Genipin - 98%, high purity , CAS No.6902-77-8

  • ≥98%
Item Number
G101204
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G101204-25mg
25mg
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$9.90
G101204-100mg
100mg
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$14.90
G101204-250mg
250mg
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$19.90
G101204-500mg
500mg
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$31.90
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Cell-permeable uncoupling protein 2 inhibitor

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Basic Description

SynonymsMethyl (1S,2R,6S)-2-Hydroxy-9-(hydroxymethyl)-3-oxabicyclo[4.3.0]nona-4,8-diene-5-carboxylate | (+)-Genipin
Specifications & Purity≥98%
Biochemical and Physiological MechanismsGenipin stimulates insulin secretion in UCP2-dependent manner (Uncoupling protein 2). Genipin is a protein, collagen, gelatin, and chitosan cross-linker.Cell-permeable uncoupling protein 2 (UCP2) inhibitor. Anti-inflammatory, anti-angiogenic and pro-apoto
Storage TempStore at 2-8°C,Protected from light
Shipped InWet ice
Product Description

Genipin is a natural cross linking agent, which is extracted from gardenia fruit.It prevents lipid peroxidation and production of nitric oxide. Genipin protects the hippocampal neurons from the toxicity of Alzheimer′s amyloid β protein. It has anti-inflammatory and anti-angiogenesis effects. Genipin is involved in drug delivery system.

Associated Targets(Human)

PTPN2 Tchem T-cell protein-tyrosine phosphatase (1317 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ARSA Tbio Cerebroside-sulfatase (655 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTPN11 Tchem Protein-tyrosine phosphatase 2C (2297 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AGS (1999 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Raji (5516 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HEK293 (82097 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CD81 Tchem CD81 antigen (15 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EGR1 Tbio Early growth response protein 1 (24 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ptpn1 Protein-tyrosine phosphatase 1B (270 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Saccharomyces cerevisiae (19171 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hepatitis C virus (23859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Enterovirus A71 (1246 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RAW264.7 (28094 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Bulinus africanus (4 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

Pubchem Sid488189789
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488189789
IUPAC Name methyl (1R,4aS,7aS)-1-hydroxy-7-(hydroxymethyl)-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylate
INCHI InChI=1S/C11H14O5/c1-15-10(13)8-5-16-11(14)9-6(4-12)2-3-7(8)9/h2,5,7,9,11-12,14H,3-4H2,1H3/t7-,9-,11-/m1/s1
InChi Key AZKVWQKMDGGDSV-BCMRRPTOSA-N
Canonical SMILES COC(=O)C1=COC(C2C1CC=C2CO)O
Isomeric SMILES COC(=O)C1=CO[C@H]([C@H]2[C@@H]1CC=C2CO)O
WGK Germany 3
RTECS GY5828000
PubChem CID 442424
UN Number 2811
Molecular Weight 226.23
Reaxy-Rn 5341873

Certificates

Certificate of Analysis(COA)

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51 results found

Lot NumberCertificate TypeDateItem
J2414590Certificate of AnalysisSep 21, 2024 G101204
J2414589Certificate of AnalysisSep 21, 2024 G101204
J2414588Certificate of AnalysisSep 21, 2024 G101204
H2428151Certificate of AnalysisJul 08, 2024 G101204
H2428150Certificate of AnalysisJul 08, 2024 G101204
E2413285Certificate of AnalysisApr 26, 2024 G101204
E2413306Certificate of AnalysisApr 26, 2024 G101204
E2413338Certificate of AnalysisApr 26, 2024 G101204
A2403515Certificate of AnalysisDec 22, 2023 G101204
A2403523Certificate of AnalysisDec 22, 2023 G101204
A2403522Certificate of AnalysisDec 22, 2023 G101204
A2403521Certificate of AnalysisDec 22, 2023 G101204
A2403516Certificate of AnalysisDec 22, 2023 G101204
A2403497Certificate of AnalysisDec 22, 2023 G101204
G2301384Certificate of AnalysisJun 12, 2023 G101204
G2301387Certificate of AnalysisJun 12, 2023 G101204
G2301388Certificate of AnalysisJun 12, 2023 G101204
G2301376Certificate of AnalysisJun 12, 2023 G101204
G2301391Certificate of AnalysisJun 12, 2023 G101204
G2301392Certificate of AnalysisJun 12, 2023 G101204
G2301589Certificate of AnalysisJun 12, 2023 G101204
D2319460Certificate of AnalysisApr 08, 2023 G101204
D2319480Certificate of AnalysisApr 08, 2023 G101204
D2319477Certificate of AnalysisApr 08, 2023 G101204
D2319468Certificate of AnalysisApr 08, 2023 G101204
D2319466Certificate of AnalysisApr 08, 2023 G101204
D2319458Certificate of AnalysisApr 08, 2023 G101204
D2319456Certificate of AnalysisApr 08, 2023 G101204
D2319455Certificate of AnalysisApr 08, 2023 G101204
D2319454Certificate of AnalysisApr 08, 2023 G101204
D2319451Certificate of AnalysisApr 08, 2023 G101204
A2304671Certificate of AnalysisDec 19, 2022 G101204
A2304667Certificate of AnalysisDec 19, 2022 G101204
H2428013Certificate of AnalysisDec 19, 2022 G101204
A2304670Certificate of AnalysisDec 19, 2022 G101204
A2304672Certificate of AnalysisDec 19, 2022 G101204
A2304673Certificate of AnalysisDec 19, 2022 G101204
A2304674Certificate of AnalysisDec 19, 2022 G101204
A2304696Certificate of AnalysisDec 19, 2022 G101204
C2316780Certificate of AnalysisDec 19, 2022 G101204
H2212387Certificate of AnalysisAug 01, 2022 G101204
H2212388Certificate of AnalysisAug 01, 2022 G101204
H2212389Certificate of AnalysisAug 01, 2022 G101204
H2212409Certificate of AnalysisAug 01, 2022 G101204
H2212410Certificate of AnalysisAug 01, 2022 G101204
D1810103Certificate of AnalysisFeb 21, 2022 G101204
A2211510Certificate of AnalysisDec 18, 2021 G101204
A2211729Certificate of AnalysisDec 18, 2021 G101204
A2211696Certificate of AnalysisDec 18, 2021 G101204
A2211513Certificate of AnalysisDec 18, 2021 G101204
A2211511Certificate of AnalysisDec 18, 2021 G101204

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Chemical and Physical Properties

SolubilityDMSO: ≥25 mg/mL H2O: insoluble
SensitivityLight sensitive
Specific Rotation[α]+134 to +142 deg(C=1,MeOH)
Melt Point(°C)121 °C

Safety and Hazards(GHS)

Pictogram(s) GHS06
Signal Danger
Hazard Statements

H301:Toxic if swallowed

Precautionary Statements

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P270:Do not eat, drink or smoke when using this product.

P330:Rinse mouth.

P301+P316:IF SWALLOWED: Get emergency medical help immediately.

WGK Germany 3
RTECS GY5828000
Reaxy-Rn 5341873

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References

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Solution Calculators