GGTI-286 - Trifluoroacetate salt, high purity , CAS No.171744-11-9

Item Number

G335348

Grouped product items
SKU	Size	Availability	Price	Qty
G335348-250μg	250μg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$198.90

a potent, selective, cell-permeable inhibitor of GGTase I

Basic Description

Specifications & Purity	Trifluoroacetate salt
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	GGTI-286 is a potent, cell-permeable, and selective inhibitor of GGTase I. This methyl ester derivative of GGTI-287 is about 25-fold more potent than FTI-277 in inhibiting the processing of the geranylgeranylated protein Rap1A. GGTI-286 has also been shown to have a significant antiproliferative effect in human malignant glioma cells. It also selectively antagonizes oncogenic K-Ras4B.

Associated Targets(Human)

FNTA Tclin Protein farnesyltransferase (3470 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

FNTA Tclin Geranylgeranyl transferase type I (851 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	methyl (2S)-2-[[4-[[(2R)-2-amino-3-sulfanylpropyl]amino]-2-phenylbenzoyl]amino]-4-methylpentanoate
INCHI	InChI=1S/C23H31N3O3S/c1-15(2)11-21(23(28)29-3)26-22(27)19-10-9-18(25-13-17(24)14-30)12-20(19)16-7-5-4-6-8-16/h4-10,12,15,17,21,25,30H,11,13-14,24H2,1-3H3,(H,26,27)/t17-,21+/m1/s1
InChi Key	IENQPUVVSDIXCT-UTKZUKDTSA-N
Canonical SMILES	CC(C)CC(C(=O)OC)NC(=O)C1=C(C=C(C=C1)NCC(CS)N)C2=CC=CC=C2
Isomeric SMILES	CC(C)C[C@@H](C(=O)OC)NC(=O)C1=C(C=C(C=C1)NC[C@H](CS)N)C2=CC=CC=C2
PubChem CID	3012117
Molecular Weight	429.57

Pictogram(s)

Signal

Warning

Hazard Statements

H400:Very toxic to aquatic life

H410:Very toxic to aquatic life with long lasting effects

Precautionary Statements

P273:Avoid release to the environment.

P501:Dispose of contents/container to ...

P391:Collect spillage.

Solution Calculators

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Basic Description