Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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G106672-20mg | 20mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $31.90 | |
G106672-1g | 1g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $686.90 | |
G106672-5g | 5g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $2,403.90 |
Synonyms | genistein | 446-72-0 | Prunetol | 4',5,7-Trihydroxyisoflavone | Genisterin | Genisteol | Sophoricol | 5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one | 5,7,4'-Trihydroxyisoflavone | Bonistein | Genestein | Differenol A | NPI 031L | 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopy |
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Specifications & Purity | Moligand™, analytical standard, ≥98% |
Biochemical and Physiological Mechanisms | Description: |
Storage Temp | Protected from light,Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | analytical standard, Moligand™ |
Action Type | ACTIVATOR, AGONIST |
Mechanism of action | Activator of CFTR;Agonist of Estrogen receptor-β;Agonist of Estrogen-related receptor-α;Agonist of Estrogen-related receptor-β;Agonist of Estrogen-related receptor-γ;Agonist of TAS2R14;Agonist of TAS2R39;Activator of TRPC5 |
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IUPAC Name | 5,7-dihydroxy-3-(4-hydroxyphenyl)chromen-4-one |
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INCHI | InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)11-7-20-13-6-10(17)5-12(18)14(13)15(11)19/h1-7,16-18H |
InChi Key | TZBJGXHYKVUXJN-UHFFFAOYSA-N |
Canonical SMILES | C1=CC(=CC=C1C2=COC3=CC(=CC(=C3C2=O)O)O)O |
Isomeric SMILES | C1=CC(=CC=C1C2=COC3=CC(=CC(=C3C2=O)O)O)O |
WGK Germany | 3 |
RTECS | NR2392000 |
PubChem CID | 5280961 |
Molecular Weight | 270.24 |
Beilstein | 263823 |
Reaxy-Rn | 263823 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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K1820022 | Certificate of Analysis | Apr 03, 2024 | G106672 |
K2327044 | Certificate of Analysis | Nov 30, 2023 | G106672 |
C2125019 | Certificate of Analysis | Dec 15, 2022 | G106672 |
C2226643 | Certificate of Analysis | May 24, 2022 | G106672 |
C2226617 | Certificate of Analysis | May 23, 2022 | G106672 |
Sensitivity | Heat sensitive;Light sensitive |
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Melt Point(°C) | 297-298°C |
Pictogram(s) | GHS09, GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed H400:Very toxic to aquatic life H410:Very toxic to aquatic life with long lasting effects |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P391:Collect spillage. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
RTECS | NR2392000 |
Reaxy-Rn | 263823 |
Merck Index | 4391 |
Starting at $64.90
Starting at $46.90
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31. Peng Hua, Donglin Yang, Ruie Chen, Peiqi Qiu, Meiwan Chen. (2022) ROS responsive polyethylenimine-based fluorinated polymers for enhanced transfection efficiency and lower cytotoxicity. Bosnian Journal of Basic Medical Sciences, 22 (4): ( 593–607). [PMID:35531984] |
32. Yejun Zhong, Lei Yang, Taotao Dai, Ziyi Zhu, Hongyu Chen, Jianyong Wu, Er Sheng Gong. (2022) Flavonoids enhance gel strength of ovalbumin: Properties, structures, and interactions. FOOD CHEMISTRY, 387 (132892). [PMID:35405558] |
