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Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SKU | Size | Availability | Price | Qty |
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G650382-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $500.90 | |
G650382-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $850.90 |
Specifications & Purity | ≥99% |
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Biochemical and Physiological Mechanisms | GDC-0310 is a selective acyl-sulfonamide Na v 1.7 inhibitor, with an IC 50 of 0.6 nM for hNa v 1.7. |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Product Description | GDC-0310 is a selective acyl-sulfonamide Na v 1.7 inhibitor, with an IC 50 of 0.6 nM for hNa v 1.7 In Vitro GDC-0310 exhibits an EC 50 of 1.1 μM in vivo and a K i of 1.8 nM for Na v 1.7. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo GDC-0310 shows substantially improved Na v selectivity and ADME properties . GDC-0310 exhibits t1/2 values of 5 h, 46 h and 4.4 h in rat (5 mg/kg, iv), dog (1 mg/kg, iv) and cynomolgus monkeys (2 mg/kg, iv), respectively . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:hNa v 1.4 3.4 nM (IC 50 ) hNa v 1.2 38 nM (IC 50 ) hNa v 1.6 198 nM (IC 50 ) hNa v 1.1 202 nM (IC 50 ) hNa v 1.5 551 nM (IC 50 ) Na v 1.7 0.6 nM (IC 50 ) |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Sodium channel protein type V alpha subunit blocker | BLOCKER | ALA1980 | Sodium channel protein type V alpha subunit | SINGLE PROTEIN | Homo sapiens | ||
Sodium channel protein type V alpha subunit blocker | BLOCKER | ALA1980 | Sodium channel protein type V alpha subunit | SINGLE PROTEIN | Homo sapiens | ||
Sodium channel protein type V alpha subunit blocker | BLOCKER | ALA1980 | Sodium channel protein type V alpha subunit | SINGLE PROTEIN | Homo sapiens | PubMed: [1] | |
Sodium channel protein type V alpha subunit blocker | BLOCKER | ALA1980 | Sodium channel protein type V alpha subunit | SINGLE PROTEIN | Homo sapiens | PubMed: [1] | |
Sodium channel protein type V alpha subunit blocker | BLOCKER | ALA1980 | Sodium channel protein type V alpha subunit | SINGLE PROTEIN | Homo sapiens | ||
Sodium channel protein type V alpha subunit blocker | BLOCKER | ALA1980 | Sodium channel protein type V alpha subunit | SINGLE PROTEIN | Homo sapiens | ||
Sodium channel protein type V alpha subunit blocker | BLOCKER | ALA1980 | Sodium channel protein type V alpha subunit | SINGLE PROTEIN | Homo sapiens | ||
Cytochrome P450 3A4 inhibitor | INHIBITOR | ALA340 | Cytochrome P450 3A4 | SINGLE PROTEIN | Homo sapiens |
Canonical SMILES | C[C@@H](C1=CC(=CC(=C1)Cl)Cl)N2CCC(CC2)COC3=CC(=C(C=C3C4CC4)C(=O)NS(=O)(=O)C)F |
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Isomeric SMILES | C[C@@H](C1=CC(=CC(=C1)Cl)Cl)N2CCC(CC2)COC3=CC(=C(C=C3C4CC4)C(=O)NS(=O)(=O)C)F |
PubChem CID | 118110531 |
Molecular Weight | 543.48 |
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Solubility | DMSO : 4 mg/mL (7.36 mM; ultrasonic and warming and heat to 60°C) |
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