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Genistin - analytical standard,≥98%, high purity , CAS No.529-59-9

17 Citations
Item Number
G113837
Grouped product items
SKUSizeAvailabilityPrice Qty
G113837-20mg
20mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$69.90
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Basic Description

SynonymsCHEBI:27514 | AKOS025146960 | MFCD00016883 | NSC 5112 | AS-11684 | G0358 | Genistin, analytical standard | Genistein 7-O-b-D-glucopyranoside | Genistein glucoside | 5,4'-DI-HYDROXYISOFLAVONE-7-O-.BETA.-D-GLUCOPYRANOSIDE | 5-hydroxy-3-(4-hydroxyphenyl)-4-o
Specifications & Purityanalytical standard, ≥98%
Biochemical and Physiological MechanismsInactive analog of genistein; useful as a negative control for genistein and other tyrosine kinase inhibitors.
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
Gradeanalytical standard
Product Description

Genistin is an isoflavone glycoside found in soy-based food products. This is an inactive analog of the PTK inhibitor Genistein and can be used as a negative control for Genistein. Reported to reduce bone loss in ovarectomized rats. Genistin is an inhibitor of TdT.
An isoflavone glycoside which is an inactive analog of the PTK inhibitor Genistein.

Associated Targets(Human)

EGFR Tclin Epidermal growth factor receptor erbB1 (33727 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
XDH Tclin Xanthine dehydrogenase (1038 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ishikawa (877 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
dsDNA (365 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
quadruplex DNA (2700 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Staphylococcus aureus (210822 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Escherichia coli (133304 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cryptococcus neoformans (21258 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Candida albicans (78123 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
LLC-PK1 (2135 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RAW264.7 (28094 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BCHE Cholinesterase (8742 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Spodoptera litura (1708 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 5-hydroxy-3-(4-hydroxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one
INCHI InChI=1S/C21H20O10/c22-7-15-18(26)19(27)20(28)21(31-15)30-11-5-13(24)16-14(6-11)29-8-12(17(16)25)9-1-3-10(23)4-2-9/h1-6,8,15,18-24,26-28H,7H2/t15-,18-,19+,20-,21-/m1/s1
InChi Key ZCOLJUOHXJRHDI-CMWLGVBASA-N
Canonical SMILES C1=CC(=CC=C1C2=COC3=CC(=CC(=C3C2=O)O)OC4C(C(C(C(O4)CO)O)O)O)O
Isomeric SMILES C1=CC(=CC=C1C2=COC3=CC(=CC(=C3C2=O)O)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)O
WGK Germany 3
RTECS DJ3093000
PubChem CID 5281377
Molecular Weight 432.38
Beilstein 64479

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot NumberCertificate TypeDateItem
G2305776Certificate of AnalysisJan 13, 2023 G113837
F1827120Certificate of AnalysisFeb 22, 2022 G113837

Chemical and Physical Properties

SolubilitySoluble in water (partly ), DMSO (10 mg/ml), pyridine (19.60-20.40 mg/ml), and dilute aqueous base.
Melt Point(°C)265°C

Safety and Hazards(GHS)