33. Yejun Zhong, Lei Yang, Ziyi Zhu, Hongyu Chen, Chengmei Liu, Taotao Dai, Er Sheng Gong. (2022) Protective effect of ovalbumin-flavonoid hydrogel on thrombolytic activity and stability of nattokinase. FOOD RESEARCH INTERNATIONAL, 156 (111188). [PMID:35651046] |
34. Jie Zhao, Lin Huang, Renjie Li, Zhuangwei Zhang, Jin Chen, Hongjin Tang. (2022) Insights from multi-spectroscopic analysis and molecular modeling to understand the structure–affinity relationship and the interaction mechanism of flavonoids with gliadin. Food & Function, 13 (9): (5061-5074). [PMID:35404372] |
35. Lei Du, Kum-Song Ro, Yiji Zhang, Ya-Jie Tang, Wanbang Li, Jingli Xie, Dongzhi Wei. (2022) Effects of lactiplantibacillus plantarum X7021 on physicochemical properties, purines, isoflavones and volatile compounds of fermented soymilk. PROCESS BIOCHEMISTRY, 113 (150). [PMID:] |
36. Liuming Xie, Zhibing Huang, Hui Meng, Zhibing Fan, Xiaoyi Shi, Jianhua Xie. (2022) Role of genistein on the yield, structure and immunomodulatory activity of Monascus exopolysaccharides. Food & Function, 13 (3): (1393-1407). [PMID:35045151] |
37. Zhuxian Wang, Yaqi Xue, Quanfu Zeng, Zhaoming Zhu, Yuan Wang, Yufan Wu, Chunyan Shen, Hongxia Zhu, Cuiping Jiang, Li Liu, Qiang Liu. (2022) Glycyrrhiza acid-Licochalcone A complexes for enhanced bioavailability and anti-melanogenic effect of Licochalcone A: cellular uptake and in vitro experiments. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 68 (103037). [PMID:] |
38. Suleixin Yang, Ka Hong Wong, Peng Hua, Chengwei He, Hua Yu, Dan Shao, Zhi Shi, Meiwan Chen. (2022) ROS-responsive fluorinated polyethyleneimine vector to co-deliver shMTHFD2 and shGPX4 plasmids induces ferroptosis and apoptosis for cancer therapy. Acta Biomaterialia, 140 (492). [PMID:34879292] |
39. Wenjie Feng, Wanrui Shi, Shuwei Liu, Huiwen Liu, Yi Liu, Pengfei Ge, Hao Zhang. (2021) Fe(III)-Shikonin Supramolecular Nanomedicine for Combined Therapy of Tumor via Ferroptosis and Necroptosis. Advanced Healthcare Materials, 11 (2): (2101926). [PMID:34738742] |
40. Cuiping Jiang, Yuan Wang, Peiyi Liang, Yao Chen, Ziming Zhuang, Lu Zhang, Yankui Yi, Li Liu, Qiang Liu. (2021) ATP-Responsive Multifunctional Supramolecular Polymer as a Nonviral Vector for Boosting Cholesterol Removal from Lipid-Laden Macrophages. ACS Biomaterials Science & Engineering, 7 (11): (5048–5063). [PMID:34648280] |
41. Chi H, Gu Y, Xu T, Cao F. (2017) Multifunctional organic-inorganic hybrid nanoparticles and nanosheets based on chitosan derivative and layered double hydroxide: cellular uptake mechanism and application for topical ocular drug delivery.. Int J Nanomedicine, 12 (3): (1607-1620). [PMID:28280329] |
42. Xu T, Xu X, Gu Y, Fang L, Cao F. (2018) Functional intercalated nanocomposites with chitosan-glutathione-glycylsarcosine and layered double hydroxides for topical ocular drug delivery.. Int J Nanomedicine, 13 (3): (917-937). [PMID:29491707] |
43. Wang Y, Zhou L, Fang L, Cao F. (2020) Multifunctional carboxymethyl chitosan derivatives-layered double hydroxide hybrid nanocomposites for efficient drug delivery to the posterior segment of the eye.. Acta Biomater, 104 (3): (104-114). [PMID:31931169] |
