Antagonist of baculoviral IAP repeat containing 2;Antagonist of baculoviral IAP repeat containing 3;Antagonist of baculoviral IAP repeat containing 7;Antagonist of X-linked inhibitor of apoptosis

Moligand™
≥98%

CAS#: 873652-48-3
Formula: C₂₅H₃₄N₆O₃S
Molecular Weight: 498.64
PubChem CID: 46940575

Item Number

G129293

Grouped product items
SKU	Size	Availability	Price
G129293-5mg	5mg	In stock	$97.90
G129293-10mg	10mg	In stock	$162.90
G129293-25mg	25mg	In stock	$366.90
G129293-50mg	50mg	In stock	$489.90
G129293-100mg	100mg	In stock	$815.90

View related series

baculoviral IAP repeat containing 2 Antagonist baculoviral IAP repeat containing 3 Antagonist baculoviral IAP repeat containing 7 Antagonist X-linked inhibitor of apoptosis Antagonist

Basic Description

Synonyms	GDC-0152\|873652-48-3\|GDC-0152 free base\|UNII-4KW1M48SHS\|GDC 0152\|4KW1M48SHS\|(s)-1-((s)-2-cyclohexyl-2-((s)-2-(methylamino)propanamido)acetyl)-N-(4-phenyl-1,2,3-thiadiazol-5-yl)pyrrolidine-2-carboxamide\|GDC0152\|CHEMBL2063869\|873652-48-3 (free base)\|(2S)-1-
Specifications & Purity	Moligand™, ≥98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of baculoviral IAP repeat containing 2;Antagonist of baculoviral IAP repeat containing 3;Antagonist of baculoviral IAP repeat containing 7;Antagonist of X-linked inhibitor of apoptosis

Associated Targets

BRD4 Tchem Bromodomain-containing protein 4 0 Activities

Discover Target: BRD4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CDK2 Tchem Cyclin-dependent kinase 2 0 Activities

Discover Target: CDK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FGFR3 Tclin Fibroblast growth factor receptor 3 0 Activities

Discover Target: FGFR3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CSNK1D Tchem Casein kinase I isoform delta 0 Activities

Discover Target: CSNK1D

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRIM24 Tchem Transcription intermediary factor 1-alpha 0 Activities

Discover Target: TRIM24

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MLX Tchem Max-like protein X 1 Activities

Discover Target: MLX

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BRPF1 Tchem Peregrin 0 Activities

Discover Target: BRPF1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BIRC2 Tchem Baculoviral IAP repeat-containing protein 2 4 Activities

Discover Target: BIRC2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BIRC7 Tchem Baculoviral IAP repeat-containing protein 7 2 Activities

Discover Target: BIRC7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BIRC3 Tchem Baculoviral IAP repeat-containing protein 3 4 Activities

Discover Target: BIRC3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AURKA Tchem Aurora kinase A 0 Activities

Discover Target: AURKA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

XIAP Tchem E3 ubiquitin-protein ligase XIAP 10 Activities

Discover Target: XIAP

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ABL1 Tclin Tyrosine-protein kinase ABL1 0 Activities

Discover Target: ABL1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GSK3B Tclin Glycogen synthase kinase-3 beta 0 Activities

Discover Target: GSK3B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPK1 Tchem Mitogen-activated protein kinase 1 0 Activities

Discover Target: MAPK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(2S)-1-[(2S)-2-cyclohexyl-2-[[(2S)-2-(methylamino)propanoyl]amino]acetyl]-N-(4-phenylthiadiazol-5-yl)pyrrolidine-2-carboxamide
INCHI	InChI=1S/C25H34N6O3S/c1-16(26-2)22(32)27-21(18-12-7-4-8-13-18)25(34)31-15-9-14-19(31)23(33)28-24-20(29-30-35-24)17-10-5-3-6-11-17/h3,5-6,10-11,16,18-19,21,26H,4,7-9,12-15H2,1-2H3,(H,27,32)(H,28,33)/t16-,19-,21-/m0/s1
InChi Key	WZRFLSDVFPIXOV-LRQRDZAKSA-N
Canonical SMILES	CC(C(=O)NC(C1CCCCC1)C(=O)N2CCCC2C(=O)NC3=C(N=NS3)C4=CC=CC=C4)NC
Isomeric SMILES	C[C@@H](C(=O)N[C@@H](C1CCCCC1)C(=O)N2CCC[C@H]2C(=O)NC3=C(N=NS3)C4=CC=CC=C4)NC
PubChem CID	46940575
Molecular Weight	498.64

PubChem CID

46940575

ChEMBL Ligand

CHEMBL2063869

CAS Registry No.

873652-48-3

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

10 results found

Lot Number	Certificate Type	Date	Item
H2328282	Certificate of Analysis	Aug 12, 2023	G129293
H2328283	Certificate of Analysis	Aug 12, 2023	G129293
H2328284	Certificate of Analysis	Aug 12, 2023	G129293
H2328285	Certificate of Analysis	Aug 12, 2023	G129293
H2328286	Certificate of Analysis	Aug 12, 2023	G129293
H2328287	Certificate of Analysis	Aug 12, 2023	G129293
H2328288	Certificate of Analysis	Aug 12, 2023	G129293
H2328289	Certificate of Analysis	Aug 12, 2023	G129293
H2328290	Certificate of Analysis	Aug 12, 2023	G129293
H2328291	Certificate of Analysis	Aug 12, 2023	G129293

Solubility

DMSO 99 mg/mL Water 3 mg/mL Ethanol 99 mg/mL

Melt Point(°C)

175-177ºC

References

1. Flygare JA, Beresini M, Budha N, Chan H, Chan IT, Cheeti S, Cohen F, Deshayes K, Doerner K, Eckhardt SG et al.. (2012) Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152).. J Med Chem, 55 (9): (4101-13). [PMID:22413863]

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.