Gimeracil - ≥98%, high purity , Dihydropyrimidine dehydrogenase inhibitor, CAS No.103766-25-2, Dihydropyrimidine dehydrogenase inhibitor

Item Number

G129778

Grouped product items
SKU	Size	Availability	Price
G129778-250mg	250mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$23.90
G129778-1g	1g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$71.90
G129778-5g	5g	In stock	$235.90
G129778-25g	25g	In stock	$1,060.90
G129778-100g	100g	In stock	$3,816.90

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Basic Description

Synonyms	Gimeracil\|103766-25-2\|gimestat\|5-Chloro-2,4-dihydroxypyridine\|5-chloropyridine-2,4-diol\|5-Chloro-4-hydroxy-2(1H)-pyridone\|5-Chloro-4-hydroxy-2(1H)-pyridinone\|Gimeracil [INN]\|5-Chloro-4-hydroxy-1H-pyridin-2-one\|5-Chloro-2,4-pyridinediol\|5-CHLORO-4-HYDROXYP
Specifications & Purity	≥98%
Storage Temp	Store at -20°C
Shipped In	Dry ice
Action Type	INHIBITOR
Mechanism of action	Dihydropyrimidine dehydrogenase inhibitor
Product Description	Gimeracil is an inhibitor of dihydropyrimidine dehydrogenase, which inhibits the early step in homologous recombination for double strand breaks repair. A potent inhibitor of dihydropyrimidine dehydrogenase (DPD).

Names and Identifiers

IUPAC Name	5-chloro-4-hydroxy-1H-pyridin-2-one
INCHI	InChI=1S/C5H4ClNO2/c6-3-2-7-5(9)1-4(3)8/h1-2H,(H2,7,8,9)
InChi Key	ZPLQIPFOCGIIHV-UHFFFAOYSA-N
Canonical SMILES	C1=C(C(=CNC1=O)Cl)O
Isomeric SMILES	C1=C(C(=CNC1=O)Cl)O
PubChem CID	54679224
Molecular Weight	145.54
Beilstein	21(4)2059
Reaxy-Rn	119489

Certificates

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5 results found

Lot Number	Certificate Type	Date	Item
B1528016	Certificate of Analysis	Jun 12, 2024	G129778
K2123054	Certificate of Analysis	Sep 19, 2023	G129778
K2123199	Certificate of Analysis	Sep 19, 2023	G129778
K2123200	Certificate of Analysis	Sep 19, 2023	G129778
J1912206	Certificate of Analysis	May 10, 2023	G129778

Solubility

Soluble in DMSO (29 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C).

Melt Point(°C)

274°C(dec.)(lit.)

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
Reaxy-Rn	119489

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Basic Description