1. Yulin Mo, Yanjun Yang, Jingqi Zeng, Weikun Ma, Yuxin Guan, Jingxi Guo, Xiaochun Wu, Dingkun Liu, Liang Feng, Xiaobin Jia, Bing Yang. (2023) Enhancing the Biopharmacological Characteristics of Asperosaponin VI: Unveiling Dynamic Self-Assembly Phase Transitions in the Gastrointestinal Environment. International Journal of Nanomedicine, [PMID:38084126] |
2. Yue Hu, Qing Nie, Xianling Cong, Wen Wu, Qiong Wu, Qihui Liu, Yuanyuan Li, Haiyan Liu, Jingyan Ge, Fangfang Chen. (2024) PEN-coated superparamagnetic iron-mediated delivery of siSnail2 to inhibit metastasis and promote ferroptosis in the treatment of cancer. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 650 (123728). [PMID:38142015] |
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6. Yufeng Chen, Guobin Xia, Chunfeng Wang, Huawei Wu, Xiaogang Xu, Genxiang Mao, Jiong Wu, Zhenlei Zhao. (2023) Impact of dietary plant flavonoids on 7,8-dihydroxyflavone transepithelial transport in human intestinal Caco-2 cells. Food Science & Nutrition, [PMID:37970375] |
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9. Haiyun Yang, Zhiqing Peng, Liuming Xie, Jianhua Xie, Zhibing Huang. (2023) Adding genistein or luteolin decreased the yield of citrinin and without reducing pigments in yam solid-fermentation by Monascus. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 103 (13): (6440-6451). [PMID:37209398] |
10. Mengsi Zhang, Lu Wang, Hao Jin, Nan Zhao, Yi Liu, Shijie Lan, Shuwei Liu, Hao Zhang. (2023) Employing single valency polyphenol to prepare metal-phenolic network antitumor reagents through FeOOH assistance. JOURNAL OF CONTROLLED RELEASE, 358 (612). [PMID:37196899] |
11. Shengnan Huang, Chengzhi Song, Jinxin Miao, Xiali Zhu, Yongyan Jia, Yafei Liu, Dongjun Fu, Benyi Li, Mingsan Miao, Shaofeng Duan, Zhenzhong Zhang, Yurong Hu. (2023) Red blood cell membrane-coated functionalized Au nanocage as a biomimetic platform for improved MicroRNA delivery in hepatocellular carcinoma. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 642 (123044). [PMID:37178790] |
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16. Shi-Jie Hao, Ya-Xuan Zhu, Fu-Gen Wu. (2023) Membrane fusion-mediated delivery of small-molecule HER2 tyrosine kinase inhibitor for effective tumor chemosensitization. JOURNAL OF CONTROLLED RELEASE, 357 (222). [PMID:36958404] |
17. Yanzhi Xing, Yulong Xu, Yanna Lin, E Shuang, Han Leng, Jianhua Wang, Xuwei Chen. (2023) Rational synthesis of carbon dots with phosphate ester group for direct mapping of endogenous alkaline phosphatase and polarity monitoring in living cells. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 640 (626). [PMID:36889060] |
18. Yuan Gao, Yingxi Zhang, Hong Xia, Yuqing Ren, Haibin Zhang, Siwen Huang, Meiju Li, Yongjun Wang, Heran Li, Hongzhuo Liu. (2023) Biomimetic virus-like mesoporous silica nanoparticles improved cellular internalization for co-delivery of antigen and agonist to enhance Tumor immunotherapy. DRUG DELIVERY, 30 (1): (2183814). [PMID:36843529] |
19. Fangping Liang, Wurong Li, Mingao Li, Xican Li, Jianfeng He, Quanzhou Wu. (2023) Kaempferol molecularly imprinted polymers: preparation, characterization and application to the separation of kaempferol from ginkgo leaves. POLYMER INTERNATIONAL, 72 (6): (586-596). [PMID:] |
20. Han Haobo, Xing Jiakai, Chen Wenqi, Jia Jiaxin, Li Quanshun. (2023) Fluorinated polyamidoamine dendrimer-mediated miR-23b delivery for the treatment of experimental rheumatoid arthritis in rats. Nature Communications, 14 (1): (1-20). [PMID:36805456] |
