GGTI-298 TFA - ≥95%(HPLC), high purity , CAS No.1217457-86-7

Item Number

G287072

Grouped product items
SKU	Size	Availability	Price
G287072-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$97.90
G287072-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$195.90
G287072-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$303.90
G287072-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$597.90
G287072-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$815.90

Geranylgeranyltransferase I (GGTase I) inhibitor

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Basic Description

Synonyms	GGTI298 (Trifluoroacetate) \| DTXSID70582025 \| PLVGDGRBPMVYPB-FDUHJNRSSA-N \| BG178516 \| GGTI 298 TFA salt \| Ggti 298 \| N-[4-[2(R)-Amino-3-mercaptopropyl]amino-2-(1-naphthalenyl)benzoyl]-L-leucine methyl ester trifluoroacetate salt \| GGTI 298 trifluoroaceta
Specifications & Purity	≥95%(HPLC)
Biochemical and Physiological Mechanisms	CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor. Strongly inhibits the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras (IC50values are 3 and > 10μM respectively). Causes G0-G1cell cycle b
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads

Names and Identifiers

IUPAC Name	methyl (2S)-2-[[4-[[(2R)-2-amino-3-sulfanylpropyl]amino]-2-naphthalen-1-ylbenzoyl]amino]-4-methylpentanoate;2,2,2-trifluoroacetic acid
INCHI	InChI=1S/C27H33N3O3S.C2HF3O2/c1-17(2)13-25(27(32)33-3)30-26(31)23-12-11-20(29-15-19(28)16-34)14-24(23)22-10-6-8-18-7-4-5-9-21(18)22;3-2(4,5)1(6)7/h4-12,14,17,19,25,29,34H,13,15-16,28H2,1-3H3,(H,30,31);(H,6,7)/t19-,25+;/m1./s1
InChi Key	WALKWJPZELDSKT-UFABNHQSSA-N
Canonical SMILES	CC(C)CC(C(=O)OC)NC(=O)C1=C(C=C(C=C1)NCC(CS)N)C2=CC=CC3=CC=CC=C32.C(=O)(C(F)(F)F)O
Isomeric SMILES	CC(C)C[C@@H](C(=O)OC)NC(=O)C1=C(C=C(C=C1)NC[C@H](CS)N)C2=CC=CC3=CC=CC=C32.C(=O)(C(F)(F)F)O
PubChem CID	16078971
Molecular Weight	593.66

Solubility

Solvent:DMSO, Max Conc. mg/mL: 14.84, Max Conc. mM: 25

Sensitivity

Moisture sensitive

Solution Calculators

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Basic Description