Geniposide - ≥98% (HPLC), high purity , CAS No.24512-63-8

  • ≥98%(HPLC)
Item Number
G119296
Grouped product items
SKUSizeAvailabilityPrice Qty
G119296-1g
1g
In stock
$332.90
G119296-5g
5g
In stock
$1,496.90
G119296-25g
25g
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$6,733.90

Basic Description

SynonymsDTXSID101318419 | Cyclopenta(c)pyran-4-carboxylic acid, 1-(beta-D-glucopyranosyloxy)-1,4a,5,7a-tetrahydro-7-(hydroxymethyl)-, methyl ester, (1S,4aS,7aS)- | (1S)-1alpha-(beta-D-Glucopyranosyloxy)-7-(hydroxymethyl)-1,4aalpha,5,7aalpha-tetrahydrocyclopenta[c
Specifications & Purity≥98%(HPLC)
Biochemical and Physiological MechanismsGeniposide is an iridoid glycoside with a variety of biological activities including neuroprotective, anti-diabetic, antiproliferative, and antioxidative activity. Geniposide has been shown to regulate Nrf2 translocation and upregulate downstream antioxid
Storage TempStore at -20°C
Shipped InIce chest + Ice pads

Associated Targets(Human)

XDH Tclin Xanthine dehydrogenase (1038 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTPN2 Tchem T-cell protein-tyrosine phosphatase (1317 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTPN11 Tchem Protein-tyrosine phosphatase 2C (2297 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Raji (5516 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
dsDNA (365 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
quadruplex DNA (2700 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HK-2 (249 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ptpn1 Protein-tyrosine phosphatase 1B (270 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
pol Human immunodeficiency virus type 1 integrase (9041 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hepatitis C virus (23859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Enterovirus A71 (1246 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RAW264.7 (28094 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Drosophila (190 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name methyl (1S,4aS,7aS)-7-(hydroxymethyl)-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylate
INCHI InChI=1S/C17H24O10/c1-24-15(23)9-6-25-16(11-7(4-18)2-3-8(9)11)27-17-14(22)13(21)12(20)10(5-19)26-17/h2,6,8,10-14,16-22H,3-5H2,1H3/t8-,10-,11-,12-,13+,14-,16+,17+/m1/s1
InChi Key IBFYXTRXDNAPMM-BVTMAQQCSA-N
Canonical SMILES COC(=O)C1=COC(C2C1CC=C2CO)OC3C(C(C(C(O3)CO)O)O)O
Isomeric SMILES COC(=O)C1=CO[C@H]([C@H]2[C@@H]1CC=C2CO)O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O
WGK Germany 3
PubChem CID 107848
Molecular Weight 388.37

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot NumberCertificate TypeDateItem
F2411176Certificate of AnalysisJun 18, 2024 G119296
F2411177Certificate of AnalysisJun 18, 2024 G119296
F2411178Certificate of AnalysisJun 18, 2024 G119296
F2221466Certificate of AnalysisJun 24, 2022 G119296
F2221468Certificate of AnalysisJun 24, 2022 G119296

Chemical and Physical Properties

SolubilitySoluble in Ethanol
Specific Rotation[α]15° (C=1,EtOH)
Melt Point(°C)162°C

Safety and Hazards(GHS)

Pictogram(s) GHS06
Signal Danger
Hazard Statements

H301:Toxic if swallowed

Precautionary Statements

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P270:Do not eat, drink or smoke when using this product.

P330:Rinse mouth.

P301+P316:IF SWALLOWED: Get emergency medical help immediately.

WGK Germany 3

Related Documents

Citations of This Product

1. Yuxin Gan, Chenyu Wang, Chenfeng Xu, Pingping Zhang, Shutong Chen, Lei Tang, Junbing Zhang, Huahao Zhang, Shenhua Jiang.  (2023)  Simultaneous extraction of crocin and geniposide from gardenia fruits (Gardenia jasminoides Ellis) by probe-type ultrasound-assisted natural deep eutectic solvents and their inhibition effects on low density lipoprotein oxidation.  ULTRASONICS SONOCHEMISTRY,  101  (1): (106658).  [PMID:37913593] [10.1016/j.ultsonch.2023.106658]
2. Xiaoju Zhuge, Xiaosheng Jin, Tingting Ji, Rongzhou Li, Liwei Xue, Weilai Yu, Zijiao Quan, Haibin Tong, Fang Xu.  (2023)  Geniposide ameliorates dextran sulfate sodium-induced ulcerative colitis via KEAP1-Nrf2 signaling pathway.  JOURNAL OF ETHNOPHARMACOLOGY,  314  (116626).  [PMID:37187359] [10.1016/j.jep.2023.116626]
3. Ling Li, Ling Zhou, Gongshuai Song, Danli Wang, Gongnian Xiao, Fuping Zheng, Jinyan Gong.  (2023)  High efficiency biosynthesis of gardenia blue and red pigment by lactic acid bacteria: A great potential for natural color pigments.  FOOD CHEMISTRY,  417  (135868).  [PMID:36924722] [10.1016/j.foodchem.2023.135868]
4. Jiaxin Li, Hengju Ge, Yang Xu, Jiahong Xie, Fujie Yan, Wei Chen.  (2022)  Geniposide Alleviates Oxidative Damage in Hepatocytes through Regulating miR-27b-3p/Nrf2 Axis.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  70  (37): (11544–11553).  [PMID:36084288] [10.1021/acs.jafc.2c03856]
5. Sitong Lu, Zhaoyu Zhang, Youling Liang, Qingkun Zhong, Guangfa Li, Zhang Hu.  (2022)  Iridoid Glycosides from Phlomis Medicinalis Diels: Optimized Extraction and Hemostasis Evaluation.  CHEMISTRY & BIODIVERSITY,  19  (5): (e202100936).  [PMID:35502889] [10.1002/cbdv.202100936]
6. Tang Liqin, Liu Haocheng, Wen Jing, Xu Yujuan, Tian Wenni, Li Lu, Yu Yuanshan, Lin Xian, Fu Manqin.  (2021)  Study on ultrahigh-pressure extraction technology on properties of yellow extract from gardenia fruit.  JOURNAL OF FOOD COMPOSITION AND ANALYSIS,  104  (104186).  [PMID:] [10.1016/j.jfca.2021.104186]
7. Zilong Chen, Hongdong Liu, Jie Chen, Weifeng Zhu, Yong Liu, Jianxin Min, Xiaotian Chen, Bin Li, Xin Yang.  (2021)  Separation and enrichment of sibiskoside from Sibiraea angustat with magnetic surface dummy template molecularly imprinted polymers.  JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,  1178  (122767).  [PMID:34224966] [10.1016/j.jchromb.2021.122767]
8. Dong-Xing Liu, Di Zhang, Wei-Min Hu, Yan-Fang Chang, Xiao-Hui Wang, Lin Li.  (2021)  Geniposide protection against Aβ1-42 toxicity correlates with mTOR inhibition and enhancement of autophagy.  Journal of Integrative Neuroscience,  20  (1): (67-75).  [PMID:33834692] [10.31083/j.jin.2021.01.242]
9. Ma Chongyang, Wang Xueqian, Xu Tian, Zhang Shuang, Liu Shuling, Zhai Changming, Wang Zisong, Mu Jie, Li Changxiang, Cheng Fafeng, Wang Qingguo.  (2020)  An Integrative Pharmacology-Based Analysis of Refined Qingkailing Injection Against Cerebral Ischemic Stroke: A Novel Combination of Baicalin, Geniposide, Cholic Acid, and Hyodeoxycholic Acid.  Frontiers in Pharmacology,  11  (519).  [PMID:32457601] [10.3389/fphar.2020.00519]
10. Sen Yang, Ge Kuang, Rong Jiang, Shengwang Wu, Tao Zeng, Yuanyuan Wang, Fangzhi Xu, Lingyi Xiong, Xia Gong, Jingyuan Wan.  (2019)  Geniposide protected hepatocytes from acetaminophen hepatotoxicity by down-regulating CYP 2E1 expression and inhibiting TLR 4/NF-κB signaling pathway.  INTERNATIONAL IMMUNOPHARMACOLOGY,  74  (105625).  [PMID:31302451] [10.1016/j.intimp.2019.05.010]
11. Guixin Wu, Min Wen, Lin Sun, Huitao Li, Yubei Liu, Rui Li, Feihua Wu, Rong Yang, Yining Lin.  (2018)  Mechanistic insights into geniposide regulation of bile salt export pump (BSEP) expression.  RSC Advances,  (65): (37117-37128).  [PMID:35557817] [10.1039/C8RA06345A]
12. Wenhao Xu, Jingbo Yu, Wen Feng, Weike Su.  (2016)  Selective Extraction of Gardenia Yellow and Geniposide from Gardenia jasminoides by Mechanochemistry.  MOLECULES,  21  (5): (540).  [PMID:27136513] [10.3390/molecules21050540]

References

1. 甘宇鑫, 江慎华等.  (2023)  Simultaneous extraction of crocin and geniposide from gardenia fruits (Gardenia jasminoides Ellis) by probe-type ultrasound-assisted natural deep eutectic solvents and their inhibition effects on low density lipoprotein oxidation .  Ultrasonics Sonochemistry,  101  (10): (106658).  [PMID:] [https://doi.org/10.1016/j.ultsonch.2023.106658]
2. Yuxin Gan, Chenyu Wang, Chenfeng Xu, Pingping Zhang, Shutong Chen, Lei Tang, Junbing Zhang, Huahao Zhang, Shenhua Jiang.  (2023)  Simultaneous extraction of crocin and geniposide from gardenia fruits (Gardenia jasminoides Ellis) by probe-type ultrasound-assisted natural deep eutectic solvents and their inhibition effects on low density lipoprotein oxidation.  ULTRASONICS SONOCHEMISTRY,  101  (1): (106658).  [PMID:37913593] [10.1016/j.ultsonch.2023.106658]
3. Xiaoju Zhuge, Xiaosheng Jin, Tingting Ji, Rongzhou Li, Liwei Xue, Weilai Yu, Zijiao Quan, Haibin Tong, Fang Xu.  (2023)  Geniposide ameliorates dextran sulfate sodium-induced ulcerative colitis via KEAP1-Nrf2 signaling pathway.  JOURNAL OF ETHNOPHARMACOLOGY,  314  (116626).  [PMID:37187359] [10.1016/j.jep.2023.116626]
4. Ling Li, Ling Zhou, Gongshuai Song, Danli Wang, Gongnian Xiao, Fuping Zheng, Jinyan Gong.  (2023)  High efficiency biosynthesis of gardenia blue and red pigment by lactic acid bacteria: A great potential for natural color pigments.  FOOD CHEMISTRY,  417  (135868).  [PMID:36924722] [10.1016/j.foodchem.2023.135868]
5. Jiaxin Li, Hengju Ge, Yang Xu, Jiahong Xie, Fujie Yan, Wei Chen.  (2022)  Geniposide Alleviates Oxidative Damage in Hepatocytes through Regulating miR-27b-3p/Nrf2 Axis.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  70  (37): (11544–11553).  [PMID:36084288] [10.1021/acs.jafc.2c03856]
6. Sitong Lu, Zhaoyu Zhang, Youling Liang, Qingkun Zhong, Guangfa Li, Zhang Hu.  (2022)  Iridoid Glycosides from Phlomis Medicinalis Diels: Optimized Extraction and Hemostasis Evaluation.  CHEMISTRY & BIODIVERSITY,  19  (5): (e202100936).  [PMID:35502889] [10.1002/cbdv.202100936]
7. Tang Liqin, Liu Haocheng, Wen Jing, Xu Yujuan, Tian Wenni, Li Lu, Yu Yuanshan, Lin Xian, Fu Manqin.  (2021)  Study on ultrahigh-pressure extraction technology on properties of yellow extract from gardenia fruit.  JOURNAL OF FOOD COMPOSITION AND ANALYSIS,  104  (104186).  [PMID:] [10.1016/j.jfca.2021.104186]
8. Zilong Chen, Hongdong Liu, Jie Chen, Weifeng Zhu, Yong Liu, Jianxin Min, Xiaotian Chen, Bin Li, Xin Yang.  (2021)  Separation and enrichment of sibiskoside from Sibiraea angustat with magnetic surface dummy template molecularly imprinted polymers.  JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,  1178  (122767).  [PMID:34224966] [10.1016/j.jchromb.2021.122767]
9. Dong-Xing Liu, Di Zhang, Wei-Min Hu, Yan-Fang Chang, Xiao-Hui Wang, Lin Li.  (2021)  Geniposide protection against Aβ1-42 toxicity correlates with mTOR inhibition and enhancement of autophagy.  Journal of Integrative Neuroscience,  20  (1): (67-75).  [PMID:33834692] [10.31083/j.jin.2021.01.242]
10. Ma Chongyang, Wang Xueqian, Xu Tian, Zhang Shuang, Liu Shuling, Zhai Changming, Wang Zisong, Mu Jie, Li Changxiang, Cheng Fafeng, Wang Qingguo.  (2020)  An Integrative Pharmacology-Based Analysis of Refined Qingkailing Injection Against Cerebral Ischemic Stroke: A Novel Combination of Baicalin, Geniposide, Cholic Acid, and Hyodeoxycholic Acid.  Frontiers in Pharmacology,  11  (519).  [PMID:32457601] [10.3389/fphar.2020.00519]
11. Sen Yang, Ge Kuang, Rong Jiang, Shengwang Wu, Tao Zeng, Yuanyuan Wang, Fangzhi Xu, Lingyi Xiong, Xia Gong, Jingyuan Wan.  (2019)  Geniposide protected hepatocytes from acetaminophen hepatotoxicity by down-regulating CYP 2E1 expression and inhibiting TLR 4/NF-κB signaling pathway.  INTERNATIONAL IMMUNOPHARMACOLOGY,  74  (105625).  [PMID:31302451] [10.1016/j.intimp.2019.05.010]
12. Guixin Wu, Min Wen, Lin Sun, Huitao Li, Yubei Liu, Rui Li, Feihua Wu, Rong Yang, Yining Lin.  (2018)  Mechanistic insights into geniposide regulation of bile salt export pump (BSEP) expression.  RSC Advances,  (65): (37117-37128).  [PMID:35557817] [10.1039/C8RA06345A]
13. Wenhao Xu, Jingbo Yu, Wen Feng, Weike Su.  (2016)  Selective Extraction of Gardenia Yellow and Geniposide from Gardenia jasminoides by Mechanochemistry.  MOLECULES,  21  (5): (540).  [PMID:27136513] [10.3390/molecules21050540]

Solution Calculators