21. Wen-Juan Shen, Duo-Mei Tian, Le Fu, Biao Jin, Yu Liu, Yun-Sheng Xu, Yong-Bin Ye, Xiao-Bo Wang, Xiao-Jun Xu, Chun Tang, Fang-Ping Li, Chun-Fei Wang, Gang Wu, Le-Ping Yan. (2023) Elastin-Derived VGVAPG Fragment Decorated Cell-Penetrating Peptide with Improved Gene Delivery Efficacy. Pharmaceutics, 15 (2): (670). [PMID:36839992] |
22. Nini Xin, Dong Gao, Borui Su, Ting Zhou, Yuda Zhu, Chengheng Wu, Dan Wei, Jing Sun, Hongsong Fan. (2023) Orange-Emissive Carbon Dots with High Photostability for Mitochondrial Dynamics Tracking in Living Cells. ACS Sensors, 8 (3): (1161–1172). [PMID:36795996] |
23. Mang-Mang Li, Yi-Ting Chen, Jin-Cang Ruan, Wen-Jun Wang, Ji-Guang Chen, Qing-Feng Zhang. (2023) Structure-activity relationship of dietary flavonoids on pancreatic lipase. Current Research in Food Science, 6 (100424). [PMID:36618100] |
24. Yue Huang, Xiaojing Si, Mei Han, Chen Bai. (2022) Rapid and Sensitive Detection of Rutin in Food Based on Nitrogen-Doped Carbon Quantum Dots as Fluorescent Probe. MOLECULES, 27 (24): (8834). [PMID:36557970] |
25. Zhong Wenzhao, Guo Feng, Chen Fangman, Law Man-Kay, Lu Jun, Shao Dan, Yu Hua, Chan Ging, Chen Meiwan. (2022) A multifunctional oxidative stress nanoamplifier with ROS amplification and GSH exhaustion for enhanced chemodynamic therapy. Frontiers in Pharmacology, 13 [PMID:36438812] |
26. Guo Yuxin, Wang Shao-Zhe, Zhang Xinping, Jia Hao-Ran, Zhu Ya-Xuan, Zhang Xiaodong, Gao Ge, Jiang Yao-Wen, Li Chengcheng, Chen Xiaokai, Wu Shun-Yu, Liu Yi, Wu Fu-Gen. (2022) In situ generation of micrometer-sized tumor cell-derived vesicles as autologous cancer vaccines for boosting systemic immune responses. Nature Communications, 13 (1): (1-20). [PMID:36319625] |
27. Jie Yang, Xiuhua Pan, Jun Zhang, Siyu Ma, Jianeng Zhou, Zengguang Jia, Yawen Wei, Zengyi Liu, Ning Yang, Qi Shen. (2022) Reprogramming dysfunctional dendritic cells by a versatile metabolism nano-intervenor for enhancing cancer combinatorial immunotherapy. Nano Today, 46 (101618). [PMID:] |
28. Li-Min Zhai, Yan Zhao, Rui-Lin Xiao, Shi-Quan Zhang, Bao-Hua Tian, Xin-Xin Li, Rong Zhang, Ri-Sheng Ma, Hai-Xia Liang. (2022) Nuclear-targeted carbon quantum dot mediated CRISPR/Cas9 delivery for fluorescence visualization and efficient editing. Nanoscale, 14 (39): (14645-14660). [PMID:36165075] |
29. Ren Chuanhong, Guo Yan, Xie Linfeng, Zhao Zhikang, Xing Mengyun, Cao Yunlin, Liu Yilong, Lin Jing, Grierson Donald, Zhang Bo, Xu Changjie, Chen Kunsong, Li Xian. (2022) Identification of UDP-rhamnosyltransferases and UDP-galactosyltransferase involved in flavonol glycosylation in Morella rubra. Horticulture Research, 9 [PMID:36072838] |
30. Yanyan Wang, Hai Gao, Xinya Huang, Zhaoan Chen, Pengyu Kang, Yunyi Zhou, Danhua Qin, Wenli Zhang, Jianping Liu. (2022) Cyclodextrin boostered-high density lipoprotein for antiatherosclerosis by regulating cholesterol efflux and efferocytosis. CARBOHYDRATE POLYMERS, 292 (119632). [PMID:35725197] |
31. Peng Hua, Donglin Yang, Ruie Chen, Peiqi Qiu, Meiwan Chen. (2022) ROS responsive polyethylenimine-based fluorinated polymers for enhanced transfection efficiency and lower cytotoxicity. Bosnian Journal of Basic Medical Sciences, 22 (4): ( 593–607). [PMID:35531984] |