WGK Germany 3
RTECS DJ3093000
Merck Index 4391

Related Documents

 SDS

 Specification Sheet

Citations of This Product

How to Cite Aladdin Scientific Products?
1. Wenjie Yu, Fengjie Sun, Ruixin Xu, Meng Cui, Yongquan Liu, Quanyuan Xie, Limin Guo, Chenxian Kong, Xin Li, Xiali Guo, Liping Luo.  (2023)  Chemical composition and anti-inflammatory activities of Castanopsis honey.  Food & Function,  14  (1): (250-261).  [PMID:36484340] [10.1039/D2FO02233H]
2. Jie Zhao, Lin Huang, Renjie Li, Zhuangwei Zhang, Jin Chen, Hongjin Tang.  (2022)  Insights from multi-spectroscopic analysis and molecular modeling to understand the structure–affinity relationship and the interaction mechanism of flavonoids with gliadin.  Food & Function,  13  (9): (5061-5074).  [PMID:35404372] [10.1039/D1FO03816H]
3. Lei Du, Kum-Song Ro, Yiji Zhang, Ya-Jie Tang, Wanbang Li, Jingli Xie, Dongzhi Wei.  (2022)  Effects of lactiplantibacillus plantarum X7021 on physicochemical properties, purines, isoflavones and volatile compounds of fermented soymilk.  PROCESS BIOCHEMISTRY,  113  (150).  [PMID:] [10.1016/j.procbio.2021.12.028]
4. Wang Huawei, Shan Xiajing, Ren Mengtian, Shang Mengdi, Zhou Chuanzheng.  (2021)  Nucleosomes enter cells by clathrin- and caveolin-dependent endocytosis.  NUCLEIC ACIDS RESEARCH,  49  (21): (12306-12319).  [PMID:34865123] [10.1093/nar/gkab1121]
5. Liuying Zhu, Wenting Li, Zeyuan Deng, Hongyan Li, Bing Zhang.  (2020)  The Composition and Antioxidant Activity of Bound Phenolics in Three Legumes, and Their Metabolism and Bioaccessibility of Gastrointestinal Tract.  Foods,  9  (12): (1816).  [PMID:33297502] [10.3390/foods9121816]
6. Xiaoyi Qu, Bo Ding, Jing Li, Meng Liang, Liqin Du, Yutuo Wei, Ribo Huang, Hao Pang.  (2020)  Characterization of a GH3 halophilic β-glucosidase from Pseudoalteromonas and its NaCl-induced activity toward isoflavones.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  164  (1392).  [PMID:32763400] [10.1016/j.ijbiomac.2020.07.300]
7. Yu-ting Li, Ming-shun Chen, Li-zhen Deng, Ya-zhen Liang, Yi-kun Liu, Wei Liu, Jun Chen, Cheng-mei Liu.  (2021)  Whole soybean milk produced by a novel industry-scale micofluidizer system without soaking and filtering.  JOURNAL OF FOOD ENGINEERING,  291  (110228).  [PMID:] [10.1016/j.jfoodeng.2020.110228]
8. Hongjin Tang, Lin Huang, Dongsheng Zhao, Chunyong Sun, Ping Song.  (2020)  Interaction mechanism of flavonoids on bovine serum albumin: Insights from molecular property-binding affinity relationship.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  239  (118519).  [PMID:32480277] [10.1016/j.saa.2020.118519]
