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Gemfibrozil - ≥99%, high purity , Peroxisome proliferator-activated receptor alpha agonist, CAS No.25812-30-0, Peroxisome proliferator-activated receptor alpha agonist

Moligand™
≥99%

CAS#: 25812-30-0
Formula: C₁₅H₂₂O₃
Molecular Weight: 250.33
EC Number: 247-280-2
MDL number: MFCD00079335
PubChem CID: 3463
PubChem SID: 488179770

Item Number

G129727

Grouped product items
SKU	Size	Availability	Price
G129727-1g	1g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$10.90
G129727-5g	5g	In stock	$25.90
G129727-10g	10g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$46.90
G129727-25g	25g	In stock	$76.90
G129727-100g	100g	In stock	$277.90
G129727-500g	500g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,246.90

PPARα activator

View related series

OATP1B1 Inhibitor OATP1B3 Inhibitor OATP2B1 Inhibitor Peroxisome proliferator-activated receptor-α Agonist

Basic Description

Synonyms	gemfibrozil\|25812-30-0\|5-(2,5-Dimethylphenoxy)-2,2-dimethylpentanoic acid\|Lopid\|Jezil\|Decrelip\|Lipur\|Cholespid\|Fibratol\|Fibrocit\|Gemfibril\|Gemfibromax\|Gemlipid\|Hipolixan\|CI-719\|Gemfibrozilo\|Gemfibrozilum\|Renabrazin\|Clearol\|Elmogan\|Fetinor\|Gemnpid\|Innogen\|
Specifications & Purity	Moligand™, ≥99%
Biochemical and Physiological Mechanisms	Gemfibrozil is a hyperlipidemic agent that elevates plasma HDL and lowers triglycerides and LDL by stabilizing apoA-I mRNA transcripts. It was found to inhibit inducible nitric oxide synthase by inhibiting the activation of nuclear factor-kappaB, activato
Shipped In	Normal
Grade	Moligand™
Action Type	AGONIST, INHIBITOR
Mechanism of action	Peroxisome proliferator-activated receptor alpha agonist
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Gemfibrozil (Lopid) is a compound used to lower lipid levels. A hyperlipidemic agent.

Names and Identifiers

Pubchem Sid	488179770
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488179770
IUPAC Name	5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid
INCHI	InChI=1S/C15H22O3/c1-11-6-7-12(2)13(10-11)18-9-5-8-15(3,4)14(16)17/h6-7,10H,5,8-9H2,1-4H3,(H,16,17)
InChi Key	HEMJJKBWTPKOJG-UHFFFAOYSA-N
Canonical SMILES	CC1=CC(=C(C=C1)C)OCCCC(C)(C)C(=O)O
Isomeric SMILES	CC1=CC(=C(C=C1)C)OCCCC(C)(C)C(=O)O
WGK Germany	3
RTECS	YV7120000
PubChem CID	3463
Molecular Weight	250.33
Reaxy-Rn	1881200

DrugBank Ligand

Wikipedia

CAS Registry No.

PubChem CID

ChEMBL Ligand

RCSB PDB Ligand

PEP

DrugCentral Ligand

PubChem SID

Certificates

Certificate of Analysis(COA)

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8 results found

Lot Number	Certificate Type	Date	Item
J2109437	Certificate of Analysis	Jul 07, 2023	G129727
J2109438	Certificate of Analysis	Jul 07, 2023	G129727
J2109439	Certificate of Analysis	Jul 07, 2023	G129727
G2318124	Certificate of Analysis	May 11, 2023	G129727
K1709074	Certificate of Analysis	May 11, 2023	G129727
D2314139	Certificate of Analysis	Mar 18, 2021	G129727
D2319441	Certificate of Analysis	Mar 18, 2021	G129727
F23061558	Certificate of Analysis	Mar 18, 2021	G129727

Solubility

Soluble in DMSO (50 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), ethanol (50 mg/ml at 25 °C), and chloroform.

Boil Point(°C)

159 °C/0.02 mmHg

Melt Point(°C)

61 °C

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS09, GHS07
Signal	Warning
Hazard Statements	H351:Suspected of causing cancer H411:Toxic to aquatic life with long lasting effects H302:Harmful if swallowed H361:Suspected of damaging fertility or the unborn child
Precautionary Statements	P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P391:Collect spillage. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice.
WGK Germany	3
RTECS	YV7120000
Reaxy-Rn	1881200
Merck Index	4388

References

1. Luo R et al.. (2020) Activation of PPARA-mediated autophagy reduces Alzheimer disease-like pathology and cognitive decline in a murine model.. Autophagy, 16 (52-69). [PMID:30898012]
2. Ding Y et al.. (2021) Carnitine palmitoyltransferase 1 (CPT1) alleviates oxidative stress and apoptosis of hippocampal neuron in response to beta-Amyloid peptide fragment Aß25-35.. Bioengineered, 12 (5440-5449). [PMID:34424821]

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