32. Yejun Zhong, Lei Yang, Taotao Dai, Ziyi Zhu, Hongyu Chen, Jianyong Wu, Er Sheng Gong. (2022) Flavonoids enhance gel strength of ovalbumin: Properties, structures, and interactions. FOOD CHEMISTRY, 387 (132892). [PMID:35405558] |
33. Yejun Zhong, Lei Yang, Ziyi Zhu, Hongyu Chen, Chengmei Liu, Taotao Dai, Er Sheng Gong. (2022) Protective effect of ovalbumin-flavonoid hydrogel on thrombolytic activity and stability of nattokinase. FOOD RESEARCH INTERNATIONAL, 156 (111188). [PMID:35651046] |
34. Jie Zhao, Lin Huang, Renjie Li, Zhuangwei Zhang, Jin Chen, Hongjin Tang. (2022) Insights from multi-spectroscopic analysis and molecular modeling to understand the structure–affinity relationship and the interaction mechanism of flavonoids with gliadin. Food & Function, 13 (9): (5061-5074). [PMID:35404372] |
35. Lei Du, Kum-Song Ro, Yiji Zhang, Ya-Jie Tang, Wanbang Li, Jingli Xie, Dongzhi Wei. (2022) Effects of lactiplantibacillus plantarum X7021 on physicochemical properties, purines, isoflavones and volatile compounds of fermented soymilk. PROCESS BIOCHEMISTRY, 113 (150). [PMID:] |
36. Liuming Xie, Zhibing Huang, Hui Meng, Zhibing Fan, Xiaoyi Shi, Jianhua Xie. (2022) Role of genistein on the yield, structure and immunomodulatory activity of Monascus exopolysaccharides. Food & Function, 13 (3): (1393-1407). [PMID:35045151] |
37. Zhuxian Wang, Yaqi Xue, Quanfu Zeng, Zhaoming Zhu, Yuan Wang, Yufan Wu, Chunyan Shen, Hongxia Zhu, Cuiping Jiang, Li Liu, Qiang Liu. (2022) Glycyrrhiza acid-Licochalcone A complexes for enhanced bioavailability and anti-melanogenic effect of Licochalcone A: cellular uptake and in vitro experiments. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 68 (103037). [PMID:] |
38. Suleixin Yang, Ka Hong Wong, Peng Hua, Chengwei He, Hua Yu, Dan Shao, Zhi Shi, Meiwan Chen. (2022) ROS-responsive fluorinated polyethyleneimine vector to co-deliver shMTHFD2 and shGPX4 plasmids induces ferroptosis and apoptosis for cancer therapy. Acta Biomaterialia, 140 (492). [PMID:34879292] |
39. Wenjie Feng, Wanrui Shi, Shuwei Liu, Huiwen Liu, Yi Liu, Pengfei Ge, Hao Zhang. (2021) Fe(III)-Shikonin Supramolecular Nanomedicine for Combined Therapy of Tumor via Ferroptosis and Necroptosis. Advanced Healthcare Materials, 11 (2): (2101926). [PMID:34738742] |
40. Cuiping Jiang, Yuan Wang, Peiyi Liang, Yao Chen, Ziming Zhuang, Lu Zhang, Yankui Yi, Li Liu, Qiang Liu. (2021) ATP-Responsive Multifunctional Supramolecular Polymer as a Nonviral Vector for Boosting Cholesterol Removal from Lipid-Laden Macrophages. ACS Biomaterials Science & Engineering, 7 (11): (5048–5063). [PMID:34648280] |
41. Chi H, Gu Y, Xu T, Cao F. (2017) Multifunctional organic-inorganic hybrid nanoparticles and nanosheets based on chitosan derivative and layered double hydroxide: cellular uptake mechanism and application for topical ocular drug delivery.. Int J Nanomedicine, 12 (3): (1607-1620). [PMID:28280329] |
42. Xu T, Xu X, Gu Y, Fang L, Cao F. (2018) Functional intercalated nanocomposites with chitosan-glutathione-glycylsarcosine and layered double hydroxides for topical ocular drug delivery.. Int J Nanomedicine, 13 (3): (917-937). [PMID:29491707] |
43. Wang Y, Zhou L, Fang L, Cao F. (2020) Multifunctional carboxymethyl chitosan derivatives-layered double hydroxide hybrid nanocomposites for efficient drug delivery to the posterior segment of the eye.. Acta Biomater, 104 (3): (104-114). [PMID:31931169] |