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Gepotidacin - 98%, high purity , Bacterial DNA gyrase inhibitor, CAS No.1075236-89-3, Bacterial DNA gyrase inhibitor

Moligand™
≥98%

CAS#: 1075236-89-3
Formula: C₂₄H₂₈N₆O₃
Molecular Weight: 448.52
PubChem CID: 25101874

Item Number

G610547

Grouped product items
SKU	Size	Availability	Price
G610547-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$109.90
G610547-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$359.90
G610547-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$699.90
G610547-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,399.90

View related series

Bacterial-Topoisomerase

Basic Description

Synonyms	Gepotidacin\|1075236-89-3\|GSK2140944\|GSK-2140944\|GSK 2140944\|DVF0PR037D\|3H,8H-2a,5,8a-Triazaacenaphthylene-3,8-dione, 2-((4-(((3,4-dihydro-2H-pyrano(2,3-C)pyridin-6-yl)methyl)amino)-1-piperidinyl)methyl)-1,2-dihydro-, (2R)-\|(2R)-2-[(4-{[(3,4-dihydro-2H-pyr
Specifications & Purity	Moligand™, ≥98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Bacterial DNA gyrase inhibitor
Product Description	Gepotidacin is a novel triazaacenaphthylene bacterial type II topoisomerase inhibitor.

Associated Targets

TOP2A Tclin DNA topoisomerase 2-alpha 0 Activities

Discover Target: TOP2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities

Discover Target: KCNH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(3R)-3-[[4-(3,4-dihydro-2H-pyrano[2,3-c]pyridin-6-ylmethylamino)piperidin-1-yl]methyl]-1,4,7-triazatricyclo[6.3.1.04,12]dodeca-6,8(12),9-triene-5,11-dione
INCHI	InChI=1S/C24H28N6O3/c31-22-4-3-20-24-29(22)15-19(30(24)23(32)13-27-20)14-28-7-5-17(6-8-28)25-11-18-10-16-2-1-9-33-21(16)12-26-18/h3-4,10,12-13,17,19,25H,1-2,5-9,11,14-15H2/t19-/m1/s1
InChi Key	PZFAZQUREQIODZ-LJQANCHMSA-N
Canonical SMILES	O=c1cnc2c3n1[C@H](CN1CCC(CC1)NCc1ncc4c(c1)CCCO4)Cn3c(=O)cc2
Isomeric SMILES	C1CC2=CC(=NC=C2OC1)CNC3CCN(CC3)C[C@@H]4CN5C(=O)C=CC6=C5N4C(=O)C=N6
PubChem CID	25101874
Molecular Weight	448.52

CAS Registry No.

PubChem CID

ChEMBL Ligand

BindingDB Ligand

DrugBank Ligand

RCSB PDB Ligand

Antibiotic DB

Certificates

Certificate of Analysis(COA)

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7 results found

Lot Number	Certificate Type	Date	Item
G2415204	Certificate of Analysis	Apr 01, 2024	G610547
G2415205	Certificate of Analysis	Apr 01, 2024	G610547
G2415206	Certificate of Analysis	Apr 01, 2024	G610547
G2415207	Certificate of Analysis	Apr 01, 2024	G610547
G2415208	Certificate of Analysis	Apr 01, 2024	G610547
G2415209	Certificate of Analysis	Apr 01, 2024	G610547
G2415210	Certificate of Analysis	Apr 01, 2024	G610547

References

1. Farrell DJ, Sader HS, Rhomberg PR, Scangarella-Oman NE, Flamm RK. (2017) In Vitro Activity of Gepotidacin (GSK2140944) against Neisseria gonorrhoeae.. Antimicrob Agents Chemother, 61 (3): (589-97). [PMID:28069643]
2. Biedenbach DJ, Bouchillon SK, Hackel M, Miller LA, Scangarella-Oman NE, Jakielaszek C, Sahm DF. (2016) In Vitro Activity of Gepotidacin, a Novel Triazaacenaphthylene Bacterial Topoisomerase Inhibitor, against a Broad Spectrum of Bacterial Pathogens.. Antimicrob Agents Chemother, 60 (3): (1918-23). [PMID:26729499]
3. O'Riordan W, Tiffany C, Scangarella-Oman N, Perry C, Hossain M, Ashton T, Dumont E. (2017) Efficacy, Safety, and Tolerability of Gepotidacin (GSK2140944) in the Treatment of Patients with Suspected or Confirmed Gram-Positive Acute Bacterial Skin and Skin Structure Infections.. Antimicrob Agents Chemother, 61 (6): (589-97). [PMID:28373199]
4. Hackel MA, Karlowsky JA, Canino MA, Sahm DF, Scangarella-Oman NE. (2022) In Vitro Activity of Gepotidacin against Gram-Negative and Gram-Positive Anaerobes.. Antimicrob Agents Chemother, 66 (2): (e0216521). [PMID:34930028]
5. Jacobsson S, Golparian D, Scangarella-Oman N, Unemo M. (2018) In vitro activity of the novel triazaacenaphthylene gepotidacin (GSK2140944) against MDR Neisseria gonorrhoeae.. J Antimicrob Chemother, 73 (8): (2072-2077). [PMID:29796611]
6. Gibson EG, Bax B, Chan PF, Osheroff N. (2019) Mechanistic and Structural Basis for the Actions of the Antibacterial Gepotidacin against Staphylococcus aureus Gyrase.. ACS Infect Dis, 5 (4): (570-581). [PMID:30757898]

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