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GDC-0310 - 99%, high purity , CAS No.1788063-52-4

  • ≥99%
Item Number
G650382
Grouped product items
SKUSizeAvailabilityPrice Qty
G650382-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$500.90
G650382-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$850.90

Basic Description

Specifications & Purity≥99%
Biochemical and Physiological MechanismsGDC-0310 is a selective acyl-sulfonamide Na v 1.7 inhibitor, with an IC 50 of 0.6 nM for hNa v 1.7.
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
Product Description

GDC-0310 is a selective acyl-sulfonamide Na v 1.7 inhibitor, with an IC 50 of 0.6 nM for hNa v 1.7

In Vitro

GDC-0310 exhibits an EC 50 of 1.1 μM in vivo and a K i of 1.8 nM for Na v 1.7. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

GDC-0310 shows substantially improved Na v selectivity and ADME properties . GDC-0310 exhibits t1/2 values of 5 h, 46 h and 4.4 h in rat (5 mg/kg, iv), dog (1 mg/kg, iv) and cynomolgus monkeys (2 mg/kg, iv), respectively . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:hNa v 1.4 3.4 nM (IC 50 ) hNa v 1.2 38 nM (IC 50 ) hNa v 1.6 198 nM (IC 50 ) hNa v 1.1 202 nM (IC 50 ) hNa v 1.5 551 nM (IC 50 ) Na v 1.7 0.6 nM (IC 50 )

Associated Targets(Human)

SCN1A Tclin Sodium channel protein type I alpha subunit (483 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SCN5A Tclin Sodium channel protein type V alpha subunit (3462 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SCN7A Tclin Sodium channel protein type VII alpha subunit (136 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SCN1A Tclin Sodium channel protein type 1 subunit alpha/beta-1/beta-2 (42 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SCN5A Tclin Sodium channel protein type 5 subunit alpha/beta-1/beta-2 (42 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Scn2a Sodium channel protein type II alpha subunit (191 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Scn8a Sodium channel protein type VIII alpha subunit (53 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Scn4a Sodium channel protein type IV alpha subunit (55 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences
Sodium channel protein type V alpha subunit blockerBLOCKERALA1980Sodium channel protein type V alpha subunitSINGLE PROTEINHomo sapiens

PubMed: [1]


Wikipedia: [1]


Sodium channel protein type V alpha subunit blockerBLOCKERALA1980Sodium channel protein type V alpha subunitSINGLE PROTEINHomo sapiens

PubMed: [1] , [2]


Sodium channel protein type V alpha subunit blockerBLOCKERALA1980Sodium channel protein type V alpha subunitSINGLE PROTEINHomo sapiens

PubMed: [1]


Sodium channel protein type V alpha subunit blockerBLOCKERALA1980Sodium channel protein type V alpha subunitSINGLE PROTEINHomo sapiens

PubMed: [1]


Sodium channel protein type V alpha subunit blockerBLOCKERALA1980Sodium channel protein type V alpha subunitSINGLE PROTEINHomo sapiens

PubMed: [1] , [2]


Wikipedia: [1]


Sodium channel protein type V alpha subunit blockerBLOCKERALA1980Sodium channel protein type V alpha subunitSINGLE PROTEINHomo sapiens

PubMed: [1] , [2] , [3] , [4] , [5]


Sodium channel protein type V alpha subunit blockerBLOCKERALA1980Sodium channel protein type V alpha subunitSINGLE PROTEINHomo sapiens

EMA: [1]


FDA: [1]


PubMed: [1] , [2] , [3]


Cytochrome P450 3A4 inhibitorINHIBITORALA340Cytochrome P450 3A4SINGLE PROTEINHomo sapiens

PubMed: [1]


Wikipedia: [1]


Names and Identifiers

Canonical SMILES C[C@@H](C1=CC(=CC(=C1)Cl)Cl)N2CCC(CC2)COC3=CC(=C(C=C3C4CC4)C(=O)NS(=O)(=O)C)F
Isomeric SMILES C[C@@H](C1=CC(=CC(=C1)Cl)Cl)N2CCC(CC2)COC3=CC(=C(C=C3C4CC4)C(=O)NS(=O)(=O)C)F
PubChem CID 118110531
Molecular Weight 543.48

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilityDMSO : 4 mg/mL (7.36 mM; ultrasonic and warming and heat to 60°C)

Related Documents

Solution Calculators