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GGTI 298 - 10mM in DMSO, high purity , CAS No.1217457-86-7

Item Number

G420939

Grouped product items
SKU	Size	Availability	Price	Qty
G420939-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$667.90

Geranylgeranyltransferase I (GGTase I) inhibitor

Basic Description

Synonyms	1217457-86-7 \| GGTI298 Trifluoroacetate \| Ggti 298 \| GGTI 298 trifluoroacetate salt hydrate \| GGTI 298 TFA salt \| GGTI-298 TFA \| GGTI298 (Trifluoroacetate) \| 1217457-86-7 (TFA) \| methyl (2S)-2-[[4-[[(2R)-2-amino-3-sulfanylpropyl]amino]-2-naphthalen-1-ylbenzoyl]amino]-4-m
Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor. Strongly inhibits the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras (IC50values are 3 and > 10μM respectively). Causes G0-G1cell cycle b
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads

HepG2 (196354 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

IUPAC Name	methyl (2S)-2-[[4-[[(2R)-2-amino-3-sulfanylpropyl]amino]-2-naphthalen-1-ylbenzoyl]amino]-4-methylpentanoate;2,2,2-trifluoroacetic acid
INCHI	InChI=1S/C27H33N3O3S.C2HF3O2/c1-17(2)13-25(27(32)33-3)30-26(31)23-12-11-20(29-15-19(28)16-34)14-24(23)22-10-6-8-18-7-4-5-9-21(18)22;3-2(4,5)1(6)7/h4-12,14,17,19,25,29,34H,13,15-16,28H2,1-3H3,(H,30,31);(H,6,7)/t19-,25+;/m1./s1
InChi Key	WALKWJPZELDSKT-UFABNHQSSA-N
Canonical SMILES	CC(C)CC(C(=O)OC)NC(=O)C1=C(C=C(C=C1)NCC(CS)N)C2=CC=CC3=CC=CC=C32.C(=O)(C(F)(F)F)O
Isomeric SMILES	CC(C)C[C@@H](C(=O)OC)NC(=O)C1=C(C=C(C=C1)NC[C@H](CS)N)C2=CC=CC3=CC=CC=C32.C(=O)(C(F)(F)F)O
PubChem CID	16078971
Molecular Weight	593.66

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