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GI254023X - 98% (HPLC), high purity , CAS No.260264-93-5, Inhibitor of ADAM10;Inhibitor of ADAM17
Selective ADAM10 metalloprotease inhibitor
Basic Description Synonyms GI4023 | AKOS025401993 | J-016226 | SCHEMBL11989235 | CCG-268545 | GI 254023X | (2r)-n-[(1s)-2,2-dimethyl-1-[(methylamino)carbonyl]-propyl]-2-[(1s)-1-[formyl(hydroxy)amino]ethyl]-5-phenylpentanamide | AC-27562 | Benzenepentanamide, N-[(1S)-2,2-dimethyl-1- Specifications & Purity Moligand™, ≥98%(HPLC) Biochemical and Physiological Mechanisms Selective ADAM10 metalloprotease inhibitor; displays over 100-fold higher potency at ADAM10 compared to ADAM17. Blocks constitutive release of IL-6R, CX3CL1 and CXCL16 in cell-based cleavage experiments. Inhibits calcium ionophore-induced betacellulin she Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type INHIBITOR Mechanism of action Inhibitor of ADAM10;Inhibitor of ADAM17 Product Description Product Application：
GI254023X has been used to inhibit ADAM10 (ADAM metallopeptidase domain 10).
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name (2R)-N-[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]-2-[(1S)-1-[formyl(hydroxy)amino]ethyl]-5-phenylpentanamide INCHI InChI=1S/C21H33N3O4/c1-15(24(28)14-25)17(13-9-12-16-10-7-6-8-11-16)19(26)23-18(20(27)22-5)21(2,3)4/h6-8,10-11,14-15,17-18,28H,9,12-13H2,1-5H3,(H,22,27)(H,23,26)/t15-,17+,18+/m0/s1 InChi Key GHVMTHKJUAOZJP-CGTJXYLNSA-N Canonical SMILES CC(C(CCCC1=CC=CC=C1)C(=O)NC(C(=O)NC)C(C)(C)C)N(C=O)O Isomeric SMILES C[C@@H]([C@@H](CCCC1=CC=CC=C1)C(=O)N[C@H](C(=O)NC)C(C)(C)C)N(C=O)O WGK Germany 3 PubChem CID 9952396 Molecular Weight 391.5
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 7.83, Max Conc. mM: 20
References 1. Ludwig A, Hundhausen C, Lambert MH, Broadway N, Andrews RC, Bickett DM, Leesnitzer MA, Becherer JD. (2005) Metalloproteinase inhibitors for the disintegrin-like metalloproteinases ADAM10 and ADAM17 that differentially block constitutive and phorbol ester-inducible shedding of cell surface molecules.. Comb Chem High Throughput Screen, 8 (2): (161-71). [PMID:15777180 ] [10.1021/op500134e ]
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A2211792