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Gemcitabine hydrochloride - 10mM in Water, high purity , CAS No.122111-03-9

2 Citations

10mM in Water

CAS#: 122111-03-9
Formula: C₉H₁₁F₂N₃O₄·HCl
Molecular Weight: 299.66
PubChem CID: 60749

Item Number

G420950

Grouped product items
SKU	Size	Availability	Price	Qty
G420950-1ml	1ml	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$28.90

Potent, specific deoxycytidine analog

Basic Description

Synonyms	GEMCITABINE HYDROCHLORIDE \| 122111-03-9 \| Gemcitabine HCl \| Gemzar \| LY188011 hydrochloride \| 2'-Deoxy-2',2'-difluorocytidine monohydrochloride \| Cytidine, 2'-deoxy-2',2'-difluoro-, monohydrochloride \| LY-188011 \| Gemcitabine (Hydrochloride) \| UNII-U347PV74IL \| Gemcitabine (
Specifications & Purity	10mM in Water
Biochemical and Physiological Mechanisms	Gemcitabine hydrochloride is used for treatment of non-small cell lung cancer, pancreatic cancer, mammary cancer, ovarian cancer, bladder cancer, nasopharyngeal carcinoma and non-Hodgkin's lymphoma.Deoxycytidine analog that inhibits DNA synthesis. Metabol
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads

Associated Targets(Human)

MCF7 (126967 Activities)

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A549 (127892 Activities)

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HCT-116 (91556 Activities)

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NCI-H460 (60772 Activities)

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A2780 (11979 Activities)

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ABCC2 Tchem Canalicular multispecific organic anion transporter 1 (1191 Activities)

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ABCB11 Tchem Bile salt export pump (2311 Activities)

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ABCC3 Tbio Canalicular multispecific organic anion transporter 2 (718 Activities)

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TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

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ABCC4 Tchem Multidrug resistance-associated protein 4 (785 Activities)

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L02 (4864 Activities)

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Associated Targets(non-human)

TRAMP-C1A (16 Activities)

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C2D cell line (11 Activities)

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C2G cell line (11 Activities)

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TRAMP-C2H (17 Activities)

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Blood (6 Activities)

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SARS-CoV-2 (38078 Activities)

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Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one;hydrochloride
INCHI	InChI=1S/C9H11F2N3O4.ClH/c10-9(11)6(16)4(3-15)18-7(9)14-2-1-5(12)13-8(14)17;/h1-2,4,6-7,15-16H,3H2,(H2,12,13,17);1H/t4-,6-,7-;/m1./s1
InChi Key	OKKDEIYWILRZIA-OSZBKLCCSA-N
Canonical SMILES	Cl.NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](CO)[C@@H](O)C2(F)F
Isomeric SMILES	C1=CN(C(=O)N=C1N)[C@H]2C([C@@H]([C@H](O2)CO)O)(F)F.Cl
WGK Germany	3
RTECS	HA3840000
PubChem CID	60749
Molecular Weight	299.66
Reaxy-Rn	5386970

Certificates

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Chemical and Physical Properties

Sensitivity	Heat & Light sensitive
Refractive Index	268
Specific Rotation[α]	48°C
Melt Point(°C)	292°C

Safety and Hazards(GHS)

Pictogram(s)	GHS08
Signal	Danger
Hazard Statements	H360:May damage fertility or the unborn child
Precautionary Statements	P201:Obtain special instructions before use. P308+P313:IF exposed or concerned: Get medical advice/attention.
WGK Germany	3
RTECS	HA3840000
Reaxy-Rn	5386970
Merck Index	4386

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Zhimei Wang, Yuehuan Zhang, Qing Chen, Xin Xiao, Carl Redshaw. (2023) Preparation of pelargonic acid vesicles and sustained drug release. Canadian Journal of Chemistry, 101 (2): [PMID:] [10.1139/cjc-2022-0075]
2. Yadong Tang,Boxin Huang,Yuqin Dong,Wenlong Wang,Xi Zheng,Wei Zhou,Kun Zhang,Zhiyun Du. (2017-06-07) Three-dimensional prostate tumor model based on a hyaluronic acid-alginate hydrogel for evaluation of anti-cancer drug efficacy.. Journal of biomaterials science. Polymer edition, 28 ((14)): (1603-1616). [PMID:28583017]

References

1. Zhimei Wang, Yuehuan Zhang, Qing Chen, Xin Xiao, Carl Redshaw. (2023) Preparation of pelargonic acid vesicles and sustained drug release. Canadian Journal of Chemistry, 101 (2): [PMID:] [10.1139/cjc-2022-0075]
2. Yadong Tang,Boxin Huang,Yuqin Dong,Wenlong Wang,Xi Zheng,Wei Zhou,Kun Zhang,Zhiyun Du. (2017-06-07) Three-dimensional prostate tumor model based on a hyaluronic acid-alginate hydrogel for evaluation of anti-cancer drug efficacy.. Journal of biomaterials science. Polymer edition, 28 ((14)): (1603-1616). [PMID:28583017]

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Gemcitabine hydrochloride - 10mM in Water, high purity , CAS No.122111-03-9

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Citations of This Product

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator