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G422835-1ml

1ml

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$69.90

Basic Description

Synonyms	Geniposide \| 24512-63-8 \| Jasminoidin \| UNII-145295QLXY \| CHEBI:5299 \| 145295QLXY \| 169799-41-1 \| methyl (1S,4aS,7aS)-7-(hydroxymethyl)-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylate \| Cyclopenta[c
Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	Geniposide is an iridoid glycoside with a variety of biological activities including neuroprotective, anti-diabetic, antiproliferative, and antioxidative activity. Geniposide has been shown to regulate Nrf2 translocation and upregulate downstream antioxid
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads

Associated Targets(Human)

XDH Tclin Xanthine dehydrogenase (1038 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PTPN2 Tchem T-cell protein-tyrosine phosphatase (1317 Activities)

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PTPN11 Tchem Protein-tyrosine phosphatase 2C (2297 Activities)

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Raji (5516 Activities)

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dsDNA (365 Activities)

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quadruplex DNA (2700 Activities)

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HK-2 (249 Activities)

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Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Ptpn1 Protein-tyrosine phosphatase 1B (270 Activities)

Discover Target: Ptpn1

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pol Human immunodeficiency virus type 1 integrase (9041 Activities)

Discover Target: pol

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Mus musculus (284745 Activities)

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Hepatitis C virus (23859 Activities)

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Enterovirus A71 (1246 Activities)

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RAW264.7 (28094 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

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Drosophila (190 Activities)

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SARS-CoV-2 (38078 Activities)

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Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	methyl (1S,4aS,7aS)-7-(hydroxymethyl)-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylate
INCHI	InChI=1S/C17H24O10/c1-24-15(23)9-6-25-16(11-7(4-18)2-3-8(9)11)27-17-14(22)13(21)12(20)10(5-19)26-17/h2,6,8,10-14,16-22H,3-5H2,1H3/t8-,10-,11-,12-,13+,14-,16+,17+/m1/s1
InChi Key	IBFYXTRXDNAPMM-BVTMAQQCSA-N
Canonical SMILES	COC(=O)C1=COC(C2C1CC=C2CO)OC3C(C(C(C(O3)CO)O)O)O
Isomeric SMILES	COC(=O)C1=CO[C@H]([C@H]2[C@@H]1CC=C2CO)O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O
WGK Germany	3
PubChem CID	107848
Molecular Weight	388.37

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Specific Rotation[α]	15° (C=1,EtOH)
Melt Point(°C)	162°C

Safety and Hazards(GHS)

Pictogram(s)	GHS06
Signal	Danger
Hazard Statements	H301:Toxic if swallowed
Precautionary Statements	P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P316:IF SWALLOWED: Get emergency medical help immediately.
WGK Germany	3

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Yuxin Gan, Chenyu Wang, Chenfeng Xu, Pingping Zhang, Shutong Chen, Lei Tang, Junbing Zhang, Huahao Zhang, Shenhua Jiang. (2023) Simultaneous extraction of crocin and geniposide from gardenia fruits (Gardenia jasminoides Ellis) by probe-type ultrasound-assisted natural deep eutectic solvents and their inhibition effects on low density lipoprotein oxidation. ULTRASONICS SONOCHEMISTRY, 101 (1): (106658). [PMID:37913593] [10.1016/j.ultsonch.2023.106658]
2. Xiaoju Zhuge, Xiaosheng Jin, Tingting Ji, Rongzhou Li, Liwei Xue, Weilai Yu, Zijiao Quan, Haibin Tong, Fang Xu. (2023) Geniposide ameliorates dextran sulfate sodium-induced ulcerative colitis via KEAP1-Nrf2 signaling pathway. JOURNAL OF ETHNOPHARMACOLOGY, 314 (116626). [PMID:37187359] [10.1016/j.jep.2023.116626]
3. Ling Li, Ling Zhou, Gongshuai Song, Danli Wang, Gongnian Xiao, Fuping Zheng, Jinyan Gong. (2023) High efficiency biosynthesis of gardenia blue and red pigment by lactic acid bacteria: A great potential for natural color pigments. FOOD CHEMISTRY, 417 (135868). [PMID:36924722] [10.1016/j.foodchem.2023.135868]
4. Jiaxin Li, Hengju Ge, Yang Xu, Jiahong Xie, Fujie Yan, Wei Chen. (2022) Geniposide Alleviates Oxidative Damage in Hepatocytes through Regulating miR-27b-3p/Nrf2 Axis. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 70 (37): (11544–11553). [PMID:36084288] [10.1021/acs.jafc.2c03856]
5. Sitong Lu, Zhaoyu Zhang, Youling Liang, Qingkun Zhong, Guangfa Li, Zhang Hu. (2022) Iridoid Glycosides from Phlomis Medicinalis Diels: Optimized Extraction and Hemostasis Evaluation. CHEMISTRY & BIODIVERSITY, 19 (5): (e202100936). [PMID:35502889] [10.1002/cbdv.202100936]
6. Tang Liqin, Liu Haocheng, Wen Jing, Xu Yujuan, Tian Wenni, Li Lu, Yu Yuanshan, Lin Xian, Fu Manqin. (2021) Study on ultrahigh-pressure extraction technology on properties of yellow extract from gardenia fruit. JOURNAL OF FOOD COMPOSITION AND ANALYSIS, 104 (104186). [PMID:] [10.1016/j.jfca.2021.104186]
7. Zilong Chen, Hongdong Liu, Jie Chen, Weifeng Zhu, Yong Liu, Jianxin Min, Xiaotian Chen, Bin Li, Xin Yang. (2021) Separation and enrichment of sibiskoside from Sibiraea angustat with magnetic surface dummy template molecularly imprinted polymers. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1178 (122767). [PMID:34224966] [10.1016/j.jchromb.2021.122767]
8. Dong-Xing Liu, Di Zhang, Wei-Min Hu, Yan-Fang Chang, Xiao-Hui Wang, Lin Li. (2021) Geniposide protection against Aβ1-42 toxicity correlates with mTOR inhibition and enhancement of autophagy. Journal of Integrative Neuroscience, 20 (1): (67-75). [PMID:33834692] [10.31083/j.jin.2021.01.242]
9. Ma Chongyang, Wang Xueqian, Xu Tian, Zhang Shuang, Liu Shuling, Zhai Changming, Wang Zisong, Mu Jie, Li Changxiang, Cheng Fafeng, Wang Qingguo. (2020) An Integrative Pharmacology-Based Analysis of Refined Qingkailing Injection Against Cerebral Ischemic Stroke: A Novel Combination of Baicalin, Geniposide, Cholic Acid, and Hyodeoxycholic Acid. Frontiers in Pharmacology, 11 (519). [PMID:32457601] [10.3389/fphar.2020.00519]
10. Sen Yang, Ge Kuang, Rong Jiang, Shengwang Wu, Tao Zeng, Yuanyuan Wang, Fangzhi Xu, Lingyi Xiong, Xia Gong, Jingyuan Wan. (2019) Geniposide protected hepatocytes from acetaminophen hepatotoxicity by down-regulating CYP 2E1 expression and inhibiting TLR 4/NF-κB signaling pathway. INTERNATIONAL IMMUNOPHARMACOLOGY, 74 (105625). [PMID:31302451] [10.1016/j.intimp.2019.05.010]
11. Guixin Wu, Min Wen, Lin Sun, Huitao Li, Yubei Liu, Rui Li, Feihua Wu, Rong Yang, Yining Lin. (2018) Mechanistic insights into geniposide regulation of bile salt export pump (BSEP) expression. RSC Advances, 8 (65): (37117-37128). [PMID:35557817] [10.1039/C8RA06345A]
12. Wenhao Xu, Jingbo Yu, Wen Feng, Weike Su. (2016) Selective Extraction of Gardenia Yellow and Geniposide from Gardenia jasminoides by Mechanochemistry. MOLECULES, 21 (5): (540). [PMID:27136513] [10.3390/molecules21050540]

References

1. 甘宇鑫, 江慎华等. (2023) Simultaneous extraction of crocin and geniposide from gardenia fruits (Gardenia jasminoides Ellis) by probe-type ultrasound-assisted natural deep eutectic solvents and their inhibition effects on low density lipoprotein oxidation . Ultrasonics Sonochemistry, 101 (10): (106658). [PMID:] [https://doi.org/10.1016/j.ultsonch.2023.106658]
2. Yuxin Gan, Chenyu Wang, Chenfeng Xu, Pingping Zhang, Shutong Chen, Lei Tang, Junbing Zhang, Huahao Zhang, Shenhua Jiang. (2023) Simultaneous extraction of crocin and geniposide from gardenia fruits (Gardenia jasminoides Ellis) by probe-type ultrasound-assisted natural deep eutectic solvents and their inhibition effects on low density lipoprotein oxidation. ULTRASONICS SONOCHEMISTRY, 101 (1): (106658). [PMID:37913593] [10.1016/j.ultsonch.2023.106658]
3. Xiaoju Zhuge, Xiaosheng Jin, Tingting Ji, Rongzhou Li, Liwei Xue, Weilai Yu, Zijiao Quan, Haibin Tong, Fang Xu. (2023) Geniposide ameliorates dextran sulfate sodium-induced ulcerative colitis via KEAP1-Nrf2 signaling pathway. JOURNAL OF ETHNOPHARMACOLOGY, 314 (116626). [PMID:37187359] [10.1016/j.jep.2023.116626]
4. Ling Li, Ling Zhou, Gongshuai Song, Danli Wang, Gongnian Xiao, Fuping Zheng, Jinyan Gong. (2023) High efficiency biosynthesis of gardenia blue and red pigment by lactic acid bacteria: A great potential for natural color pigments. FOOD CHEMISTRY, 417 (135868). [PMID:36924722] [10.1016/j.foodchem.2023.135868]
5. Jiaxin Li, Hengju Ge, Yang Xu, Jiahong Xie, Fujie Yan, Wei Chen. (2022) Geniposide Alleviates Oxidative Damage in Hepatocytes through Regulating miR-27b-3p/Nrf2 Axis. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 70 (37): (11544–11553). [PMID:36084288] [10.1021/acs.jafc.2c03856]
6. Sitong Lu, Zhaoyu Zhang, Youling Liang, Qingkun Zhong, Guangfa Li, Zhang Hu. (2022) Iridoid Glycosides from Phlomis Medicinalis Diels: Optimized Extraction and Hemostasis Evaluation. CHEMISTRY & BIODIVERSITY, 19 (5): (e202100936). [PMID:35502889] [10.1002/cbdv.202100936]
7. Tang Liqin, Liu Haocheng, Wen Jing, Xu Yujuan, Tian Wenni, Li Lu, Yu Yuanshan, Lin Xian, Fu Manqin. (2021) Study on ultrahigh-pressure extraction technology on properties of yellow extract from gardenia fruit. JOURNAL OF FOOD COMPOSITION AND ANALYSIS, 104 (104186). [PMID:] [10.1016/j.jfca.2021.104186]
8. Zilong Chen, Hongdong Liu, Jie Chen, Weifeng Zhu, Yong Liu, Jianxin Min, Xiaotian Chen, Bin Li, Xin Yang. (2021) Separation and enrichment of sibiskoside from Sibiraea angustat with magnetic surface dummy template molecularly imprinted polymers. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1178 (122767). [PMID:34224966] [10.1016/j.jchromb.2021.122767]
9. Dong-Xing Liu, Di Zhang, Wei-Min Hu, Yan-Fang Chang, Xiao-Hui Wang, Lin Li. (2021) Geniposide protection against Aβ1-42 toxicity correlates with mTOR inhibition and enhancement of autophagy. Journal of Integrative Neuroscience, 20 (1): (67-75). [PMID:33834692] [10.31083/j.jin.2021.01.242]
10. Ma Chongyang, Wang Xueqian, Xu Tian, Zhang Shuang, Liu Shuling, Zhai Changming, Wang Zisong, Mu Jie, Li Changxiang, Cheng Fafeng, Wang Qingguo. (2020) An Integrative Pharmacology-Based Analysis of Refined Qingkailing Injection Against Cerebral Ischemic Stroke: A Novel Combination of Baicalin, Geniposide, Cholic Acid, and Hyodeoxycholic Acid. Frontiers in Pharmacology, 11 (519). [PMID:32457601] [10.3389/fphar.2020.00519]
11. Sen Yang, Ge Kuang, Rong Jiang, Shengwang Wu, Tao Zeng, Yuanyuan Wang, Fangzhi Xu, Lingyi Xiong, Xia Gong, Jingyuan Wan. (2019) Geniposide protected hepatocytes from acetaminophen hepatotoxicity by down-regulating CYP 2E1 expression and inhibiting TLR 4/NF-κB signaling pathway. INTERNATIONAL IMMUNOPHARMACOLOGY, 74 (105625). [PMID:31302451] [10.1016/j.intimp.2019.05.010]
12. Guixin Wu, Min Wen, Lin Sun, Huitao Li, Yubei Liu, Rui Li, Feihua Wu, Rong Yang, Yining Lin. (2018) Mechanistic insights into geniposide regulation of bile salt export pump (BSEP) expression. RSC Advances, 8 (65): (37117-37128). [PMID:35557817] [10.1039/C8RA06345A]
13. Wenhao Xu, Jingbo Yu, Wen Feng, Weike Su. (2016) Selective Extraction of Gardenia Yellow and Geniposide from Gardenia jasminoides by Mechanochemistry. MOLECULES, 21 (5): (540). [PMID:27136513] [10.3390/molecules21050540]

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Geniposide - 10mM in DMSO, high purity , CAS No.24512-63-8

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Citations of This Product

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator