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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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G129293-5mg | 5mg | In stock | $97.90 | |
G129293-10mg | 10mg | In stock | $162.90 | |
G129293-25mg | 25mg | In stock | $366.90 | |
G129293-50mg | 50mg | In stock | $489.90 | |
G129293-100mg | 100mg | In stock | $815.90 |
Synonyms | AC-32972 | Z2235802113 | A14135 | L-PROLINAMIDE, N-METHYL-L-ALANYL-(2S)-2-CYCLOHEXYLGLYCYL-N-(4-PHENYL-1,2,3-THIADIAZOL-5-YL)- | A916910 | EX-A1658 | Q27077778 | SCHEMBL10166489 | UNII-4KW1M48SHS | 873652-48-3 (free base) | Tox21_300414 | SW220303-1 | S70 |
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Specifications & Purity | Moligand™, ≥98% |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | ANTAGONIST |
Mechanism of action | Antagonist of baculoviral IAP repeat containing 2;Antagonist of baculoviral IAP repeat containing 3;Antagonist of baculoviral IAP repeat containing 7;Antagonist of X-linked inhibitor of apoptosis |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | (2S)-1-[(2S)-2-cyclohexyl-2-[[(2S)-2-(methylamino)propanoyl]amino]acetyl]-N-(4-phenylthiadiazol-5-yl)pyrrolidine-2-carboxamide |
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INCHI | InChI=1S/C25H34N6O3S/c1-16(26-2)22(32)27-21(18-12-7-4-8-13-18)25(34)31-15-9-14-19(31)23(33)28-24-20(29-30-35-24)17-10-5-3-6-11-17/h3,5-6,10-11,16,18-19,21,26H,4,7-9,12-15H2,1-2H3,(H,27,32)(H,28,33)/t16-,19-,21-/m0/s1 |
InChi Key | WZRFLSDVFPIXOV-LRQRDZAKSA-N |
Canonical SMILES | CC(C(=O)NC(C1CCCCC1)C(=O)N2CCCC2C(=O)NC3=C(N=NS3)C4=CC=CC=C4)NC |
Isomeric SMILES | C[C@@H](C(=O)N[C@@H](C1CCCCC1)C(=O)N2CCC[C@H]2C(=O)NC3=C(N=NS3)C4=CC=CC=C4)NC |
PubChem CID | 46940575 |
Molecular Weight | 498.64 |
PubChem CID | 46940575 |
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ChEMBL Ligand | CHEMBL2063869 |
CAS Registry No. | 873652-48-3 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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H2328282 | Certificate of Analysis | Aug 12, 2023 | G129293 |
H2328283 | Certificate of Analysis | Aug 12, 2023 | G129293 |
H2328284 | Certificate of Analysis | Aug 12, 2023 | G129293 |
H2328285 | Certificate of Analysis | Aug 12, 2023 | G129293 |
H2328286 | Certificate of Analysis | Aug 12, 2023 | G129293 |
H2328287 | Certificate of Analysis | Aug 12, 2023 | G129293 |
H2328288 | Certificate of Analysis | Aug 12, 2023 | G129293 |
H2328289 | Certificate of Analysis | Aug 12, 2023 | G129293 |
H2328290 | Certificate of Analysis | Aug 12, 2023 | G129293 |
H2328291 | Certificate of Analysis | Aug 12, 2023 | G129293 |
Solubility | DMSO 99 mg/mL Water 3 mg/mL Ethanol 99 mg/mL |
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Melt Point(°C) | 175-177ºC |
1. Flygare JA, Beresini M, Budha N, Chan H, Chan IT, Cheeti S, Cohen F, Deshayes K, Doerner K, Eckhardt SG et al.. (2012) Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152).. J Med Chem, 55 (9): (4101-13). [PMID:22413863] [10.1021/op500134e] |