9. Jie Zhao, Lin Huang, Chunyong Sun, Dongsheng Zhao, Hongjin Tang.  (2020)  Studies on the structure-activity relationship and interaction mechanism of flavonoids and xanthine oxidase through enzyme kinetics, spectroscopy methods and molecular simulations.  FOOD CHEMISTRY,  323  (126807).  [PMID:32330646] [10.1016/j.foodchem.2020.126807]
10. Xianli Gao, Ermeng Liu, Junke Zhang, Mingquan Yang, Sui Chen, Zhan Liu, Haile Ma, Feng Hu.  (2019)  Effects of sonication during moromi fermentation on antioxidant activities of compounds in raw soy sauce.  LWT-FOOD SCIENCE AND TECHNOLOGY,  116  (108605).  [PMID:] [10.1016/j.lwt.2019.108605]
11. Xiaonan Zhang, Hongwei Zhang, Xinghao Xia, Nan Pu, Zhuping Yu, Mourtada Nabih, Ying Zhu, Shuang Zhang, Lianzhou Jiang.  (2019)  Preparation and physicochemical characterization of soy isoflavone (SIF) nanoparticles by a liquid antisolvent precipitation method.  ADVANCED POWDER TECHNOLOGY,  30  (1522).  [PMID:] [10.1016/j.apt.2019.04.030]
12. Xingyu Hou, Wei Huang, Fugui Zhu, Fang Geng, Miaomiao Tian.  (2019)  A new boronate-affinity hollow solid phase extraction adsorbent for the enrichment of cis-diol-containing isoflavones in soybean milk samples.  Analytical Methods,  11  (3): (317-326).  [PMID:] [10.1039/C8AY02311E]
13. Hu Yue, Xia Qinfei, Huang Wei, Hou Xingyu, Tian Miaomiao.  (2018)  Boronate-modified hollow molecularly imprinted polymers for selective enrichment of glycosides.  MICROCHIMICA ACTA,  185  (1): (1-9).  [PMID:29594569] [10.1007/s00604-017-2608-2]
14. Han Peng, Wenting Li, Hongyan Li, Zeyuan Deng, Bing Zhang.  (2017)  Extractable and non-extractable bound phenolic compositions and their antioxidant properties in seed coat and cotyledon of black soybean (Glycinemax (L.) merr).  Journal of Functional Foods,  32  (296).  [PMID:] [10.1016/j.jff.2017.03.003]
15. Yonggang Feng, Qin Liu, Lifang Ye, Quanzhou Wu, Jianfeng He.  (2017)  Ordered macroporous quercetin molecularly imprinted polymers: Preparation, characterization, and separation performance.  JOURNAL OF SEPARATION SCIENCE,  40  (4): (971-978).  [PMID:28012243] [10.1002/jssc.201601011]
16. Shuzhen Yang, Jie Zhou, Dongmei Li, Chunyu Shang, Litao Peng, Siyi Pan.  (2017)  The structure-antifungal activity relationship of 5,7-dihydroxyflavonoids against Penicillium italicum.  FOOD CHEMISTRY,  224  (26).  [PMID:28159264] [10.1016/j.foodchem.2016.12.001]
17. Hui Cao,Xiaojuan Liu,Nataša Poklar Ulrih,Pradeep K Sengupta,Jianbo Xiao.  (2018-09-04)  Plasma protein binding of dietary polyphenols to human serum albumin: A high performance affinity chromatography approach..  Food chemistry,  270  (257-263).  [PMID:30174044]

References

1. Wenjie Yu, Fengjie Sun, Ruixin Xu, Meng Cui, Yongquan Liu, Quanyuan Xie, Limin Guo, Chenxian Kong, Xin Li, Xiali Guo, Liping Luo.  (2023)  Chemical composition and anti-inflammatory activities of Castanopsis honey.  Food & Function,  14  (1): (250-261).  [PMID:36484340] [10.1039/D2FO02233H]
2. Jie Zhao, Lin Huang, Renjie Li, Zhuangwei Zhang, Jin Chen, Hongjin Tang.  (2022)  Insights from multi-spectroscopic analysis and molecular modeling to understand the structure–affinity relationship and the interaction mechanism of flavonoids with gliadin.  Food & Function,  13  (9): (5061-5074).  [PMID:35404372] [10.1039/D1FO03816H]
3. Lei Du, Kum-Song Ro, Yiji Zhang, Ya-Jie Tang, Wanbang Li, Jingli Xie, Dongzhi Wei.  (2022)  Effects of lactiplantibacillus plantarum X7021 on physicochemical properties, purines, isoflavones and volatile compounds of fermented soymilk.  PROCESS BIOCHEMISTRY,  113  (150).  [PMID:] [10.1016/j.procbio.2021.12.028]
4. Wang Huawei, Shan Xiajing, Ren Mengtian, Shang Mengdi, Zhou Chuanzheng.  (2021)  Nucleosomes enter cells by clathrin- and caveolin-dependent endocytosis.  NUCLEIC ACIDS RESEARCH,  49  (21): (12306-12319).  [PMID:34865123] [10.1093/nar/gkab1121]
5. Liuying Zhu, Wenting Li, Zeyuan Deng, Hongyan Li, Bing Zhang.  (2020)  The Composition and Antioxidant Activity of Bound Phenolics in Three Legumes, and Their Metabolism and Bioaccessibility of Gastrointestinal Tract.  Foods,  9  (12): (1816).  [PMID:33297502] [10.3390/foods9121816]
6. Xiaoyi Qu, Bo Ding, Jing Li, Meng Liang, Liqin Du, Yutuo Wei, Ribo Huang, Hao Pang.  (2020)  Characterization of a GH3 halophilic β-glucosidase from Pseudoalteromonas and its NaCl-induced activity toward isoflavones.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  164  (1392).  [PMID:32763400] [10.1016/j.ijbiomac.2020.07.300]
7. Yu-ting Li, Ming-shun Chen, Li-zhen Deng, Ya-zhen Liang, Yi-kun Liu, Wei Liu, Jun Chen, Cheng-mei Liu.  (2021)  Whole soybean milk produced by a novel industry-scale micofluidizer system without soaking and filtering.  JOURNAL OF FOOD ENGINEERING,  291  (110228).  [PMID:] [10.1016/j.jfoodeng.2020.110228]
8. Hongjin Tang, Lin Huang, Dongsheng Zhao, Chunyong Sun, Ping Song.  (2020)  Interaction mechanism of flavonoids on bovine serum albumin: Insights from molecular property-binding affinity relationship.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  239  (118519).  [PMID:32480277] [10.1016/j.saa.2020.118519]
9. Jie Zhao, Lin Huang, Chunyong Sun, Dongsheng Zhao, Hongjin Tang.  (2020)  Studies on the structure-activity relationship and interaction mechanism of flavonoids and xanthine oxidase through enzyme kinetics, spectroscopy methods and molecular simulations.  FOOD CHEMISTRY,  323  (126807).  [PMID:32330646] [10.1016/j.foodchem.2020.126807]
10. Xianli Gao, Ermeng Liu, Junke Zhang, Mingquan Yang, Sui Chen, Zhan Liu, Haile Ma, Feng Hu.  (2019)  Effects of sonication during moromi fermentation on antioxidant activities of compounds in raw soy sauce.  LWT-FOOD SCIENCE AND TECHNOLOGY,  116  (108605).  [PMID:] [10.1016/j.lwt.2019.108605]
11. Xiaonan Zhang, Hongwei Zhang, Xinghao Xia, Nan Pu, Zhuping Yu, Mourtada Nabih, Ying Zhu, Shuang Zhang, Lianzhou Jiang.  (2019)  Preparation and physicochemical characterization of soy isoflavone (SIF) nanoparticles by a liquid antisolvent precipitation method.  ADVANCED POWDER TECHNOLOGY,  30  (1522).  [PMID:] [10.1016/j.apt.2019.04.030]
12. Xingyu Hou, Wei Huang, Fugui Zhu, Fang Geng, Miaomiao Tian.  (2019)  A new boronate-affinity hollow solid phase extraction adsorbent for the enrichment of cis-diol-containing isoflavones in soybean milk samples.  Analytical Methods,  11  (3): (317-326).  [PMID:] [10.1039/C8AY02311E]
13. Hu Yue, Xia Qinfei, Huang Wei, Hou Xingyu, Tian Miaomiao.  (2018)  Boronate-modified hollow molecularly imprinted polymers for selective enrichment of glycosides.  MICROCHIMICA ACTA,  185  (1): (1-9).  [PMID:29594569] [10.1007/s00604-017-2608-2]
14. Han Peng, Wenting Li, Hongyan Li, Zeyuan Deng, Bing Zhang.  (2017)  Extractable and non-extractable bound phenolic compositions and their antioxidant properties in seed coat and cotyledon of black soybean (Glycinemax (L.) merr).  Journal of Functional Foods,  32  (296).  [PMID:] [10.1016/j.jff.2017.03.003]
15. Yonggang Feng, Qin Liu, Lifang Ye, Quanzhou Wu, Jianfeng He.  (2017)  Ordered macroporous quercetin molecularly imprinted polymers: Preparation, characterization, and separation performance.  JOURNAL OF SEPARATION SCIENCE,  40  (4): (971-978).  [PMID:28012243] [10.1002/jssc.201601011]
16. Shuzhen Yang, Jie Zhou, Dongmei Li, Chunyu Shang, Litao Peng, Siyi Pan.  (2017)  The structure-antifungal activity relationship of 5,7-dihydroxyflavonoids against Penicillium italicum.  FOOD CHEMISTRY,  224  (26).  [PMID:28159264] [10.1016/j.foodchem.2016.12.001]
17. Hui Cao,Xiaojuan Liu,Nataša Poklar Ulrih,Pradeep K Sengupta,Jianbo Xiao.  (2018-09-04)  Plasma protein binding of dietary polyphenols to human serum albumin: A high performance affinity chromatography approach..  Food chemistry,  270  (257-263).  [PMID:30174044]

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