Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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G120180-10mg | 10mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $9.90 | |
G120180-50mg | 50mg | In stock | $11.90 | |
G120180-250mg | 250mg | In stock | $13.90 | |
G120180-1g | 1g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $22.90 | |
G120180-5g | 5g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $72.90 | |
G120180-10g | 10g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $119.90 | |
G120180-25g | 25g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $199.90 |
Potent, specific deoxycytidine analog
Synonyms | EX-A837 | Gemcitabine (as hydrochloride) | Gemcitabine HCL (Gemzar) | INFUGEM | NSC613327 | Gemcitabine hydrochloride [USAN] | LY 188011 hydrochloride | BG164501 | Gemzar (TN) | GEMCITABINE HYDROCHLORIDE [VANDF] | dFdC | dFdCyd | 2′-Deoxy-2′,2′-difluorocy |
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Specifications & Purity | ≥98% |
Biochemical and Physiological Mechanisms | Gemcitabine hydrochloride is used for treatment of non-small cell lung cancer, pancreatic cancer, mammary cancer, ovarian cancer, bladder cancer, nasopharyngeal carcinoma and non-Hodgkin's lymphoma.Deoxycytidine analog that inhibits DNA synthesis. Metabol |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Action Type | INHIBITOR |
Mechanism of action | DNA polymerase (alpha/delta/epsilon) inhibitor |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Gemcitabine Hydrochloride (LY 188011 Hydrochloride) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine Hydrochloride inhibits DNA synthesis and repair, resulting in autophagyand apoptosis.This product is only used for scientific research. |
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Pubchem Sid | 504753714 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504753714 |
IUPAC Name | 4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one;hydrochloride |
INCHI | InChI=1S/C9H11F2N3O4.ClH/c10-9(11)6(16)4(3-15)18-7(9)14-2-1-5(12)13-8(14)17;/h1-2,4,6-7,15-16H,3H2,(H2,12,13,17);1H/t4-,6-,7-;/m1./s1 |
InChi Key | OKKDEIYWILRZIA-OSZBKLCCSA-N |
Canonical SMILES | Cl.NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](CO)[C@@H](O)C2(F)F |
Isomeric SMILES | C1=CN(C(=O)N=C1N)[C@H]2C([C@@H]([C@H](O2)CO)O)(F)F.Cl |
WGK Germany | 3 |
RTECS | HA3840000 |
PubChem CID | 60749 |
Molecular Weight | 299.66 |
Reaxy-Rn | 5386970 |
Find and download the COA for your product by matching the lot number on the packaging.
19 results found
Lot Number | Certificate Type | Date | Item |
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Certificate of Analysis | Jan 20, 2025 | G120180 | |
Certificate of Analysis | Oct 19, 2024 | G120180 | |
Certificate of Analysis | Oct 19, 2024 | G120180 | |
Certificate of Analysis | Oct 19, 2024 | G120180 | |
Certificate of Analysis | Oct 19, 2024 | G120180 | |
Certificate of Analysis | Mar 30, 2024 | G120180 | |
Certificate of Analysis | Mar 30, 2024 | G120180 | |
Certificate of Analysis | Mar 30, 2024 | G120180 | |
Certificate of Analysis | Mar 30, 2024 | G120180 | |
Certificate of Analysis | Mar 30, 2024 | G120180 |
Sensitivity | Heat & Light sensitive;Moisture sensitive |
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Refractive Index | 268 |
Specific Rotation[α] | 48°C |
Melt Point(°C) | 292°C |
Pictogram(s) | GHS08 |
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Signal | Danger |
Hazard Statements | H360:May damage fertility or the unborn child |
Precautionary Statements | P201:Obtain special instructions before use. P308+P313:IF exposed or concerned: Get medical advice/attention. |
WGK Germany | 3 |
RTECS | HA3840000 |
Reaxy-Rn | 5386970 |
Merck Index | 4386 |
Starting at $28.90
1. Zhimei Wang, Yuehuan Zhang, Qing Chen, Xin Xiao, Carl Redshaw. (2023) Preparation of pelargonic acid vesicles and sustained drug release. Canadian Journal of Chemistry, 101 (2): [PMID:] [10.1139/cjc-2022-0075] |
2. Yadong Tang,Boxin Huang,Yuqin Dong,Wenlong Wang,Xi Zheng,Wei Zhou,Kun Zhang,Zhiyun Du. (2017-06-07) Three-dimensional prostate tumor model based on a hyaluronic acid-alginate hydrogel for evaluation of anti-cancer drug efficacy.. Journal of biomaterials science. Polymer edition, 28 ((14)): (1603-1616). [PMID:28583017] |
1. Zhimei Wang, Yuehuan Zhang, Qing Chen, Xin Xiao, Carl Redshaw. (2023) Preparation of pelargonic acid vesicles and sustained drug release. Canadian Journal of Chemistry, 101 (2): [PMID:] [10.1139/cjc-2022-0075] |
2. Yadong Tang,Boxin Huang,Yuqin Dong,Wenlong Wang,Xi Zheng,Wei Zhou,Kun Zhang,Zhiyun Du. (2017-06-07) Three-dimensional prostate tumor model based on a hyaluronic acid-alginate hydrogel for evaluation of anti-cancer drug efficacy.. Journal of biomaterials science. Polymer edition, 28 ((14)): (1603-1616). [PMID:28583017] |